The Ohio State University Wexner Medical Center

Pharmacotherapy for MASLD/MASH: approved therapies, drug repurposing, and emerging mechanism-based candidates

INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis (MASLD/MASH) pharmacotherapy is changing rapidly after the approval of resmetirom and semaglutide for selected adults with noncirrhotic MASH and F2-F3 fibro...

Pimicotinib versus placebo in tenosynovial giant cell tumor (TGCT): a plain language summary of the MANEUVER clinical trial

Plain Language SummaryWhat is this summary about?This summary describes the main findings of the MANEUVER clinical trial for pimicotinib, a once-daily treatment. The goal was to see if pimicotinib could significantly reduce tumor size after 24 weeks of treatment in clinical trial...

A second chance? Outcomes of immunotherapy retreatment after prior checkpoint inhibitor exposure in endometrial and cervical cancer

OBJECTIVE(S): As immunotherapy (IO) is increasingly utilized for treatment of endometrial cancer (EC) and cervical cancer (CC), optimal treatment strategies after IO remains poorly defined. We evaluated clinical outcomes, treatment patterns, toxicity, and survival among patients...

Myocardial work in light-chain and transthyretin-related amyloidosis with preserved ejection fraction: a cardiovascular magnetic resonance study

Abstract Objectives To investigate pressure–volume loop (PV-loop) changes by cardiovascular magnetic resonance (CMR) imaging in cardiac amyloidosis (CA) patients with preserved left ventricular ejection fraction (LVEF), and to assess PV-loop parameters’ potential as subtype diffe...

Treatment Fidelity of AquOTic: An Occupational Therapy-Based Aquatic Intervention for Children on the Autism Spectrum

Importance Children on the autism spectrum face significantly higher risks for unintentional drowning, yet aquatic interventions often lack the standardized specification necessary for evidence-based replication. Objective To examine the treatment fidelity of AquOTic. Design Desc...

Prenatal stress reprograms placental signaling and opposes maternal immune activation effects in the fetal brain

Abstract Prenatal psychosocial stress and maternal immune activation (MIA) increase risk for overlapping offspring psychiatric disorders, but whether they influence fetal neurodevelopment through shared or distinct mechanisms is unclear. Positioned at the interface of maternal an...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

CORAL: a machine learning algorithm to identify coronary microvascular disease from doppler coronary blood flow patterns

The direct diagnosis of coronary microvascular disease (CMD) in patients has remained elusive, relying on combinatorial criteria for diagnosis. Recent data in mice suggested that coronary blood flow (CBF) patterns harbor “fingerprints” that may be novel non-invasive indicators of...

Measurement of trainee autonomy in robotic-assisted lung resections using objective performance indicators

Abstract Trainee autonomy in robotic-assisted thoracic surgery is critical for growth but difficult to quantify. Robotic platforms can log intraoperative kinematic and event data that can be transformed into metrics known as objective performance indicators (OPIs). This study sou...

Anatomical and Histologic Response to Neoadjuvant Therapy: Recurrence Patterns Among Poor Responders. A Multi-institutional Observational Cohort Study.

OBJECTIVE: To characterize the prognostic implications after hepatectomy for colorectal liver metastases (CRLM) by integrating anatomical response to neoadjuvant therapy (NAT), quantified using the Tumor Burden Score ratio (TBSr), with histologic response assessed by Tumor Regres...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma

We investigated the role of tumor microenvironment (TME) in evolution of liver cirrhosis to hepatocellular carcinoma (HCC). Nonmalignant hepatic tissues, including chronic hepatitis and cirrhosis, retained expression of liver specific miR-122 and hepatocyte nuclear factor 4 (HNF-...

Geospatial Links Between Pediatric LRTI Acute Care Use and the Child Opportunity Index

BACKGROUND AND OBJECTIVES: Neighborhood social determinants influence pediatric acute care (AC) use, but their role in lower respiratory tract infections (LRTIs), the leading cause of pediatric hospitalization, is unclear. We mapped LRTI AC utilization and examined whether census...

Community priorities for programs using HIV molecular epidemiology: A best-worst scaling

Background: HIV molecular epidemiology (HIV-ME) uses genetic sequencing to study viral evolution, detect transmission clusters, and guide public health responses. Ethical, legal, and social implications of HIV-ME have been raised, yet quantitative evidence on community perspectiv...

Cost analysis of venous stent reconstruction in the treatment of chronic lower extremity venous occlusive disease

As healthcare costs approach 20% of the United States’ gross domestic product, accurate healthcare cost accounting has become increasingly important [ 1 ]. Increases in the direct cost of hospital-based care have been predominant drivers of overall healthcare spending [ 1 , 2 , 3...

Defining priorities for care among young adults diagnosed with breast cancer

Abstract Introduction Breast cancer is a leading cause of cancer‐related mortality among young adults (YAs) aged 18–39 years. Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are l...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection

Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflam...

Cost and transportation barrier trends related to Affordable Care Act among cancer survivors and atherosclerotic cardiovascular disease patients

The Affordable Care Act (ACA) included major coverage expansions implemented in 2014. However, its association with cost‑related barriers among people with chronic disease remains incompletely described. We analyzed trends in cost and transportation related barriers to care betwe...