Tashkent Pediatric Medical Institute

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Diminished Ovarian Reserve in Advanced Endometriosis: Prevalence, Clinical Predictors, and Patient Awareness of Fertility Preservation

Background & Objective: Advanced endometriosis is recognized as a potential cause of Diminished Ovarian Reserve (DOR), yet data on its prevalence, predictors, and patient awareness in Central Asia are scarce. The present study was conducted with aim to determine the prevalence of...

NRF2‐Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities

ABSTRACT Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron‐dependent form of regulated cell death driven by lipid peroxidation, has emerged...

Time to pacemaker insertion in older adults: A perspective on mortality and functional outcomes

Pacemaker insertion is common in older adults, yet the implications of procedural delays remain unclear. Nguyen and colleagues reported that longer time to implantation was associated with increased mortality over nearly five years. While this contribution is valuable, several me...

Advanced cathode engineering in sodium-ion batteries: doping, phase, and interface modulation from layer oxides to polyanionics

Abstract Sodium-ion batteries (SIBs) have attracted significant attention as viable alternatives to lithium-ion batteries; however, their practical advancement remains limited by cathode-related challenges, including sluggish Na + diffusion, structural degradation, and rapid capa...

Financial Toxicity and Healthcare Inequities among Oncology Patients in Low- and Middle-Income Countries: A Systematic Review

Abstract Financial toxicity represents a major driver of healthcare inequities among oncology patients in low- and middle-income countries (LMICs). This systematic review found that high out-of-pocket healthcare expenditure frequently resulted in catastrophic financial burden, wi...

The impact of climate factors on the risk of mosquito-borne infectious diseases

Climate change and its associated environmental transformations are increasingly recognized as critical drivers of vector-borne disease transmission dynamics. This article provides a comprehensive analysis of how climatic factors – particularly temperature, precipitation, humidit...

CLINICAL EXPERIENCE WITH A FLEXIBLE NYLON OBTURATOR IN A PATIENT WITH AN ACQUIRED MAXILLARY DEFECT

The article presents a clinical case of prosthetic rehabilitation of a 42-year-old female patient with an acquired maxillary defect following surgical treatment of ameloblastoma. A flexible nylon obturator was fabricated to restore the separation between the oral and nasal caviti...

CLINICAL EXPERIENCE WITH A FLEXIBLE NYLON OBTURATOR IN A PATIENT WITH AN ACQUIRED MAXILLARY DEFECT

The article presents a clinical case of prosthetic rehabilitation of a 42-year-old female patient with an acquired maxillary defect following surgical treatment of ameloblastoma. A flexible nylon obturator was fabricated to restore the separation between the oral and nasal caviti...

Design a Novel Recyclable Fe 3 O 4 @SiO 2 ‐TGDM@Ni MICOF Electrode for CO 2 Trap, Electrolyte, and Catalyst for Electro‐Carboxylation Reaction

ABSTRACT The design and development of high‐performance electrocatalytic systems featuring multiple functionalities, excellent recyclability, and reusability constitute a vital and essential advancement in the field of green chemistry. Such innovative approaches significantly mit...

SLEEP AND CIRCADIAN RHYTHMS IN RELATION TO ANDROGEN STATUS IN MIDDLE-AGED MEN: CURRENT EVIDENCE AND CLINICAL IMPLICATIONS

Testosterone secretion in men exhibits pronounced temporal variation and is closely associated with the sleep–wake cycle. Short sleep duration, sleep fragmentation, obstructive sleep apnea, night-shift work, and circadian misalignment are common in modern populations and may inte...

IMPROVEMENT OF THE SURGICAL APPROACH TO THE TREATMENT OF CRANIOVERTEBRAL JUNCTION ANOMALIES ASSOCIATED WITH SPINAL MALFORMATIONS (CLINICAL EXPERIENCE)

Craniovertebral junction (CVJ) anomalies are complex and rare disorders that require precise diagnostic evaluation and individualized treatment strategies. We report a rare case of Arnold–Chiari II malformation with basilar invagination, secondary hydrocephalus, and closed spinal...

IMPROVEMENT OF THE SURGICAL APPROACH TO THE TREATMENT OF CRANIOVERTEBRAL JUNCTION ANOMALIES ASSOCIATED WITH SPINAL MALFORMATIONS (CLINICAL EXPERIENCE)

Craniovertebral junction (CVJ) anomalies are complex and rare disorders that require precise diagnostic evaluation and individualized treatment strategies. We report a rare case of Arnold–Chiari II malformation with basilar invagination, secondary hydrocephalus, and closed spinal...

SLEEP AND CIRCADIAN RHYTHMS IN RELATION TO ANDROGEN STATUS IN MIDDLE-AGED MEN: CURRENT EVIDENCE AND CLINICAL IMPLICATIONS

Testosterone secretion in men exhibits pronounced temporal variation and is closely associated with the sleep–wake cycle. Short sleep duration, sleep fragmentation, obstructive sleep apnea, night-shift work, and circadian misalignment are common in modern populations and may inte...

CLINICAL AND PROGNOSTIC FACTORS OF FUNCTIONAL RECOVERY IN PATIENTS WITH HEMORRHAGIC STROKE

Spontaneous intracerebral hemorrhage (ICH) remains a leading cause of mortality and long-term disability worldwide. Accurate prediction of functional recovery is essential for optimizing treatment and rehabilitation strategies. The objective of this study was to evaluate clinical...

Hepatitis B and D burden in Uzbekistan: comprehensive analysis of seroprevalence and risk correlates from a countrywide study

Abstract Background Uzbekistan faces a substantial burden of hepatitis B and D virus (HBV and HDV) infections despite implementing universal hepatitis B vaccination in 1998. Regional variation in disease distribution and contemporary transmission dynamics remain inadequately char...

The Transformation of the Microenvironment: From Observer to Coordinator in Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma Development

ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is a common asymptomatic plasma cell disorder and the major precursor state of multiple myeloma (MM). Although progression is partly shaped by intrinsic genetic and epigenetic changes within the plasma cell clone,...

Experimental and thermal performance evaluation of a PCM-enhanced solar water heater with a spiral coil heat exchanger

Latent heat thermal energy storage is an effective approach for enhancing the performance of solar water heating (SWH) systems by storing surplus thermal energy and delivering it during periods of low solar availability. In this study, the thermal performance of a solar water hea...