The First People’s Hospital of Lianyungang

The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis

Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...

Heavy metal exposures and constipation among United States adults

Constipation is a common gastrointestinal disorder that can substantially impair quality of life. Environmental exposure to heavy metals has been implicated in gastrointestinal dysfunction; however, population-based evidence regarding their associations with constipation remains...

Morphologic and hemodynamic risk factors for paraophthalmic segment aneurysm rupture

To evaluate the impact of morphologic and hemodynamic characteristics on paraophthalmic segment aneurysms (PSAs) with the goal of identifying reliable risk factors for PSAs rupture. A case-control study was conducted among patients with a newly diagnosed PSAs who were treated at...

Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study

BACKGROUND: Influenza, a prevalent disease, significantly threatens public health. Accurately predicting severe influenza occurrences is crucial for developing personalized prevention strategies and treatment plans. AIMS: This study aimed to construct a highly interpretable model...

SASI compared with SG-JJB for obese diabetic rats: an experimental comparative study on weight reduction, glycemic control, and postoperative complications

To compare the weight loss, glycemic control, and complication rates of three surgical procedures-sleeve gastrectomy combined with single-anastomosis sleeve ileal bypass (SASI), sleeve gastrectomy with jejuno-jejunal bypass (SG-JJB), and sleeve gastrectomy (SG) alone-in obese dia...

Neutrophil to lymphocyte ratio at stoma site predicts colorectal cancer prognosis

This research examines the connection between the neutrophil-to-lymphocyte ratio (NLR) observed at the stoma site and the prognostic outcomes in patients with colorectal cancer, in comparison to individuals without cancer. By conducting a retrospective analysis of clinical record...

Application effect of PBL combined with skeletal simulation-based surgical training teaching mode in orthopedic teaching

Orthopedics is a highly practical clinical discipline, and traditional single problem-based learning (PBL) teaching is limited by the lack of intuitive operational training, which easily leads to the disconnection between theoretical learning and clinical practice in medical stud...

The impact of enhanced recovery after surgery on postoperative recovery in patients with distal gastric cancer combined with diabetes

To explore the effects of enhanced recovery after surgery (ERAS) on postoperative gastrointestinal function recovery, inflammatory response, and blood sugar-related indicators in patients with diabetes combined with distal gastric cancer. This study used a prospective, non-blinde...

Expression and functional analysis of CDH11 and CDH22 in low-grade glioma

Low-grade glioma (LGG) is a heterogeneous central nervous system tumor with limited reliable prognostic biomarkers and targeted therapeutic strategies. The roles of cadherin superfamily members CDH11 and CDH22 in LGG pathogenesis and progression remain poorly elucidated. Herein,...

Palladium-Catalyzed Narasaka–Heck Carbonylation Using Cr(CO)6 as Carbonyl Source: Access to Ester-Containing Pyrrolines

Abstract An unprecedented Pd-catalyzed CO gas-free Narasaka–Heck carbonylation using Cr(CO)6 as a convenient carbonyl source has been developed for the step-economic construction of ester-containing pyrrolines. Notably, this method overcomes the limitations of conventional radica...

Band-like marginal gingival necrosis as the initial manifestation of acute monocytic leukemia: a case report

Oral manifestations may precede the diagnosis of acute myeloid leukemia (AML), particularly in monocytic subtypes, but the typical findings are gingival enlargement, spontaneous bleeding, petechiae, or nonspecific ulceration. Band-like necrosis confined to the gingival margins an...

Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial

Abstract Background Surgical resection is central to colorectal cancer management, but surgery and anesthesia can induce perioperative immunosuppression. Opioids, a mainstay of perioperative analgesia, may impair cellular immunity, including disruption of Th1/Th2 immune equilibri...

Multi-omics insights into the mechanisms and prognosis of IPF

Abstract Idiopathic pulmonary fibrosis (IPF) represents another progressive and devastating interstitial lung disease found across populations, with a prominent male predominance accounting for approximately 70% of cases. Regional variation in IPF-related genetic polymorphisms, e...

Generative geospatial modelling with geometric algebra

Abstract The integration of data-driven and knowledge-driven approaches in generative geospatial modelling (GGM) is often hindered by their mathematical incompatibilities. Here, we propose a geometric algebra (GA)-based framework that employs a unified multi-vector representation...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...