The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation

BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...

A second chance? Outcomes of immunotherapy retreatment after prior checkpoint inhibitor exposure in endometrial and cervical cancer

OBJECTIVE(S): As immunotherapy (IO) is increasingly utilized for treatment of endometrial cancer (EC) and cervical cancer (CC), optimal treatment strategies after IO remains poorly defined. We evaluated clinical outcomes, treatment patterns, toxicity, and survival among patients...

Cytokine Profiles in Cervical Intraepithelial Neoplasia: Associations with Lesion Severity and Exploratory Treatment Response

Background: Persistent infection with high-risk human papillomavirus (hrHPV) is the principal cause of cervical intraepithelial neoplasia (CIN). Cytokines regulate antiviral immunity and tissue remodeling, and cytokine profiling may provide additional information about the biolog...

The chromatin-organizer Satb1 modulates regulatory T cell activity within the tumor microenvironment

Regulatory T cells (Tregs) are essential for maintaining immune homeostasis and preventing autoimmune diseases, but are also a major cellular constituent of the tumor microenvironment (TME) that facilitates cancer progression. Identifying differences in Treg subtypes to specifica...

Anomalous Pigmentation in Depigmented Murine Hairs from Neutron Radiation Exposure

Abstract Depigmentation in mouse hair is a long-studied consequential effect of radiation exposure. In this study, changes in hair pigmentation in C57BL/6 mice are observed at time points more than 90 days following neutron irradiation. A mixed sex cohort of C57BL/6 mice (N = 40)...

Defining priorities for care among young adults diagnosed with breast cancer

Abstract Introduction Breast cancer is a leading cause of cancer‐related mortality among young adults (YAs) aged 18–39 years. Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are l...

Longitudinal plasma neurofilament light chain and patient-reported outcomes as complementary markers of vincristine-associated peripheral neuropathy in adults with lymphoma: a cohort study

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxicity of cancer treatment with limited diagnostic, monitoring, and treatment options. Neurofilament light chain (NfL) is an axonal cytoskeletal protein released during neuroaxonal injury and a promisin...

Development and Validation of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS) Among Adult Dual Users

BACKGROUND: The present study aimed to develop and evaluate the preliminary validity of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS), a new measure designed to assess the level of stress burden associated with the co-occurring perceptions of electronic cigaret...

Psychological distress in adult patients with colorectal cancer: roles of biological age and neighborhood deprivation

Abstract Introduction Depression and anxiety are common in adults with colorectal cancer (CRC), especially during chemotherapy, yet underlying biosocial mechanisms remain unclear. We examined whether biological age predicts these symptoms and whether neighborhood deprivation ampl...

Functionally active lymphoid aggregates correlate with improved prognosis in brain metastases

Abstract B cells and their cellular neighborhoods, i.e., lymphoid aggregates (LAs) and tertiary lymphoid structures (TLS), have not been extensively studied in melanoma brain metastases (BM) or lung adenocarcinoma (LUAD) BM, despite their prognostic value and role in immunotherap...

Caring for Young Adults with Breast Cancer: Providers’ Perspectives on Burnout in a Complex Care Landscape

PURPOSE: While challenges faced by young adults (YAs) aged 18-39 years with breast cancer are well-documented, health care providers' experiences caring for YAs are underinvestigated. Given high burnout rates among oncologists, this study explores providers' perspectives about ho...

P1.240. Anastomotic Technique for Two-Stage Oesophagectomy: A Single-Centre Evaluation Following Introduction of a Robotic Programme

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Anastomotic leak remains one of the most consequential complications following oesophagectomy, driving morbidity, mortality, and prolonged recovery. Anastomotic technique is a key mod...

The majority of 5hmC is nucleosome-associated in naïve B cells

DNA demethylation is essential for gene activation and is primarily mediated by the Ten-Eleven-Translocation (TET) dioxygenase family. TET initiates demethylation by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a chemically stable derivative that is not onl...