The University of Western Australia

Microclimatic effects on activity patterns in a montane chimpanzee population

Abstract Climatic variation can shape primate activity budgets by altering the energetic and thermoregulatory costs of feeding, resting, locomotion and social behaviour. However, little is known about how chimpanzees that inhabit cool, wet montane forests adjust their activity in...

Impact of Socioeconomic Status and Rurality on the Rate of Prenatal Detection of Major and Critical Congenital Heart Disease in Western Australia

AIM: Prenatal diagnosis of congenital heart disease (CHD) is associated with reduced infant morbidity and mortality. Location and subsequent socioeconomic status influence rates and timing of prenatal diagnoses of CHD. We investigated the impact of socioeconomic status and rurali...

Management and outcomes of renal colic in pregnancy: A 10-year Australian tertiary centre experience

Objective: To describe the presentation, management and maternal-foetal outcomes of pregnant patients with symptomatic upper tract obstruction. Patients and methods: A retrospective cohort study was performed of pregnant patients managed for renal colic or symptomatic hydronephro...

A Carboxymethyl Cellulose Hydrogel Switch Enabling pH-Responsive Fertilizer

Abstract The Green Revolution boosted crop yields with synthetic fertilizers, but their high solubility causes environmental pollution and poor synchronization with crop nutrient demands. To address this problem, we developed green intelligent fertilizers (GIF) using a pH-respons...

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

ABSTRACT Postmenopausal osteoporosis is caused by excessive osteoclast‐mediated bone resorption. This study identifies mitochondrial oxidative phosphorylation (OXPHOS) as a tractable metabolic target for antiresorptive therapy. A literature‐guided drug repurposing screen focused...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

A staged clinical development and evidence-generation framework for Group A Streptococcus vaccines

Group A Streptococcus (Strep A) causes substantial global morbidity and mortality, yet vaccine development faces scientific, regulatory, and strategic challenges. We propose a platform-agnostic, staged clinical development and evidence-generation framework aligning trial feasibil...

Helical Anchor Pullout Using a Semifluidized Bounding Surface Plasticity Model

Abstract The ultimate vertical pullout capacity of single-helix anchors in sand was explored using the coupled Eulerian–Lagrangian (CEL) technique to account for large deformation processes. A semifluidized bounding surface plasticity model was incorporated in a novel manner to i...

To Acquire or to Ally? Foreign Competition and Firm Boundary

ABSTRACT This study examines how foreign competition influences firms’ external growth strategies. Exploiting staggered US import tariff reductions as a quasi‐natural experiment, we find that heightened competition leads firms to expand their use of strategic alliances. This patt...

Drought responses of a Norway spruce forest on drained peat soil: combining sap-flow sensors, eddy-covariance, meteorological, soil and UAV data

Abstract. The summer of 2021 brought a severe drought to southern Finland. We explored how a drained boreal peatland forest responds to drought by combining a wide range of in situ monitoring and Unmanned Aerial Vehicle (UAV) remote sensing. A dataset combining eddy-covariance (E...

First Serological Evidence of Exposure to Japanese Encephalitis Virus in Feral Pigs and Sentinel Chickens in Western Australia

Japanese encephalitis virus (JEV) emerged across mainland Australia in 2022, causing substantial impacts on public health and the pig industry. Its emergence raised concerns regarding potential spread into Western Australia (WA). This study aimed to determine JEV activity in WA w...

Heat shock transcription factor-1 and heat shock protein 90: insights into post-insemination endometritis

CONTEXT: In mares, post-breeding endometritis is a major cause of embryo mortality. In other species, endometrial function and pathology seem to involve heat shock protein-90 (HSP90), a factor regulated by heat shock transcription factor-1 (HSF-1). AIMS: To study the relationship...

Shared patterns of human milk composition link mammary gland function to infant growth

The mammary gland produces nutrient-rich human milk (HM), yet how mammary functional state shapes HM composition and infant outcomes remains poorly understood. We used HM multi-omics - metabolomics, proteomics, micronutrients, macronutrients, and HM oligosaccharides - across 1,54...

The Leukocyte Landscape Across Mouse Strains and Tissues

ABSTRACT With widespread use of mice ( Mus musculus ) in immunological research, understanding baseline immune variation between mouse models is critical. While peripheral blood immune profiles have been well‐defined, strain‐ and sex‐specific differences in leukocyte composition...

Jetted helical anchor installation as a torque reducing technique

Helical piles and anchors are being increasingly considered for offshore renewable energy applications. However, the very high installation torque required at the scales relevant to offshore use remains a significant barrier to their deployment. This paper investigates a torque-r...

Zn-Modified MoS2 Catalyst for Efficient CO2 Hydrogenation to CH3OH

Abstract Hydrogenation of carbon dioxide (CO2) to methanol (CH3OH) using hydrogen produced from renewable energy sources is a promising pathway for carbon recycling and energy storage. Molybdenum disulfide (MoS2), with its typical layered structure, holds significant industrial p...

Predicting recovery outcomes following mild traumatic brain injury in an Australian community cohort: Results from the Concussion Recovery Study (CREST)

Background Most people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-mo...

Reversible Inhibition of Ammonia Monooxygenase by 1,9-Decanediol Triggers a RegB-RegA-Associated Energy Crisis and Stress Response in Nitrosomonas europaea

Abstract 1,9-decanediol, a rice-derived biological nitrification inhibitor (BNI) suppresses soil nitrification and nitrous-oxide emissions, but the mechanisms of action against ammonia-oxidizing bacteria remain unclear. Combining physiology and transcriptomics in Nitrosomonas eur...

A call for action with the burden of cirrhosis in Australia

Unlike most other chronic diseases and cancers in Australia, outcomes for cirrhosis and hepatocellular cancer are not improving. Public hospitals are overwhelmed by decompensated cirrhosis and struggling to provide best practice care for the large population of patients with less...

The Framework for Policy Decision on the RTS,S/AS01 malaria vaccine: the use of emerging data to inform global policy on the first malaria vaccine

The World Health Organization (WHO)-coordinated Malaria Vaccine Implementation Programme (MVIP) supported pilot introductions of the RTS,S/AS01 malaria vaccine by the ministries of health through the childhood immunization programmes in Ghana, Kenya and Malawi from 2019 through 2...