The University of Adelaide

A call for action with the burden of cirrhosis in Australia

Unlike most other chronic diseases and cancers in Australia, outcomes for cirrhosis and hepatocellular cancer are not improving. Public hospitals are overwhelmed by decompensated cirrhosis and struggling to provide best practice care for the large population of patients with less...

Chern-Weil theory for singular Haefliger foliations

We give a Chern-Weil map for the Gel'fand-Fuks characteristic classes of densely regular foliations, those foliations defined by smooth Haefliger structures with dense regular set. Our characteristic map constructs, out of singular geometric structures adapted to singularities, e...

Loss of RafE impairs raffinose utilization and increases early pneumococcal burden in mice

ABSTRACT Streptococcus pneumoniae (the pneumococcus) is one of the most common bacterial causes of middle ear infections (otitis media) in children. These infections are highly prevalent but can be persistent and challenging to treat. The pneumococcus is a highly genetically dive...

The limits of Antarctic conservation governance

Abstract The Antarctic region exerts a profound influence on the Earth system, making its conservation fundamental to sustaining planetary health and human wellbeing. The Antarctic Treaty System (ATS) holds near-exclusive authority for environmental protection across the region,...

Questionable Evidence for Berberine in Polyendocrine Metabolic Ovarian Syndrome: An Integrity-Based Reappraisal

Prior systematic reviews suggest that berberine may match or exceed the effects of metformin on metabolic and hormonal outcomes in polyendocrine metabolic ovarian syndrome (PMOS; previously referred to as polycystic ovary syndrome). This review aimed to assess the reported effica...

Aligning climate policy with energy justice through remedial stakeholder theory

We contribute to this special issue by exploring climate policy and energy justice through the lens of remedial stakeholder theory. While stakeholder theory traditionally focuses on present and forward-looking relationships, we argue that climate change and the energy transition...

Evaluating collector behaviour in coarse particle flotation of copper ores

Most studies on collectors for copper flotation focus on conventional mechanical cells and fine particle sizes (<150 µm), leaving limited understanding of collector performance in coarse particle flotation. This study investigates the performance of four collector classes in the...

Cross-Boundary Practices within the Construction Industry: The Case of the Quantity Surveyors

Abstract The evolving dynamics of the construction industry have sharpened the need for quantity surveyors (QSs) to reinterpret their role, expanding beyond traditional commercial management practices to encompass broader strategic functions such as value optimization and interdi...

Silicon-mediated alleviation of salinity stress in wheat is linked to reduced sodium accumulation but depends on cultivar and silicon source

Abstract Background and aims Soil salinity constrains crop productivity globally, yet mitigation strategies often involve economic or environmental trade-offs. Silicon (Si) supplementation is a potential approach to alleviate salinity stress, although responses are inconsistent a...

A 30-year Polish cohort study covering the COVID-19 pandemic period indicates shifts in the age of infants’ motor development milestones

Abstract Infants’ motor development is influenced by genetic and environmental factors. The objective of this study is to investigate whether there are differences in the age of gross motor skill development between cohorts observed over a 30-year period, and if these differences...

Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women’s cerebrovascular health

Cerebral venous sinus thrombosis (CVST) and carotid web (CW) are distinct cerebrovascular disorders where vascular geometry, disturbed hemodynamics, and endothelial activation interact to drive thrombosis. Both conditions disproportionately affect women, yet remain understudied b...

Oscillopathic features and neuromodulation with tACS in people with Parkinson’s disease: A semi-systematic review

Parkinson's disease (PD) is associated with prominent changes in neural oscillatory activity. These occur at cortical and subcortical sites, strongly predict clinical deficit, and are normalised by therapy. Interventions targeting oscillatory activity therefore represent an avenu...

Antimicrobial resistance in the monotreme microbiome

Context Antimicrobial resistance (AMR) is a global health crisis requiring a One Health approach that recognises the interconnectedness of people, animals and the environment. Since wide adoption of the One Health framework, wildlife species have been identified as important pote...

Kidney Donation After Circulatory Death Is Associated With Sustained Graft Function, Comparable Graft, and Patient Survival.

Background: Kidney transplantation is the preferred treatment for kidney failure, offering various benefits, yet donor supply remains limited worldwide, including in Australia and New Zealand. We examined long-term outcomes of kidney transplant recipients from donation after circ...

Multi-layer network analysis of deliberation in an online discussion platform: The case of Reddit

This paper proposes a novel multi-layer network model to study deliberation in online discussion platforms. The model comprises two layers: a discussion layer, which represents as a hierarchical tree the comment-to-comment replies within a given post, and an actor layer, which re...

Negotiating AI integration in higher education curricula: Coping behaviour or career opportunity?

This study examines how higher education educators perceive artificial intelligence (AI) as both a coping resource and a catalyst for career development. Grounded in the Stimulus-Organism-Response (S-O-R) framework and integrating Social Cognitive Career Theory (SCCT) with Lazaru...

A Bourdieusian study of international students’ lifeworlds: multiplicity in a “twisted space”

This study explores the tensions and dynamics embedded in the lifeworlds of international students. Data were drawn from an Australian study, including interviews with 16 international students and nine community members supporting international students through their professiona...

Corticosteroid use in children with community acquired sepsis: a multicentre prospective cohort study

Objectives Corticosteroids in paediatric sepsis have the potential to improve outcomes, yet there is little supporting evidence regarding efficacy, choice of agents, dose or timing of administration. We describe the patterns of corticosteroid use in children hospitalised with sus...

Middle-Down Mass Spectrometry Characterization of Monoclonal Antibody Enabled by Electron-Activated Dissociation on a Time-of-Flight Platform: A Case Study of Methionine Oxidation PTM Identification and Quantification

Abstract Characterizing post-translational modifications (PTMs) in monoclonal antibody products is critical for ensuring product quality attributes understanding and monitoring. While the bottom-up approach is widely adopted, it suffers from the loss of molecular connectivity and...

Quantitative single cell analysis of gold nanoparticle association across a mouse triple-negative breast cancer cell line and blood immune cell populations

In biomedical research, understanding the heterogeneity in nanoparticle association among different cell populations is crucial for translating to efficacy and immune identification. Using time-of-flight mass cytometry (CyTOF), we quantitatively assessed the association and distr...