Texas Children's Hospital

When They Stop Coming: Key Factors in Pediatric BCHD Adherence in Microtia Patients

OBJECTIVE: To analyze the demographic and clinical factors associated with adherence to bone conduction hearing device follow-up care in pediatric patients with microtia and aural atresia. METHODS: Retrospective chart review of 127 patients in a tertiary care microtia database (2...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...

Beyond The Usual Suspects: A Teenager's Diagnostic Odyssey

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The Modern Urology Pipeline: Career Trajectories of Recent Residency Graduates

INTRODUCTION: Urology residency graduates face a pivotal transition when deciding on fellowship training and eventual practice setting. While traditionally a fellowship was a gateway to academia, recent trends reveal increasing pursuit due to job market concerns and perceived gap...

Global trends in pediatric Mycoplasma pneumoniae pneumonia research

Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia in children, most commonly affecting school-aged children from 5 to 17 years old, with periodic increases in M. pneumoniae infections occurring every 3–5 years. 1 , 2 However, like other respiratory pathogen...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Recurrent Sterile Polyserositis Reveals an Underrecognized Autoinflammatory Phenotype in MECP2 Duplication Syndrome

MECP2 duplication syndrome (MDS) is a rare neurogenetic disorder characterized by neurodevelopmental delay, epilepsy, gastrointestinal dysfunction, and frequent infections. The broader spectrum of immune dysregulation remains poorly understood. We retrospectively reviewed four MD...

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...

Emergency Department Predictors of Mechanical Ventilation in Pediatric Spine Fracture Patients in the US

Study DesignRetrospective cohort study.ObjectivesTo identify emergency department variables associated with mechanical ventilation among pediatric patients with spine fractures and characterize outcomes by ventilation duration.MethodsWe queried the National Trauma Data Bank from...

Clinical Characteristics and Risk Factors of Pediatric Thyroid Eye Disease

Purpose: To characterize the natural history and clinical characteristics of thyroid eye disease (TED) in a pediatric population and identify risk factors contributing to disease onset and severity. Methods: A retrospective cohort study was conducted among children diagnosed as h...

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...

Cost-benefit analysis of universal pool fencing for Texas households with young children

Abstract Background Texas bears a disproportionate burden of pediatric drowning in the United States. Functional pool fencing prevents pediatric drownings, but its economic impact on drowning-related costs remains unclear. We estimated the potential cost savings of implementing a...

Spring Cranioplasty for the Fused Lambdoid and Coronal Sutures: Expanding Indications

Abstract Spring cranioplasty, originally developed for sagittal synostosis, has expanded to address selected lambdoid and coronal deformities by applying continuous mechanical distraction to gradually expand the cranium while avoiding the extensive dissection required for open va...

Development and validation of the arabic version of the Spine Functional Index (SFI-AR) in patients with spinal disorders

Background The Spine Functional Index (SFI) is a patient-reported outcome measure used to evaluate functional limitations in patients with spinal disorders. However, no validated Arabic version has been available, limiting standardized assessment in Arabic-speaking populations. M...

Impact of the COVID-19 Pandemic on Viral Respiratory Testing in Children With Abnormal Urinalysis

OBJECTIVE Respiratory viral panels (RVP) are common, expensive tests that often do not change treatment, especially in children with suspected urinary tract infections. In children with abnormal urinalysis (UA) results, we hypothesize that RVP overuse existed before the COVID-19...

Best-Practice Perioperative Optimization for Craniosynostosis Surgery

Abstract Perioperative optimization in craniosynostosis surgery demands coordinated attention across the preoperative, intraoperative, and postoperative periods, yet considerable practice variation persists across craniofacial centers. Surgical approaches range from minimally inv...

A Rare BCR::SPECC1L::ABL1 Fusion in a Pediatric Chronic Myeloid Leukemia Patient

BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm typically defined by BCR::ABL1 p210 fusions isoforms. OBSERVATIONS: An 8-year-old female CML patient harbored a typical t(9;22)(q34;11) Philadelphia chromosome and BCR::ABL1 fusion by conventional karyoty...

Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals

Abstract Objective To evaluate the management practices of Infantile Epileptic Spasms Syndrome (IESS) across tertiary pediatric hospitals in the United States using a survey‐based approach. Methods A 21‐question survey focused on management setting, work‐up, follow‐up and treatme...

Injury Severity and Near-Absent Helmet Use in NTDB-Eligible Pediatric E-Scooter Trauma: A Single-Center Descriptive Series

Pediatric e-scooter injuries have risen rapidly, yet single-center data describing injury severity, admission patterns, and helmet use within high-acuity trauma populations remain limited. We describe a single-center retrospective series of 31 National Trauma Data Bank (NTDB)–eli...

The Impact of Earthquake-Induced Healthcare Disruption on an Established Developmental Hip Dysplasia Screening Program in an Earthquake Zone

Background/Objectives: Pandemics and natural disasters may delay the diagnosis and treatment of developmental dysplasia of the hip (DDH). In this study, we evaluated the effect of 2023 Kahramanmaraş earthquake-induced healthcare disruption on the DDH screening program. Methods: M...