Technische Universität Dresden

Machine learning algorithms for transplanting accelerometer observations in future satellite gravimetry missions

Abstract Accurate and continuous monitoring of Earth’s gravity field is essential for tracking mass redistribution processes linked to climate variability, hydrological cycles, and geodynamic phenomena. While the GRACE and GRACE Follow-On (GRACE-FO) missions have set the benchmar...

Concurrent Eurasian Heatwaves Will Intensify Beyond the Mean Warming

Abstract Concurrent heatwaves over Europe and North China are the most frequent compound heat extremes across the Northern Hemisphere. They are systematically organized by a recurrent teleconnection along the polar front jet over Eurasia. Using observations and large‐ensemble sim...

Reprocessable Elastomeric Networks Produced via Trimesic Acid‐Induced β‐Hydroxy Ester Crosslinking of Epoxidized Natural Rubber With Tunable Mechanical Properties

ABSTRACT Trimesic acid (TMA) has been employed as a trifunctional crosslinker to develop dynamic epoxidized natural rubber (ENR) networks through zinc‐acetate‐catalyzed formation of β‐hydroxy ester linkages. Unlike conventional sulfur‐vulcanized networks, which are commonly descr...

Determination of alkaline phosphatase inactivation in pasteurised milk under different heat treatment conditions

Raw milk is considered an excellent culture medium for a variety of pathogenic and non-pathogenic microorganisms. The effectiveness of raw milk pasteurisation is verified internationally by measuring residual alkaline phosphatase (ALP) activity. The aim of this study was to evalu...

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Integrated and Decomposition-Based Solution Approaches for Project-Oriented School Timetabling

Abstract This paper investigates the timetabling problem in project-oriented schools and is based on the real-world setting of the Universitätsschule Dresden, an experimental school organized around interdisciplinary project work. In project-oriented schools, traditional subject-...

Binder-conductive additive design for practical sulfurized polyacrylonitrile lithium–sulfur batteries

Abstract Lithium–sulfur batteries are widely regarded as promising next-generation energy storage owing to their high theoretical energy density and the abundance of sulfur. Sulfurized polyacrylonitrile (SPAN) has emerged as a compelling active material, retaining the advantages...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Generalized quasiorders: constructions and characterizations

Abstract Quasiorders $$ \varrho \subseteq A^{2}$$ ϱ ⊆ A 2 have the property that an operation $$f:A^{n}\rightarrow A$$ f : A n → A preserves $$\varrho $$ ϱ if and only if each (unary) translation obtained from f is an endomorphism of $$\varrho $$ ϱ . Generalized quasiorders $$\va...

Design rules for bioorthogonal glycan-based tools

As one of the most abundant and diverse post-translational modifications in biology, glycosylation has a significant influence on the functions of proteins in health and disease. To untangle the complexity of glycan biosynthetic pathways, the process of studying glycosylation has...

Deciphering Dynamic Self‐Healing for Crystallinity Control in β‐Ketoenamine‐Linked Covalent Organic Frameworks

ABSTRACT Covalent organic frameworks derived from triformylphloroglucinol (Tp‐COFs) represent a prominent branch of COFs due to their high potential in separation, energy storage, and optoelectronics. However, the development of Tp‐COFs is often hindered by limited crystallinity,...

Long-term outcomes of balloon dilation of the eustachian tube under local anesthesia

PURPOSE: To evaluate the long-term outcomes, safety, and feasibility of balloon dilation of the Eustachian tube (BDET) performed under local anesthesia in patients with baro-challenge-induced and obstructive Eustachian tube dysfunction (ETD). METHODS: This prospective observation...

The Second Nitrogen Fits: Development of Diazine-Based Macrocyclic Chelators to Stably Bind Radionuclides Used in Targeted Alpha Therapy

Abstract Identifying suitable chelators for 212Pb, 223Ra, and 225Ac and their diagnostic counterparts 131Ba, 133La, and 203Pb remains one of the major challenges in the development of radiopharmaceuticals for targeted alpha therapy. Four novel macrocyclic chelators containing the...

Exciting Objects for Historical Research—Mechanical Gyroscopes in Germany Between 1925 and 1975

ABSTRACT The contribution presents a dissertation project in the history of science and technology that uses gyro instruments as objects of historical research, offering exciting opportunities for investigation using a wide variety of methodological approaches. This paper present...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

4D printing modular twisting metamaterials with reprogrammable functionality and reconfigurable deformation

Developing torsional mechanical metamaterials capable of delivering reconfigurable and adaptive responses through compression-torsion coupling remains a significant challenge. Here, we present a bioinspired multifunctional twisting mechanical metamaterial (MTMM) featuring a modul...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Toward the Rational Design of Molecular Field-Coupled Nanocomputing Candidates

Abstract Molecular Field-Coupled Nanocomputing (MolFCN) is a promising beyond-CMOS paradigm in which information is propagated electrostatically rather than through charge transport, enabling ultra-low-power logic. However, identifying molecules with stable logic states and relia...