The People's Hospital of Guangxi Zhuang Autonomous Region

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice

Abstract Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly...

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...

Escalating global burden of female infertility

This study explores the global burden of female infertility across 204 countries and 21 regions from 1990 to 2021. The population-based study analyzed was conducted using data from the Global Burden of Disease 2021. We assessed age-standardized prevalence rate (ASPR), age-standar...

Renal microcirculatory impairment on contrast enhanced ultrasound predicts persistent renal impairment in cardiogenic shock patients receiving venoarterial extracorporeal membrane oxygenation

Abstract Acute kidney injury (AKI) is one of the most frequent complications in patients with cardiogenic shock (CS) receiving veno‑arterial extracorporeal membrane oxygenation (VA-ECMO). Microcirculation dysfunction is an important mechanism and it can be effectively evaluated b...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Metabolomics of immunosenescence: bridging blood biomarkers and metabolic pathways in aging

Immunosenescence—the progressive decline in immune competence with advancing age—contributes substantially to increased infection susceptibility, reduced vaccine efficacy, and heightened chronic inflammatory disease burden in older adults. Despite extensive characterization of im...

Association between lipid accumulation product index (LAP index) and coronary artery disease risk

Coronary artery disease (CAD) is a highly prevalent condition that predominantly affects obese individuals and those with metabolic abnormalities. The lipid accumulation product (LAP), combining waist circumference (WC) and triglyceride (TG) measurements, provides a clinically re...

Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes

Background As a major cause of global mortality, heart failure (HF) has mechanisms that remain elusive. Recent studies suggest β-hydroxybutyrylation (Kbhb) may contribute to its pathogenesis, driving this investigation into Kbhb-associated HF biomarkers. Methods We collected HF-a...

Antioxidant/Antibacterial Nanofibers Loaded with Liposome-Encapsulated Proanthocyanidin Complexes: Machine Learning-Optimized Liposome Incorporated in Nanofibers Promotes Antibiotic-Free Wound Healing

Abstract Existing wound dressings are inherently limited by their insufficient antioxidant capacity, which fails to modulate the excessive oxidative stress at the injury site, alongside the well-recognized risks of bacterial infection and the escalating threat of antibiotic resis...

Unraveling the bidirectional interplay of the gut microbiota with chemotherapy and radiotherapy in colorectal cancer: from pathogenesis to probiotic interventions

Colorectal cancer remains a leading cause of cancer-related mortality worldwide. While chemotherapy and radiotherapy serve as a cornerstone of treatment, their clinical efficacy is frequently compromised by therapeutic resistance and gastrointestinal toxicity. Accumulating eviden...

Dynamic Echocardiographic Trajectory Phenotypes During Veno‐Arterial Extracorporeal Membrane Oxygenation and Their Association With In‐Hospital Mortality: A Multicenter Cohort Study

BACKGROUND: Current risk stratification for veno-arterial extracorporeal membrane oxygenation relies on static assessments, ignoring dynamic cardiac evolution. We aimed to identify longitudinal echocardiographic trajectory phenotypes and evaluate their association with in-hospita...

Environmental and system-level factors associated with emergency medical service utilization and immediate on-scene symptom response: a population-based study

Abstract Background Suspected cardiopulmonary emergencies represent a major component of EMS demand and are highly sensitive to environmental exposures. However, the combined impact of these dual macro-environmental and micro-operational stressors on prehospital treatment effecti...

Patients’ perceptions of male and female nursing interns in Guangdong and Guangxi, Southern China

Nursing remains female-dominated globally, with gender stereotypes hindering workforce diversity. Male nurses account for 2% to 5% of China’s nursing workforce, and Guangdong/Guangxi lack studies on patients’ perceptions of male nursing interns. This study aims to explore relatio...

Epidemiological characteristics of hospitalized injury patients in a tertiary hospital of Guangxi Zhuang Autonomous Region, China: a retrospective single-center observational study

Abstract Background Injury is a substantial public health issue that ranks among the primary causes of mortality and disability globally. This study aimed to analyze the epidemiological characteristics and types of injury among hospitalized patients through a single-center hospit...

Multi-omics profiling of migraine links plasma proteomic signatures with lipid metabolomic measures

Migraine is a highly prevalent neurological disorder with incompletely understood molecular mechanisms. We aimed to identify migraine-associated plasma proteins and lipid metabolomic measures and to investigate their relationships through an integrated multi-omics framework. This...

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Single-blastomere next-generation sequencing confirms chromosomal abnormalities as the primary cause of impaired developmental potential in embryos with abnormal cleavage patterns

Abnormal cleavage impairs embryonic development, but the effects of different abnormal cleavage patterns and occurrence stages remain unclear. Previous chromosomal analyses at the blastocyst stage have failed to elucidate the underlying mechanism. This study investigated the effe...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

Breast metastasis from BRCA1-mutated ovarian cancer: response to parp inhibition and a potential lymphatic route

Abstract Background Breast metastasis from extramammary malignancies is rare, with ovarian cancer being an exceptionally uncommon primary source. These metastases frequently mimic primary breast carcinoma, posing substantial diagnostic and therapeutic challenges. Case presentatio...

Burden of Crohn’s disease in East Asia: a 34-year analysis with projections to 2060

Abstract Purpose Crohn’s disease has transitioned from a rare condition to a significant public health concern in East Asia, yet comparative evidence across countries and long-term projections remain limited. We assess national trends in the burden of Crohn’s disease in China, Ja...