Tanta University

Role of drug induced sleep endoscopy in morphological diagnosis with continuous positive airway pressure titration in OSA patients

Abstract Background Continuous positive airway pressure (CPAP) is the most extremely effective treatment for moderate-to-severe OSA. Though, upper airway (UAW) obstruction location identification is a difficult task in order to comprehend the potential mechanism of a high CPAP ti...

Ethnopharmacological insights into type 2 diabetes management by traditional Moroccan herbal teas: HPLC-MS characterization of phenolic compounds and their related antioxidant and enzyme inhibitory activities

Abstract Background Traditional Moroccan herbal teas are widely consumed and have been traditionally used for managing chronic metabolic disorders, particularly type 2 diabetes mellitus (T2DM). Although these preparations have a long history of ethnomedicinal use, their phenolic...

A Sustainable, Quality‐by‐Design (QbD) Inspired Spectrofluorimetric Method for the Concurrent Analysis of Cetirizine and Montelukast in COVID‐19 and Allergic Rhinitis Combination Therapy

ABSTRACT A novel direct spectrofluorimetric method was developed and validated for simultaneous determination of cetirizine hydrochloride (CTZ) and montelukast sodium (MKT), commonly used in COVID‐19 combination therapy. Montelukast was determined using first derivative synchrono...

Biomass‐Derived Carbon Dots–Based FRAP Analog for Sensitive Evaluation of Antioxidant Activity: Application to Pharmaceutical Products and Plant Extracts

ABSTRACT Ferric reducing antioxidant power (FRAP) is a well‐established antioxidant in vitro assay. This work introduces an innovative FRAP‐analog assay based on green‐synthesized carbon dots (GCDs) for the sensitive evaluation of antioxidant activity. The GCDs were prepared via...

Severe, delayed-onset thrombocytopenia after prolonged chlorothiazide use in a former preterm infant with bronchopulmonary dysplasia: a case report

Abstract Introduction Drug-induced immune thrombocytopenia (DITP) is a rare, antibody-mediated adverse effect that typically occurs within days to weeks of drug exposure and is rarely reported in infants receiving prolonged diuretic therapy. Case presentation We report a former 2...

Algorithm-based approach to the management of rhino-maxillary mucormycosis: part II of a two-part study

Rhino-maxillary mucormycosis (RMM) is an aggressive, life-threatening fungal infection associated with substantial morbidity and mortality. While early diagnosis is universally advocated, robust quantitative evidence delineating how defined diagnostic delays influence objective c...

Coupled numerical and explainable machine-learning assessment of cracked diaphragm walls in anisotropic earth dams

Abstract This study evaluates how diaphragm-wall cracking and hydraulic anisotropy jointly affect seepage discharge and downstream slope stability in earth dams. A coupled two-dimensional numerical framework was developed by transferring pore-water pressures obtained from steady-...

Efficacy of early blood purification on serum inflammatory mediators in severe acute pancreatitis: a systematic review and meta-analysis

Severe acute pancreatitis (SAP) is the most critical form of acute pancreatitis (AP), characterized by a dysregulated systemic inflammatory response that drives early organ failure and mortality. Current management remains mainly supportive. Early blood purification (EBP) has bee...

Efficacy and safety of oncolytic herpes simplex virus therapy in solid tumors: a systematic review and meta-analysis of 38 clinical trials

Abstract Background Oncolytic herpes simplex virus (oHSV) therapy represents a novel immunotherapeutic approach for solid tumors. Despite regulatory approval of talimogene laherparepvec (T-VEC) for advanced melanoma, comprehensive pooled estimates of efficacy and safety across di...

Is methylphenidate truly cardiac-safe? Insight from biventricular speckle tracking echocardiography in pediatric patients with attention deficit hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition identified by inattention, hyperactivity, and impulsivity. ADHD pharmacotherapy, particularly methylphenidate (MPH), has raised concerns about its cardiovascular safety. We aimed to assess th...

Diagnostic performance of T2 mapping and diffusion-weighted MRI in early detection of cartilage degeneration in knee osteoarthritis

Abstract Background Early knee osteoarthritis (OA) is associated with biochemical cartilage changes that may not be visible on conventional magnetic resonance imaging (MRI) or plain radiography. Quantitative MRI techniques, including T2 mapping and diffusion-weighted imaging (DWI...

Knowledge, attitudes, and practices (KAP) toward stroke prevention among hypertensive patients in Egypt: a multicenter cross-sectional study

Abstract Stroke is the second most common cause of death worldwide and represents a major health concern in Egypt. Hypertension is the most important modifiable risk factor for stroke; we aim to assess knowledge, attitudes, and practices (KAP) toward stroke prevention among hyper...

Complications and Safety Profile of XEN ® Gel Stent in Glaucoma: A Five-Year MAUDE Database Analysis

Purpose To analyze adverse events associated with the XEN® Gel Stent using the FDA’s Manufacturer and User Facility Device Experience (MAUDE) database.Methods The FDA MAUDE database was queried for reports from January 1, 2020, to November 8, 2024, using the product code “KYF.” R...

Ensemble-based feature selection and classification for ischemic stroke subtyping

Abstract Strokes have become a major cause of death in recent years due to their effects on the central nervous system. Hemorrhagic and ischemic strokes (IS) are the two most types that severely harm the central nervous system. Subtyping ischemic stroke is crucial for both the pr...

Numerical analyses into carbon circularity through integrated biomass gasification and electrochemical CO2 conversion to formic acid

The present study proposes an integrated gasification-electrochemical CO 2 reduction system for the co-production of syngas and formic acid, hence, reducing CO 2 emissions and promoting carbon circularity. Unlike the conventional gasification systems which focus primarily on syng...

Geopolitical risks and value chain costs in Egypt and Saudi Arabia’s milling industry: the moderating effect of supply chain structure

Abstract This study empirically investigates how heightened geopolitical risks affect the value chain costs of upstream and downstream activities in Egyptian and Saudi milling firms from 2020 to 2025, and the moderating effect of supply chain structure. Grounded in resource depen...

Axial compressive behavior of wavy-shaped micropiles in sandy soils: an experimental investigation

Conventional micropiles generally depend on shaft resistance; however, their capacity may be limited, motivating improved geometries to enhance axial performance. This research investigates the enhancement of novel wavy-formed micropiles relative to standard micropiles under axia...

A study of vestibular function in children with learning disabilities

Abstract Background Specific Learning Disabilities (SLD) are a group of neurodevelopmental disorders that can significantly hamper a person’s ability to acquire new knowledge. Objective: to diagnose the existence of vestibular dysfunction in children with SLD as an underlying hid...

Epigenetic Regulation of Host Immunity During Parasitic Infections: Mechanisms, Immune Evasion, and Therapeutic Opportunities

INTRODUCTION: Parasitic infections remain a major global health challenge involving complex interactions between pathogens and host immunity. Emerging evidence indicates that epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-co...

Clinical presentation, management, and maternal-fetal outcomes in gestational hemangioblastoma: a systematic review of case reports and case series

Hemangioblastoma is a highly vascular benign tumor of the central nervous system. Its presentation during pregnancy poses diagnostic and management challenges, while the evidence base consists largely of case reports and small case series. We aimed to describe the clinical presen...