The George Institute for Global Health

High sensitivity C-reactive protein and the risk of cardio-kidney outcomes in adults with moderate to severe chronic kidney disease: a nationwide study

BACKGROUND AND HYPOTHESIS: The burden and prognostic significance of inflammation in chronic kidney disease (CKD) remains poorly characterized, with prior studies yielding conflicting estimates of the association between elevated high-sensitivity C-reactive protein (hsCRP) and ca...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Hypertension detection, treatment and control in young adults in Australia

Young adult hypertension increases risk of future cardiovascular disease but is often overlooked. We aimed to identify opportunities to reduce blood pressure among younger adults by determining the drivers of hypertension detection, treatment and control in young adults in Austra...

Listen to Your Heart and Mind: A Pilot Mixed‐Methods Study on Combined Screening for Raised Blood Pressure, Atrial Fibrillation, Cognitive Impairment and Hearing Loss in Older Adults

ABSTRACT Objective To determine the potential feasibility and acceptability of combined screening for raised blood pressure (BP), atrial fibrillation (AF) and cognitive impairment (CI) in older adults within a setting of hearing health assessment for detection of hearing loss. Me...

Patient perspectives on cardioprotective medication during breast cancer treatment

Cardiotoxicity remains a key concern of HER2-directed therapies, with no proven prevention strategies. The success of cardioprotective interventions will depend not only on efficacy, but on patient acceptability, an underexplored determinant of trial participation and clinical im...

Impact of a Mediterranean diet and physical activity intervention on the gut microbiome and faecal metabolites: findings from the MedEx-UK randomised controlled trial

Abstract Diet and physical activity (PA) are potential modulators of the gut microbiome, although research findings are inconsistent, and few studies have explored their combined effects. This study used data from ninety-three participants (forty-seven with pre- and post-interven...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

An Equity Analysis of the Prevalence, Costs and Coping Mechanisms of Informal Payments in the Utilisation of Healthcare Services in Nigeria

ABSTRACT Background Informal payments in healthcare facilities increase the cost of services, negatively impacting access and utilisation, particularly for poor and vulnerable populations. However, those affected may adopt various coping strategies to alleviate the financial burd...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

The development and initial validation of the Perinatal Intrusions Interpretation Index: A novel scale that measures negative appraisals of infant‐related intrusive thoughts

OBJECTIVES: Unwanted and often distressing intrusive thoughts of infant-related harm are common during the perinatal period and are associated with poorer maternal mental health. The mechanisms linking perinatal intrusive thoughts to mental health remain poorly understood. One pr...

A cost-effectiveness analysis of selective decontamination of the digestive tract in mechanically ventilated patients in the intensive care unit

Objective To evaluate the 24-months cost-effectiveness of selective decontamination of the digestive tract (SDD) versus standard care in mechanically ventilated Intensive Care Unit (ICU) patients. Design Within‑trial cost‑effectiveness analysis using linked administrative healthc...

Combinations of stepping intensity and daily step counts against all-cause and cardiovascular disease mortality: insights from a device-based prospective study

Objective Understanding the joint role of stepping intensity and step counts could inform pragmatic step-based physical activity strategies for premature mortality prevention. We examined the joint association of stepping intensity and daily step counts with all-cause mortality (...

Unsafe after dark? Women's travel experiences while walking, cycling and using public transport in Australia and New Zealand

Women experience distinct safety challenges when walking, cycling, and using public transport, particularly after dark and in relation to unwanted behaviours. Contemporary evidence integrating multiple transport modes and whole-journey stages across Australia and New Zealand rema...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Characteristics of Vaping Prevention Advertisements: Are Evidence-Based Approaches Being Adopted?

PurposeHealth communication campaigns are an effective and widely used approach to changing health-related behaviours and thus represent a potential means by which vaping among young people can be addressed. To inform the development of future campaigns, this study aimed to docum...

The Association of Umbilical Cord Blood Neurofilament Light With Nonreassuring Fetal Status: A Prospective Observational Study

( Int J Gynaecol Obstet . 2026 Mar;172(3):1491–1500. doi:10.1002/ijgo.70421) A prospective observational study explored whether neurofilament light (NfL), a marker of neuronal injury, can be reliably measured in umbilical cord blood and whether it is associated with nonreassuring...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

Knowledge of and preferred legal grounds for abortion in Kenya: a national cross-sectional telephone survey

Inadequate knowledge of abortion law in restrictive settings impedes women’s access to safe services and engenders poor abortion perception and stigma among the general population. There is limited understanding of the public’s knowledge and support for abortion in Kenya. This st...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...