The People's Hospital of Guangxi Zhuang Autonomous Region

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Single-blastomere next-generation sequencing confirms chromosomal abnormalities as the primary cause of impaired developmental potential in embryos with abnormal cleavage patterns

Abnormal cleavage impairs embryonic development, but the effects of different abnormal cleavage patterns and occurrence stages remain unclear. Previous chromosomal analyses at the blastocyst stage have failed to elucidate the underlying mechanism. This study investigated the effe...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

Breast metastasis from BRCA1-mutated ovarian cancer: response to parp inhibition and a potential lymphatic route

Abstract Background Breast metastasis from extramammary malignancies is rare, with ovarian cancer being an exceptionally uncommon primary source. These metastases frequently mimic primary breast carcinoma, posing substantial diagnostic and therapeutic challenges. Case presentatio...

Burden of Crohn’s disease in East Asia: a 34-year analysis with projections to 2060

Abstract Purpose Crohn’s disease has transitioned from a rare condition to a significant public health concern in East Asia, yet comparative evidence across countries and long-term projections remain limited. We assess national trends in the burden of Crohn’s disease in China, Ja...

Organising cross-border care after arrival: receiving-system challenges in a China–Vietnam border region

Cross-border healthcare is increasingly visible in border regions where patient mobility develops faster than the institutional arrangements needed to support care. Existing research has often examined why patients seek care abroad, while less is known about how receiving health...

Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants

2′,5’ oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation of antigen processing cells to trigger ad...

Adherence to the DASH diet moderates the association between sedentary time and the risk of obstructive sleep apnea in a hypertensive rural Chinese population: a cross-sectional study

Obstructive sleep apnea (OSA) and hypertension form a vicious cycle. While sedentary behavior is an emerging risk factor for OSA, and the dietary approaches to stop hypertension (DASH) diet offers cardiometabolic benefits, their interplay in non-obese hypertensive patients remain...