Tabriz University of Medical Sciences

An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors

Abstract Background Acute heart failure (AHF) is a significant cardiovascular syndrome characterized by either new-onset heart failure (HF) or acutely decompensated heart failure (ADHF), typically presenting with systemic and pulmonary congestion. The European Society of Cardiolo...

Ultra-processed food consumption (NOVA index) and the odds of diabetic nephropathy in women: a case-control study

diabetic nephropathy (DN) is a major complication of diabetes mellitus associated with increased morbidity and mortality. Dietary factors, particularly unhealthy food consumption, may contribute to kidney dysfunction. This study aimed to investigate the association between the NO...

Automated lung tumor segmentation using enhanced U-Net architectures: a multi-backbone comparative study for clinical applications

Lung cancer remains a leading cause of cancer-related mortality worldwide, and manual delineation of tumors on computed tomography (CT) is time-consuming and prone to inter-observer variability. This study systematically evaluates nine deep learning configurations for automated l...

Bacterial Outer Membrane Vesicles in Colorectal Cancer: Interdomain Communication Hubs in Pathogenesis and Immunotherapy

The complex interaction between the intestinal microbiota and host mucosal immunity plays a defining role in colorectal cancer (CRC) development and therapeutic outcomes. Recently, bacterial outer membrane vesicles (OMVs)—nano-sized, lipid-bilayered extracellular particulates rel...

From Taboo to Resilience: Redefining Children’s Concept of Death to Mitigate Future Anxiety

Death, despite its universality, remains a taboo subject in many families and educational settings. Avoidance is often driven by a desire to protect children from emotional distress, yet evidence suggests that protective silence fosters latent anxiety. Developmental psychology de...

Green-Synthesized Mesoporous Silica-Enhanced Herbal Nanofibers with Antimicrobial, Anti-Inflammatory, and Biocompatible Wound Healing Potential

Advanced wound dressings should actively promote tissue repair while preventing microbial infection and excessive inflammation. In this study, multifunctional electrospun nanofibers composed of poly(vinyl alcohol)/chitosan/gelatin were developed by incorporating green-synthesized...

Association between serum uric acid levels and the lipid accumulation product index among the University of Medical Sciences employees of the Azar cohort study

Elevated serum uric acid (SUA) levels (hyperuricemia (HUA)) contribute to the development and progression of metabolic disorders. Growing evidence links HUA to adverse lipid profiles and adiposity indices. The Lipid Accumulation Product (LAP) index is a reliable indicator that be...

Incremental Prognostic Value of CT Indices Derived from Midline Shift and Hematoma Thickness in Acute Subdural Hematoma

Background: In acute subdural hematoma (ASDH), early risk stratification relies heavily on hematoma thickness (HT) and midline shift (MLS). Composite indices derived from these measures have been proposed to better characterize mass effect, but their incremental prognostic value...

Low-level laser irradiation stimulated tumoricidal impacts and dose-dependent modulation of Wnt signaling in three-dimensional human colorectal cancer microspheres

The high incidence of colorectal cancer (CRC) has been a big challenge in human medicine. Along with several available therapies, specific modalities, e.g., low-level laser irradiation (LLLI), have been introduced to achieve proper regenerative outcomes. Unfortunately, most studi...

Long-term exposure of Lactobacillus rhamnosus to quercetin enhances its anti-angiogenic and anti-colorectal cancer efficacy

Abstract Colorectal cancer (CRC) is the second leading cause of cancer death worldwide, with rising incidence projected over the coming decades. Here we show that prolonged exposure of Lactobacillus rhamnosus PTCC 1637 to quercetin (up to 200 µg/mL) improves its probiotic traits...

Comparison of adding magnesium sulfate versus dexmedetomidine to intrathecal bupivacaine in patients undergoing total knee arthroplasty: a randomized double-blind clinical trial

Total knee arthroplasty is frequently associated with substantial postoperative pain, and spinal anesthesia with intrathecal bupivacaine is commonly used to provide effective perioperative analgesia. Adjuvants such as magnesium sulfate and dexmedetomidine may enhance block qualit...

A pathway model of the predictors of professional psychological help-seeking intentions in adults

Abstract Objective Many people who have suicidal thoughts or engage in related behaviors do not seek help from mental health professionals. The reasons for this are complex and have not been well-studied in our society. Therefore, this study aimed to investigate variables related...

Developing a policy brief to promote vaginal delivery in Iran

Cesarean section is one of the most common surgeries in the world and a worrying challenge for women’s health in developed and developing countries. According to the World Health Report, natural childbirth is an important indicator in improving the health of mothers. Therefore, p...

A 7-year-old boy with cerebral vein thrombosis in favor of multisystem inflammatory syndrome: a case report

Abstract Background The term “multisystem inflammatory syndrome in children” has been known since the beginning of the coronavirus pandemic and refers to systemic inflammation with multisystem involvement. Neurological damage in patients with MISC in various clinical forms has be...

Rational design of short hybrid Cecropin B/Aurein 1.2 peptide analogues: in vitro synergistic anti-MRSA and anti-biofilm activities

Abstract Background The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and the limited efficacy of conventional antibiotics necessitate the development of novel antimicrobial agents. This study aimed to design short hybrid antimicrobial peptides deriv...

Personalized nanovaccines from tumor cells: reshaping the microenvironment and defeating heterogeneity

Tumor heterogeneity and an immunosuppressive microenvironment are major obstacles to effective cancer immunotherapy. Personalized nanovaccines derived from autologous tumor cells offer a compelling strategy to overcome these challenges by preserving the full spectrum of patient-s...

Artificial intelligence and radiogenomics in the peritumoral microenvironment of gliomas: a systematic review of diagnostic performance and clinical implications

Introduction Delineating infiltrative peritumoral edema (PTE) in gliomas remains challenging due to acquisition variability and the lack of histopathological validation. We systematically assessed artificial intelligence (AI) and radiomics models for peritumoral characterization....

Prevention strategies for catheter-associated urinary tract infections (CAUTIs): a best practice implementation project.

BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are among the most common health care-associated infections, contributing to increased morbidity, prolonged hospital stays, and elevated health care costs. However, despite established prevention guidelines, compli...

Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception

Metastasis remains the leading cause of cancer-related mortality, yet the metastatic cascade is initiated long before circulating tumor cells reach distant organs. Central to this early phase is the premetastatic niche (PMN), a dynamic and tumor-conditioned microenvironment in wh...

Spectrophotometric recognition of tramadol using toluidine blue as acidophilic metachromatic optical probe

Tramadol (TRD), a centrally acting analgesic of significant clinical importance due to its opioid nature, necessitates precise monitoring of its levels in the body to ensure therapeutic efficacy and prevent potential toxicity. This research, aimed at overcoming the challenges of...