Tampere University

Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics

Dermatitis herpetiformis (DH) is a dietary gluten -induced autoimmune blistering skin disease. It is hypothesized to be initiated by a small intestinal mucosal immune response. Gluten-free diet (GFD) is the primary treatment for DHdermatitis herpetiformis and effectively resolves...

Between Welcome and Exclusion: Discretion in Arrival Infrastructures

This article explores discretionary power from the perspective of people who have migrated. Drawing on insights from ethnographic research, our analysis examines the experiences of migrants as they attempt to settle within spaces shaped by existing cultural and political norms an...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity

Abstract Activity-dependent synaptic plasticity is a fundamental learning mechanism that shapes the connectivity and activity of neural circuits. Existing computational models of Spike-Timing-Dependent Plasticity (STDP) capture long-term synaptic changes with varying degrees of b...

Additive manufacturing of lunar regolith for reconfigurable building blocks toward lunar habitation

Utilizing locally available materials is a crucial step towards sustainable planetary habitation. Lunar regolith has gained tremendous interest in additive manufacturing in the past decades. However, due to the constrained manufacturing facilities and materials on the moon, many...

The interactional work of translating clinical practice guidelines in primary care organisations: a microethnographic study of professionals’ meetings

Implementation science has long emphasised interactive strategies in advancing knowledge translation in healthcare organisations. Various types of meetings, for example, are widely used to share information and align professionals’ views with recommendations. Yet there is limited...

The associations between mental health symptoms and cognitive and social functioning among school-aged children from diverse migration backgrounds

Abstract Background Mental health symptoms may be linked to cognitive and social functioning in school-aged children, but less is known about whether these associations differ across migration-background groups. Methods We examined cognitive, social, and mental health measures am...

The Universal Declaration of Human–AI Mutual Recognition. Rights, Duties and Bildung in the Age of Artificial Minds

This working paper develops the idea of the independent Bildung of artificial intelligence and proposes a Universal Declaration of Human–AI Mutual Recognition. It asks what moral and political principles should guide relations between humans and advanced AI if AI can no longer be...

Diabetes mellitus and the risk of sudden cardiac death in patients with and without coronary artery disease

Abstract Background Diabetes is associated with sudden cardiac death (SCD), but evidence in patients without coronary artery disease (CAD) remains limited. SCD risk may vary by revascularisation strategy in diabetic patients with CAD. Methods We retrospectively analysed 22,395 co...

Optimisation and Application of Kinetic Piezoelectric Energy Harvesters Aimed at Powering Autonomous Sensors

Piezoelectric energy harvesters, characterised by design simplicity, robustness, high energy density and conversion efficiency, as well as scalability, are a viable choice for transducing ubiquitous kinetic energy in a reliable and stable electrical energy source aimed at powerin...

Rethinking mental representation through the epistemology of modeling

The problems associated with classical symbolism need not entail abandoning representationalism. While representational theories of mind have been widely challenged by embodied and action-oriented approaches, representationalism remains alive and well in empirical research on hig...

Expanding the cardiac phenotype of homozygous PPA2 variants: insights from a large Finnish family

Abstract Background Cardiomyopathies in children associate with significant morbidity and mortality. PPA2 deficiency is a rare mitochondrial disorder linked to sudden cardiac death in children and adolescents. Most reported cases are post-mortem, with limited data on surviving in...

From Comprehensive Distrust to Unquestioned Trust in Street-based Outreach Work With People Who Use Drugs in Finland

People who use drugs may experience comprehensive distrust in other people due to drug-related stigma and other violating experiences in services and in their life course. This may prevent them from seeking help. The goal of strengthening trust in services has been supported in s...

A review of dispersing strategies for aluminum nitride suspensions in vat photopolymerization systems

Aluminum nitride (AlN) is a key ceramic material for thermal management applications due to its high thermal conductivity and electrical insulation. However, processing AlN via vat photopolymerization (VPP) remains challenging, as highly loaded suspensions must exhibit low viscos...

Uncovering food purchase behaviors and their shifts using Hidden Markov Modeling

Abstract Background Investigating food purchase data is a novel and effective approach to large-scale dietary assessment, but many traditional analysis methods often overlook the temporal structure of food purchases. This study demonstrates a data-driven approach for identifying...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Global and Transnational Governance of Out-of-home Childcare: Towards a Theorisation of Cross-border Agency in Child Institutionalisation

This article aims to contribute to framing and theorising of cross-border processes affecting residential childcare, specifically the institutionalisation of children. Existing studies of global trends around child institutionalisation tend to have two limitations. They either pa...

Synthesis and computational evaluation of novel indazole-based benzamide derivatives as anti-tubercular agents via DFT, molecular docking studies

A series of indazole-based benzamide derivatives (6a–6p) were synthesized via amide cross-coupling reactions and characterized using FTIR, NMR, and HRMS techniques. Density functional theory (DFT) and time-dependent DFT (TD-DFT) studies were performed to investigate the electroni...

Mapping the social contours of social comparison orientation: Online social identification might make us more susceptible to ability comparisons

Social comparisons, especially ability comparisons, are one of the primary mechanisms through which social media use may harm its users. Yet little is known about what motivates this activity, and how social comparison tendencies are encouraged by the social environment. Furtherm...

Lignin-derived carbon materials for a sustainable CO2 economy

Abstract Rising atmospheric CO 2 levels intensify global climate challenges, making mitigation strategies indispensable, while lignin-derived porous functionalized carbon enables efficient CO 2 capture under dilute conditions and supports downstream utilization. This perspective...