Tarbiat Modares University

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

Entrepreneurial enablers of agile digital transformation in Iranian SMEs: a hybraid Delphi–BWM approach

Purpose Agile digital transformation (ADT) is essential for small- and medium-sized enterprise (SME) competitiveness, particularly in emerging economies facing institutional fragility. In Iran, sanctions, limited access to advanced technologies and market volatility intensify the...

The janus-faced function of mesenchymal stem cells in oral cancer

Mesenchymal stem cells (MSCs), which exist in bone marrow, tooth pulp, and tumor microenvironments, have a dual role in oral malignancies. These cells interact closely with cancer stem cells (CSCs) and the tumor microenvironment (TME). On the one hand, MSCs accelerate the growth...

AI-driven design and electrothermal actuation of 4D-Printed carbon fiber-reinforced composites

This study presents a data-driven framework for the design, prediction, and optimization of electrothermally actuated composite structures based on continuous carbon-fiber reinforced shape memory polymers (CCF-SMPs). A Multiphysics model was developed and calibrated against exper...

Formulation and characterization of ginsenoside Rh2-loaded casein nanoparticles for enhanced radioprotection

Ionizing radiation poses a significant threat to human health and necessitates the development of effective radioprotective agents. In this study, the radioprotective efficacy of ginsenoside Rh2-loaded casein nanoparticles (Rh2-CNPs) was synthesized and evaluated. The Rh2-CNPs we...

Plasma p-tau217 as a two-cutoff approach to improve tau-PET screening and trial recruitment in Alzheimer’s disease

Abstract Blood-based biomarkers could broaden access to Alzheimer’s disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau PET using a harmonized ADNI baseline cohort and an inde...

A comprehensive look at Respiratory Syncytial Virus (RSV): from pathogenesis to prevention

Respiratory Syncytial Virus (RSV) is a formidable respiratory pathogen that particularly affects infants and children. RSV presents with diverse clinical severity, most often causing mild upper airway symptoms but sometimes progressing to severe and potentially fatal lower respir...

Contrasting Soil Chemical and Microbial Responses to Moderate Thinning in a South Swedish Spruce Forest

Abstract Small-scale forest owners frequently implement thinning to enhance stand productivity, improve timber quality, and maintain structural diversity; however, its short-term effects on soil physicochemical and biological properties remain insufficiently understood. This stud...

Tissue-specific transcriptome analysis uncovers phenylpropanoid biosynthetic genes in Althaea officinalis

Althaea officinalis is a medicinal plant, rich in mucilage and polyphenols and traditionally used to relieve inflammation and irritation of respiratory, digestive, and urinary tissues. This study presents the first comprehensive transcriptomic analysis of A. officinalis revealing...

Agricultural interventions in developing-region smallholder systems: A harmonized outcome–metric meta-analysis of productivity, livelihood, and welfare outcomes

Agricultural interventions are central to smallholder productivity, livelihoods, and food-security policy in developing regions, but their evidence base is fragmented across outcomes, effect metrics, designs, and contexts. This study provides a quality-controlled, harmonized outc...

Simultaneous suppression of Polyphagotarsonemus latus and Tetranychus urticae by Neoseiulus californicus on greenhouse pepper

Greenhouse pepper is frequently attacked by two economically important mites: the broad mite Polyphagotarsonemus latus (Banks) (Acari: Tarsonemidae) and the two-spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae). The release of the predatory mite Neoseiulus calif...

Geochemical and Isotopic Constraints on the Origin of the Early Palaeozoic Chah‐Nar Pb–Zn Deposit, Sanandaj–Sirjan Zone (Iran)

ABSTRACT The Chah‐Nar Pb–Zn deposit in the southern Sanandaj–Sirjan Zone, Iran, represents Early Palaeozoic stratiform sulfide mineralization hosted by organic‐rich volcano‐sedimentary rocks deposited in a Proto‐Tethyan back‐arc basin. Despite the occurrence of stratiform Pb–Zn m...

Optimizing the radiolytic degradation of aspirin and acetaminophen in aqueous solutions using a Rhodotron electron-beam accelerator and central composite design

The escalating pollution of limited freshwater resources by ECs represents a critical byproduct of modern industrialization. Pharmaceutical compounds, specifically NSAIDs like ACM and ASP, are frequently detected in aquatic environments because conventional wastewater treatment p...

Correlation of Epstein–Barr virus (EBV) expressed miRNAs (BART4, BART7, and BHRF1) with chronic lymphocytic leukemia stages

Epstein-Barr virus (EBV) has been shown to play a role in the pathogenesis of several B-cell malignancies, but its role in chronic lymphocytic leukemia (CLL) remains unclear. EBV-encoded microRNAs, including BHRF1 and BART families, are thought to modulate host cell survival and...