The University of Western Australia

Predicting recovery outcomes following mild traumatic brain injury in an Australian community cohort: Results from the Concussion Recovery Study (CREST)

Background Most people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-mo...

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

The Framework for Policy Decision on the RTS,S/AS01 malaria vaccine: the use of emerging data to inform global policy on the first malaria vaccine

The World Health Organization (WHO)-coordinated Malaria Vaccine Implementation Programme (MVIP) supported pilot introductions of the RTS,S/AS01 malaria vaccine by the ministries of health through the childhood immunization programmes in Ghana, Kenya and Malawi from 2019 through 2...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

A call for action with the burden of cirrhosis in Australia

Unlike most other chronic diseases and cancers in Australia, outcomes for cirrhosis and hepatocellular cancer are not improving. Public hospitals are overwhelmed by decompensated cirrhosis and struggling to provide best practice care for the large population of patients with less...

Is it (socially) contagious? Capturing spatial-temporal trends of pro-environmental gardening using hazard models

Planting native gardens on verges, a form of underutilised public land, can provide biodiversity-enhancing and water-saving benefits that help achieve urban environmental goals. As a result, many governments in Australia offer support programs to encourage the adoption of native...

Reversible Inhibition of Ammonia Monooxygenase by 1,9-Decanediol Triggers a RegB-RegA-Associated Energy Crisis and Stress Response in Nitrosomonas europaea

Abstract 1,9-decanediol, a rice-derived biological nitrification inhibitor (BNI) suppresses soil nitrification and nitrous-oxide emissions, but the mechanisms of action against ammonia-oxidizing bacteria remain unclear. Combining physiology and transcriptomics in Nitrosomonas eur...

On the edge: habitat patchiness and island isolation fracture the distribution of the endemic Kimberley rock-rat

We integrate demography, morphology and genetics to assess the biology and population structure of the endemic Kimberley rock-rat (Zyzomys woodwardi), a habitat specialist of the monsoonal tropics. The species is confined to the extreme north-west of the continent and 16 adjacent...

Are X-Ray Atmospheres Heated by Turbulent Dissipation? XRISM Constraints

Abstract We evaluate whether dissipation of turbulence injected into hot cluster atmospheres by jets and bubbles can offset radiative cooling flows. No trends are found between atmospheric velocity dispersion, σ v , and either the ratio of kinetic to thermal energy or jet power o...

Acute Reactive Strength Responses and Peak Power–Performance Relationships After Flywheel Calf Raises in National‐Level Track‐and‐Field Athletes: A Randomized Crossover Trial

ABSTRACT This study examined reactive strength responses to flywheel eccentric calf raises performed under three inertial loads and the associations between peak power and post‐intervention reactive strength. Thirty‐seven national‐level male track‐and‐field athletes completed thr...

A Word of Caution: Watch and Wait in the Total Mesorectal Excision Era

ABSTRACT Background Watch and wait strategies offer organ preservation for selected patients with rectal cancer following neoadjuvant chemoradiotherapy ( nCRT ). Long‐term outcomes following nCRT and total mesorectal excision ( TME ) provide important context for evaluating these...

Simulating Infrared Spectra of Matrix Isolation Experiments: What Works Best?

ABSTRACT Matrix isolation is an experimental technique which allows spectroscopists to observe highly reactive or weakly bound systems by trapping them in frozen noble gas matrices. In this work, we studied the viability of using ab initio molecular dynamics (AIMD) to simulate se...

A method for characterising fire events in high fire frequency landscapes: case study application to North Kimberley fire regimes, Western Australia

Background Identifying fire events provides insights into fire size distribution, the timing of significant fire events, their behaviour and ignition causes. However, this can be challenging when using temporally coarse datasets across high-fire-frequency savanna landscapes. Aims...

Gravity topography modeling of the Denman Glacier region using a geostatistical approach

The Denman Glacier is one of East Antarctica's most dynamic outlet systems and is modeled to host the deepest continental marine trough, with the potential to contribute up to ∼ 1.5 m of global sea level rise. Yet its bed geometry remains poorly constrained because airborne radar...

Not all cover is equal: a multi-material comparison of artificial cover boards for small vertebrate surveys in subtropical Queensland, Australia

Abstract Artificial cover boards (ACBs) are increasingly used globally for surveying small vertebrates. Comparative studies assessing multiple ACB types simultaneously; however, are uncommon, especially in subtropical regions. This study evaluated detection probabilities for rept...

Detection of viral pathogens associated with acute lower respiratory infection in children in the Eastern Highlands Province of Papua New Guinea: a matched case-control study

Introduction In Papua New Guinea, acute lower respiratory infection (ALRI) is the most common reason for childhood hospitalisation and death. Recent changes in epidemiology, diagnostic approaches and vaccine policy warrant re-examination of the aetiology of ALRI. Methods A matche...

How cultural norms affect attitudes toward immigration

We examine how cultural norms shape attitudes toward immigration. Using representative survey data on German university students from the 1990s, we exploit the stark cultural differences between former East and West Germany to study whether moving to a different cultural environm...

Social welfare implications of policy reform for dog shelters in the United Kingdom

Statistics suggest that the policies currently in place to manage free-roaming dog numbers in the United Kingdom have met with limited success, and more innovative alternatives should be considered. This paper explores potential policy reform options that could reduce welfare los...

Corticosteroid use in children with community acquired sepsis: a multicentre prospective cohort study

Objectives Corticosteroids in paediatric sepsis have the potential to improve outcomes, yet there is little supporting evidence regarding efficacy, choice of agents, dose or timing of administration. We describe the patterns of corticosteroid use in children hospitalised with sus...

Research on Carbon Emissions Based on Full Lifecycle and BIM Technology for Buildings

This paper focuses on quantifying overall lifecycle carbon emissions of a case-study structure, identifying key emission stages, and proposing carbon reduction strategies. The lifecycle assessment (LCA) framework combined with BIM technology was used to calculate stage-wise carbo...