Tampere University

Carbonic Anhydrases in Mycobacteria: Linking Metabolic Adaptation to Phenotypic Drug Tolerance

Abstract Tuberculosis (TB) treatment is increasingly challenged by both antimicrobial resistance (AMR) and phenotypic drug tolerance, the latter representing a reversible physiological state that contributes to persistence and prolonged therapy. While AMR is driven by heritable g...

SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis

Abstract Purpose Primary salivary gland tumors form a heterogeneous group with diagnostic challenges. Sex-determining region Y-related homeobox 10 (SOX10) is a transcription factor studied in primary salivary gland tumors for over a decade. To date, no systematic review or meta-a...

A comparative study of physically activated biochars with multiple aqueous binders for sustainable supercapacitors

Electric double-layer capacitors were fabricated using CO 2 -activated carbons derived from three biochar precursors, two industrial Finnish biochars and an in-house willow biochar, combined with water-based chitosan and styrene-butadiene rubber/carboxymethyl cellulose binders. T...

Computational Study of Gas-Phase Reactions to Produce Sulfite Esters: A New Class of Sulfur Containing Molecules in the Atmosphere?

Abstract We use computational quantum chemistry to study gas-phase reactions of aldehydes with water and sulfur dioxide. We find that a new reaction leading to the formation of previously nearly unstudied sulfite esters is possible with a comparatively low barrier. The reaction c...

Parents’ Grief Process After the Death of Their Child From Substance Abuse

The purpose of this study was to describe parents’ grief process after the death of their child caused by substance abuse. The research data were collected from parents at closed peer discussion forums online using an e-questionnaire with open-ended questions (n = 95) and seven p...

‘Pushing the crisis button’? Temporal space and institutional synchronization in Finland's COVID-19 governance

The article examines how the temporal space of a crisis is constructed, synchronized and contested within crisis governance. Drawing on conceptual history and recent scholarship on crisis temporalities, we introduce the concept of ‘institutional synchronization’ to capture the ac...

When the doctor believes you, but you’re still not happy: Legitimized contested illness and patients’ negative post-consultation experiences and agency

This article investigates patients’ negative and ambivalent lived post-consultation experiences and the related agencies when a doctor legitimizes their contested illness. The primary data consist of 25 telephone interviews conducted soon after the patients’ consultation with a d...

Digital communication and occupational well-being in 25 European countries

Abstract This paper examines the association between digital communication at work and employee well-being, moderated by occupational status and the fulfillment of basic psychological needs. Two studies were conducted to investigate these relationships. Study 1 utilized data from...

Inequalities in sustainable ageing: functional mobility and depressive symptoms across migration subgroups among Russian-speaking migrants in Finland

Abstract Sustainable ageing depends on equitable opportunities to maintain physical, mental, and social well-being, yet older migrants are often treated as a homogeneous group. This study aimed to identify sociodemographic and migration-related subgroups among midlife and older R...

Catching the spark: The role of electrodermal activity in understanding teacher enthusiasm and students' lesson enjoyment

Abstract Process‐oriented approaches are needed to understand the temporality and dynamics of teacher–student interactions in higher education classrooms. In this study, we follow a complexity science approach, based on non‐linear intra‐ and inter‐personal physiology methods, to...

Who perceives access? Disparities in satisfaction with public transport availability and associations with perceived accessibility in the Netherlands

Accessible public transport is important for meeting daily mobility needs and supporting activity participation, particularly among vulnerable groups. Understanding how different population groups perceive access to public transport is critical in addressing transport-related soc...

Automating clinical information retrieval from Finnish electronic health records using large language models

Abstract Clinicians often need to search for patient-specific information within electronic health records (EHRs) containing years of heterogeneous longitudinal documentation, a task that can be time-consuming, cognitively demanding, and prone to oversight. We evaluated 14 locall...

Linking acute exposure to future risk: an omics-to-AOP new approach method for next-generation risk assessment in a human in vitro lung air–liquid interface model

New approach methodologies (NAMs) are transforming chemical safety assessment by shifting focus from apical toxicity endpoints toward mechanistic, human-relevant prediction of adverse outcomes. Here, we present a human lung air-liquid interface (ALI) alveolar epithelial model cou...

Using Formal and Computational Modelling to Develop an Initial Within-Person System Dynamics Model of Relapse in Smoking Cessation: A Participatory, Iterative, Multi-Method Approach

Popular relapse prevention theories are represented using natural language descriptions and lack temporal information about how phenomena of interest (i.e., ‘relapse’, ‘prolapse’, ‘abstinence’) are dynamically caused over time and within individuals. We drew on the Theory Constru...

The degree of knowledge gain metric: Evaluating how searchers acquire new information while searching online

This study presents the degree of knowledge gain, a behavioral metric that estimates how much searchers learn during Web searches. Grounded in information theory and Shannon entropy, the metric quantifies reductions in uncertainty by analyzing query reformulations, clicks, and do...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Microbial differences and continuity across rectal, vaginal and endometrial sites in obese and normal-weight infertile women

Abstract Background This study characterizes microbial relationships and bacterial transfer across the rectal, vaginal and endometrial microbiomes upon embryo transfer, and evaluates the influence of obesity on site-specific profiles. The Tampere Infertility Microbiome Project (T...

Sticky edtech: enacting postdigital platform realities in lower secondary schools

This article addresses the micropolitics of platformisation by exploring the affective dynamics between students, devices, and digital platforms in two lower secondary schools in the Nordic countries. Platformisation is at the core of contemporary edtech, constituting a central p...

Basic Psychological Needs and Motivational Constructs Behind Behavioral Intention Toward Hypothetical Technology-Based Solutions for Loneliness

Abstract Today, loneliness is a widely recognized health concern. Technology offers growing opportunities to develop solutions for mental health challenges. To design effective solutions, this study aims to understand the psychological and motivational factors that influence pote...

Beyond the V-PCC Reference Model: A Holistic Approach to Low-Complexity Attribute Map Generation

Video-based Point Cloud Compression (V-PCC) efficiently compresses dynamic point clouds by projecting 3D patches into 2D occupancy, geometry, and attribute maps before video encoding. The reference attribute map generation pipeline relies on assumptions inherited from the standar...