The University of Texas Medical Branch at Galveston

Persistent Post-Concussion Syndrome After Its Withdrawal from DSM-5 and ICD-11: Definitional Disagreement and the Neurocognitive Gap

A substantial minority of patients do not recover fully after mild traumatic brain injury. Persistent post-concussion syndrome includes both cognitive and non-cognitive manifestations, yet DSM-5 and ICD-11 withdrew the syndrome as a distinct diagnosis and reorganized its persiste...

Colchicine as adjunctive therapy in heart failure: a pooled analysis

Colchicine has shown anti-inflammatory benefits in cardiovascular disease, but its role in heart failure (HF) remains unclear. This systematic review assesses the efficacy of colchicine as an adjunct therapy in heart failure. A systematic search identified randomized controlled t...

Geographic Differences in Rehabilitation Delays for Older Adults Across Rehabilitation Service Areas During the COVID-19 Pandemic

Date presented: April 24, 2026 Primary Author and Speaker: Snaghun Nam, nams@uthscsa.edu

An inducible co-stimulator ligand (ICOSL)-based peptide therapy for proteinuric kidney diseases targeting αvβ3 integrin

Abstract Dysregulated αvβ3 integrin activation in podocytes contributes to proteinuric kidney disease by disrupting podocyte architecture and the glomerular filtration barrier. However, no treatments currently exist that therapeutically target this integrin. We previously identif...

FDG-PET/CT Evaluation of Pulmonary Artery Sarcoma Masquerading as Pulmonary Embolism

A 20-year-old woman underwent evaluation for cardiopulmonary symptoms initially attributed to pulmonary embolism of uncertain chronicity. Positron emission tomography/computed tomography (PET/CT) revealed an intensely fluorodeoxyglucose (FDG)-avid mass within the right pulmonary...

Sexually dimorphic control of excitatory synapse maintenance in ventral hippocampal circuits by Neurexin2α ligand Vstm2b

Abstract Neuronal networks rely on precise synapse formation, maturation, and maintenance orchestrated by synaptic adhesion molecules including α- and β-neurexins (Nrxns). Through unbiased proteomics, we identified Vstm2 family members as α-Nrxn-specific interactors that require...

Long-Term Complications and Secondary Procedures After Open Reduction and Internal Fixation of Ankle Fractures: A Descriptive Epidemiologic Study of Over 50,000 Patients.

Background Ankle fractures account for ~10% of fractures, ~40% treated operatively, yet absolute long-horizon complication and secondary-procedure estimates by fracture pattern and comorbidity remain limited. Prior series generally left decedents in the denominator as though stil...

Clustering Hybrid Functional and Vector Data

ABSTRACT Modern biomedical studies increasingly collect hybrid data, consisting of functional observations (e.g., curves or images) and multiple scalar (vector‐valued) clinical variables. Integrating these modalities in an unsupervised learning framework can improve patient subgr...

Severe burn disrupts tissue-specific clock gene expression in peripheral blood mononuclear cells and skeletal muscle in a rodent model

INTRODUCTION: Severe burns cause systemic inflammation and a hypermetabolic response, yet their impact on biorhythms remains unclear. Clock gene-regulated circadian rhythms maintain physiologic homeostasis and are altered in disease. We posit that severe burn disrupts tissue-spec...

Predictors of Delayed and Omitted Postoperative Radiotherapy After Laryngectomy for pT4 Laryngeal Cancer

BACKGROUND: Postoperative radiotherapy (PORT) improves locoregional control and survival in high-risk head and neck cancer, and guidelines recommend initiation within 42 days of surgery. Timeliness after laryngectomy for pathologic T4 (pT4) laryngeal cancer is poorly characterize...

Acceptability and preference of self-collected vaginal samples for human papillomavirus DNA testing compared with physician-collected Pap smear

BACKGROUND: Self-collected vaginal sampling for human papillomavirus (HPV) DNA testing provides a promising alternative to physician-collected Pap smears, especially in low-resource settings. However, data on its acceptability and preferences among Filipino women remain limited....

Comparative Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Heart Failure and Chronic Kidney Disease

Background Evidence comparing intermediate‐term outcomes of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) in patients with concomitant heart failure and chronic kidney disease remains limited. Methods Using the TriNetX Global Colla...

Anxiety and mood disorders are associated with greater healthcare and procedural utilization in idiopathic intracranial hypertension

Background and purpose Anxiety and mood disorders (AMD) are common in idiopathic intracranial hypertension (IIH), but their association with procedural treatment and healthcare utilization is unclear. We evaluated utilization among patients with AMD documented before or shortly a...

Gut microbial metabolism of immunosuppressive drugs: from metagenomic associations to functional enzyme biomarkers

PURPOSE OF REVIEW: Inter-individual variability in immunosuppressant exposure remains a major challenge in transplantation. Pharmacogenomics and host-related factors contribute to this variability, with increasing evidence suggesting that the gut microbiome is also an important d...

A multi-site benchmarking framework for scalable extraction of geriatric care constructs from electronic health records

Current Natural Language Processing (NLP) algorithms for detecting geriatric conditions are largely limited to domain-specific models that fail to capture the interdependent, multidimensional nature of comprehensive geriatric assessment. This study aimed to develop and evaluate a...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Nutritional optimization for older adults undergoing hip fracture surgery: a randomized controlled pilot trial

Objectives: To identify the incidence of malnutrition in elderly patients with hip fracture, evaluate the impact of a nutritional intervention, and assess feasibility of study design. Design: Randomized controlled pilot trial. Setting: Level 1 trauma center. Patients/Participants...

Antagonism of stress granules is key to SARS-CoV-2 infection and pathogenesis

ABSTRACT Viruses must subvert host responses to facilitate successful infection. While most antiviral responses are associated with interferons, stress granules (SGs) are another barrier to viral infection by inducing translation arrest. To combat SG activity, viruses have evolve...

Clinical Characteristics and Outcomes of Melanoma Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elderly Population: A Cohort Analysis Over 10 Years

Introduction: Outcomes among the Hispanic population are rarely explored in adolescents and young adults (AYAs). We aimed to compare sociodemographic, clinical, and survival outcomes of Latin American AYAs (≤39 years) with middle-aged (40–59 years) and older (≥60 years) patients...

PIWIL4 regulates gene expression and piRNA levels in RSV-infected airway epithelial cells

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections with significant morbidity and mortality in young children, the elderly and immunocompromised hosts. Despite its clinical burden, no effective RSV vaccine or therapy exists for infant...