Thermo Fisher Scientific (United States)

A validated amplicon panel for parentage reconstruction and selection monitoring in whitefish (Coregonus spp.)

Abstract Fish populations are notoriously difficult to monitor because their aquatic habitats limit observation. While physical or chemical tagging (e.g., adipose fin removal or Alizarin Red S staining of bones) can reduce growth or survival or requires sacrifice, genetic tools o...

Machine Learning-Assisted Key Toxicant Identification from Mass Spectra: A Case Study of AhR Agonists in Polypropylene Face Masks

Abstract Identifying key toxicants that drive biological effects in complex samples remains a major challenge for environmental analytical chemistry. Here, we developed an AhR-oriented machine-learning model, EIMSFrag-AhR, to predict AhR agonistic activity directly from GC-EI-MS...

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K + channel TASK-2

TWIK-related acid-sensitive K+ channel 2 (TASK-2) is a pH sensing two-pore K + (K2P) channel that regulates respiration in brainstem neurons and systemic pH homeostasis in kidney. Despite its physiological importance and implication in disease, the molecular basis for intracellul...

Implementation of Nano Flow Chromatography Coupled to Mass Spectrometry as a Reliable and Sensitive Discovery Lipidomics Platform

RATIONALE: Untargeted lipidomics is commonly performed at analytical flow rates, which consume more solvent and may require higher on-column sample loads when sensitivity is limited by analyte abundance. Nano flow separations use lower flow rates and sample loads, reducing solven...

A Paint Library of Plastic Particles (PLoPP): a spectral library, visual key, and machine learning model for paint microplastic identification

The degradation of paint is thought to be a major pathway of microplastics to the environment. However, pollution from paint microplastics is challenging to assess due to a lack of paint-specific spectral libraries and visual keys to aid in the differentiation of paint microplast...

Harmonizing M-protein analysis: an international, multi-center reproducibility study of mass spectrometry and evaluation of concordance to electrophoretic methods

Abstract Objectives Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are commonly performed by SPE or CZE and IFE or IT, respectively. While these assays are widely used, they are characterized by limited sensitivity and...

Modeling the public health impact of vaccination with Pfizer-BioNTech COVID-19 vaccine, LP.8.1, 2025–2026 formula in the pediatric population aged 5–17 years at high risk of severe outcomes from COVID-19 in the United States

INTRODUCTION: This study evaluated the potential public health impact of receiving Pfizer-BioNTech COVID-19 vaccine, LP.8.1, 2025-2026 formula, in the US pediatric population aged 5-17 years at high risk of severe outcomes from COVID-19. RESEARCH DESIGN AND METHODS: A previously...