Tarbiat Modares University

α-Santonin from a marine sponge exhibits anticancer activity and mechanistic effects in colorectal cancer

Colorectal cancer (CRC) requires new therapeutic agents with minimal systemic toxicity. Marine-derived natural products represent a promising source of drug candidates because of their unique bioactivity. This study evaluated the anti-tumor potential and possible molecular mechan...

Immunogenicity assay of an experimental inactivated vaccine against bovine parainfluenza virus type 3 in calves

Abstract Background Bovine parainfluenza virus type 3 (BPIV3) is a key pathogen in the bovine respiratory disease complex (BRD). This study aimed to develop an effective inactivated vaccine using an indigenous Iranian BPIV3 strain, evaluating different inactivation methods and ad...

Neuroprotective potential of linagliptin against mancozeb induced neurotoxicity

Abstract Background The research investigates the neuroprotective effects of Linagliptin (Lina), a dipeptidyl peptidase-4, against the neurotoxic impacts of Mancozeb (MNZ), which is known to cause cognitive deficits and oxidative stress. Methods: The study involved six groups of...

Rational Assembly of Multifunctional Fe/Mn MOF through Mixed-Linker and Defect Engineering for CO2 Cycloaddition Reaction

Abstract The development of heterogeneous catalysts that cooperatively integrate multiple active sites within a defined architecture is critical for complex reactions such as the cycloaddition of CO2 to epoxides. Herein, a rational design strategy for constructing a defect-engine...

The effect of acute respiratory alkalosis on anaerobic performance: a systematic review

High-intensity short-duration exercise relies predominantly on anaerobic metabolism, leading to rapid accumulation of hydrogen ions and metabolic acidosis, which impairs muscle function and performance. Acute respiratory alkalosis induced by voluntary hyperventilation (VH) has be...

Synthesis of Conical SiC Nanowhiskers From Hybrid Electrospun PVA / SiO 2 / MWCNT Nanofibers

ABSTRACT In this work, one‐dimensional silicon carbide (SiC) nanowhiskers (NWs) were successfully synthesized via catalyst‐free carbothermal reduction of electrospun hybrid nanofibers composed of polyvinyl alcohol, silica, and multi‐walled carbon nanotubes (MWCNTs). The morpholog...

Integrated Hydrogeochemical Characterization, Drinking Water Quality Assessment, and Spatial Analysis of Groundwater Using GIS and Multivariate Statistics: A Case Study of Fars Province, Iran

Groundwater quality in semi-arid regions is influenced by interacting geological, climatic, and human factors. This study integrated hydrochemical analysis, ionic relationships, multivariate statistics, Water Quality Index (WQI), and GIS-based spatial analysis to evaluate groundw...

Tourism as soft power: a configurational analysis of nation branding in constrained geopolitical contexts

Purpose This study investigates how tourism functions as a soft power mechanism amid geopolitical constraints, examining the configurational conditions under which tourism practices enhance nation branding effectiveness (NBET). Focusing on Iran as an illustrative transitional cas...

Direct and prey-mediated vitamin supplementation reshape predator–prey dynamics in Amblyseius swirskii (Acari: Phytoseiidae)

Abstract Micronutrient supplementation has been proposed as a strategy to improve factitious diets for predatory mites, yet the influence of nutrient delivery routes on predator performance remains poorly understood. We evaluated the demographic responses of Amblyseius swirskii (...

Risk-integrated performance budgeting in insurance: a systems framework for strategic resource allocation under regulatory constraints

Purpose Financial services organizations face increasing pressure to optimize resource allocation while managing complex regulatory requirements and stakeholder expectations. Traditional budgeting approaches prove inadequate for organizations operating with temporal revenue-cost...

Implementation challenges and unintended financial consequences of e-prescribing in an integrated payer–provider health system: a qualitative study from Tehran, Iran

Abstract Background Electronic prescribing (e-prescribing) is increasingly used to improve the efficiency, safety, and continuity of healthcare. However, implementation challenges may produce unintended consequences, particularly in health systems where a single organisation comb...

Design and validation of the love in nursing instrument

Abstract Existing instruments designed to measure the construct of love exhibit various limitations or fail to specifically address love within the nursing context. Consequently, there is a distinct lack of a unified, domain-specific tool to evaluate love in the nursing professio...

Beyond linearity: conjunctural dynamics of sustainability-oriented policy innovation in coastal tourism governance

Purpose This study advances beyond linear models by developing a contextually grounded configurational framework with clearly defined scope conditions, limiting its applicability to coastal tourism destinations experiencing complex socio-political and environmental change. It exp...

Explaining the relationship between urban land use per capita and residents’ perceived accessibility using a spatial justice approach: A case study of Tehran metropolis

Land use per capita remains one of the most widely used quantitative indicators in urban planning for evaluating the provision of urban services. Despite its normative significance, its validity as a proxy for accessibility has received limited empirical examination. This study i...

Synthesis of SAPO-34 using polyacrylamide enhances the catalyst lifetime and selectivity of light olefins in MTO

The industry is under increasing pressure to develop economically and environmentally feasible manufacturing pathways for light olefins, driven by growing global demand from rising consumption and emerging economies. In this context,, the Methanol-to-Olefins (MTO) process stands...

Nonlinear hydrological responses to intermediate development pathways in semi-arid watersheds

Hydrological vulnerability in semi-arid watersheds is increasingly shaped by coupled climate and land-use change, yet the relative importance of runoff and sediment dynamics remains unclear. Here, we develop an integrated socio-hydrological framework that combines SWAT modeling,...

Indeterminate Propositions and the Emergence of Truth in the Ikhwān al-Ṣafāʾ’s Theory of Quantifiers ( Sūr )

This article argues that the Ikhwān al-Ṣafāʾ introduce a distinctive technical and normative innovation into tenth-century Islamic logic through their account of sūr: truth and falsity become manifest only when a statement is sufficiently closed against interpretation, by quantif...

Modified Strain Gradient–Based Finite-Element Approach for the Analysis of Size-Dependent Higher-Order Microshells

Abstract This study developed a comprehensive framework for size-dependent higher-order microshells by incorporating the modified strain gradient continuum theory (MSGT). The microshell formulations integrate higher-order kinematics and explicitly account for size-reduction effec...

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

Entrepreneurial enablers of agile digital transformation in Iranian SMEs: a hybraid Delphi–BWM approach

Purpose Agile digital transformation (ADT) is essential for small- and medium-sized enterprise (SME) competitiveness, particularly in emerging economies facing institutional fragility. In Iran, sanctions, limited access to advanced technologies and market volatility intensify the...