Institution
The University of Texas Health Science Center at Houston
Recent research
- BiologyOpen access
Normally, the “flip-flop” motion is reserved for small lipid molecules which move from one leaflet of the membrane to the other, and even that process is very slow without the aid of specific enzymes. Unexpectedly, we recently found that despite a prohibitively high energy barrie...
- Health & Medicine
Background: Visual input is crucial for stable gait, particularly in individuals with transfemoral amputation (TFA) who lack somatosensory feedback from their TFA limb. Low-light conditions may further influence their walking patterns, increasing the risk of falls and joint disor...
- Health & MedicineOpen access
Innate immune responses in Caenorhabditis elegans are regulated by multiple effectors that are activated upon bacterial exposure. In this study, we investigated the role of pgp-5, a transmembrane efflux transporter implicated in cellular stress responses and detoxification in hos...
- Health & Medicine
Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...
- Health & MedicineOpen access
Complete data and analysis package for a systematic review and meta-analysis of peripheral immune biomarkers in bipolar disorder, focused on the interleukin-23/T-helper-17 axis (PROSPERO CRD420261434475). The deposit contains the extraction layer (one row per reported group stati...
- Health & MedicineOpen access
Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers
Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...
- BiologyOpen access
The circulating lipidome in severe obesity
Severe obesity (SevO; BMI ≥ 40 kg/m 2 ) is rising globally yet remains understudied mechanistically. To characterize lipidomic alterations at the species level, we analyzed Border Health Research Cohort participants with fasting plasma lipidomics and genetic data, comparing SevO...
- Health & MedicineOpen access
Background Food insecurity affects 2.33 billion people worldwide and disproportionately impacts those with inflammatory bowel disease (IBD). However, population-level evidence linking food insecurity and gastrointestinal (GI) conditions remains limited. Aim To examine the associa...
- Health & MedicineOpen access
Deep whole genome sequencing of epileptogenic brain lesions
Abstract Objective Malformations of cortical development and low‐grade epilepsy‐associated tumors often cause drug‐resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information a...
- AI & ComputingOpen access
BACKGROUND: Electronic health records (EHRs) collected from diverse healthcare institutions offer a rich and representative data source for clinical research. Federated learning enables analysis of these distributed data without sharing sensitive patient-level information, preser...
- Health & MedicineOpen access
Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...
- BiologyOpen access
Altered saccade control reveals executive dysfunction in late-life depression
Late-life depression (LLD) is frequently accompanied by executive dysfunction, which is associated with poorer clinical outcomes but remains difficult to assess objectively in older adults. Saccadic eye movements provide a rapid and non-invasive approach for probing executive-con...
- Health & MedicineOpen access
= 81). The MiniOmni was the QUS device, and the smallest probe, CS probe (length 24 mm, range 2200-4700 m/s, and max depth 4.5 mm), was used for all subjects. Measurements were taken at the mid-tibia location. Inter-rater reliability was calculated using 2-way random-effects intr...
- BiologyOpen access
Human tumor-associated microbes – the tumor microbiome – have demonstrated an increasingly important role in human health due to their relevance to cancer progression and treatment response. While the metabolism at the host-microbiota interface, such as in the human gut, has been...
- Health & MedicineOpen access
Trends in Metabolic and Bariatric Surgery Procedure Volume Recorded in MBSAQIP, 2015–2024
BACKGROUND: Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity; however, national procedure volume is not well characterized. We examined trends in MBS utilization in the United States from 2015 to 2024 using the Metabolic and Bariatric Surge...
- Health & MedicineOpen access
Study Design Systematic review and diagnostic accuracy meta-analysis. Objective To evaluate the diagnostic accuracy of intraoperative neurophysiologic monitoring (IONM) for detecting postoperative neurologic deficits in spinal deformity surgery and assess performance across monit...
- Health & MedicineOpen access
Background and Objectives: Penile prosthesis infection usually ends in device removal, whereas unnecessarily broad or prolonged prophylaxis causes toxicity and promotes resistance. We assessed whether the systemic perioperative antibacterial or antifungal strategy, dose or durati...
- Society & EconomicsOpen access
Firearm owners’ support for policies regulating firearms left in vehicles
Abstract Purpose Firearms stolen from vehicles are a leading source of gun theft in the US. In response, there has been growth in the number of proposed and enacted policies at the state and local levels. Yet firearm owners’ attitudes toward policies regulating firearms left in v...
- Health & Medicine
BACKGROUND: Distal interphalangeal joint (DIPJ) arthrodesis is the treatment of choice for DIPJ arthritis when conservative measures fail. However, open arthrodesis and non-reamed percutaneous techniques have been associated with high rates of nonunion and complications. This stu...
- Health & MedicineOpen access
Post-operative complications during the 90-day global period are a concern after primary total joint arthroplasty (TJA), especially in high-risk patients. Biological wound powders, such as collagen with extracellular matrix/proteins (Xcellistem), may enhance wound healing. This s...