Thomas Jefferson University Hospital

A novel perioperative pathway for hip fractures in the older adult: a pre-post quality improvement study using statistical process control

Despite advances in medical care, the incidence of medical complications, especially delirium, remains high in patients with hip fracture. Although individual components of hip fracture pathways have been studied, the components together have not. At a tertiary academic medical c...

Using Hospital Mortality Data to Inform Creation of an Acute Care Inpatient GIP Hospice Program Led by an Academic Palliative Care Team

Background: Acute Care General Inpatient (GIP) Hospice within hospital systems is becoming more common nationally. Palliative care teams are often involved in programmatic planning. Methods: A retrospective chart review of 100 inpatient acute care deaths was conducted to review c...

Efficacy and safety of intraoperative red blood cell salvage transfusion for spinal deformity surgery: a systematic review and meta-analysis

Spinal deformity surgery is associated with substantial blood loss and high transfusion requirements, exposing patients to the risks of allogeneic blood transfusion. Intraoperative cell salvage (ICS) is widely used in patient blood management strategies, yet its clinical efficacy...

Timing Matters: Preoperative Lumbar Epidural Steroid Injection and Long-Term Outcomes Following Single-Level Posterior Lumbar Fusion

Study Design Retrospective Cohort Analysis. Objective CESIs are a mainstay of nonoperative treatment for degenerative lumbar spine disease. As increasing numbers of patients undergo sPLF after receiving CESIs, understanding their impact on surgical outcomes is essential. The obje...

Association of food insecurity with gastrointestinal and hepatic conditions in U.S. adults: A population-based study

Background Food insecurity affects 2.33 billion people worldwide and disproportionately impacts those with inflammatory bowel disease (IBD). However, population-level evidence linking food insecurity and gastrointestinal (GI) conditions remains limited. Aim To examine the associa...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Management of non-survivable head trauma: Opportunities for improvement

Background Managing patients with non-survivable head trauma who do not meet brain death criteria presents significant ethical and clinical challenges. Decisions frequently fall to surrogates with limited guidance, particularly when organ donation status is unknown. This study as...

Operative vs non-operative management of ventral hernia: a population based study of long-term benefits and consequences

Abstract Purpose Ventral hernia (VH) management has progressed beyond simply physical repair of the defect. It now involves a strategy that purposefully restores abdominal core function and prevents future complications. This study investigates the association between ventral her...

Medetomidine as a Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, and Management

Abstract Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in...

A Surgical Algorithm for Upper Cervical Trauma Based on the AO Spine Upper Cervical Injury Classification System

Study Design. Global cross-sectional survey Objective. To establish a surgical algorithm for upper cervical spine injuries using the AO Spine Upper Cervical Injury Classification (UCIC) system, defining operative thresholds using a novel proposed Upper Cervical AO-Spine Injury Sc...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Long-Term Recovery Trajectories After Endovascular Treatment of Carotid-Cavernous Fistulas: A Single-Center Cohort Study

BACKGROUND AND OBJECTIVES: Carotid-cavernous fistulas (CCFs) are uncommon arteriovenous shunts that can present with a wide range of nonspecific ophthalmic and neurological symptoms, often leading to diagnostic delays. While endovascular embolization is the primary treatment moda...

Endoscopic versus catheter-based minimally invasive evacuation of spontaneous supratentorial intracerebral hemorrhage: a systematic review and meta-analysis

Abstract Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage ± thrombolysis), but comparative performance remains uncertain. We performed a systematic...

Cavernous Sinus Thrombosis: Presentation, Management, and Initial Diagnostic Uncertainty

ABSTRACT Objective Cavernous sinus thrombosis (CST) is a life‐threatening diagnosis. Early CST may be difficult to detect, presenting without overt orbital findings or classic radiographic clues. The objective is to present the largest single‐institution series characterizing pre...

A Randomized Hybrid Type I Effectiveness-Implementation Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2): study protocol

Abstract Background Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. There are also targeted treatments for some genetic carriers with cancers such as breast and ov...