Suzhou Institute of Biomedical Engineering and Technology

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

ABSTRACT Circulating tumor cells (CTCs), as pivotal targets in liquid biopsy, offer dynamic, multidimensional insights into tumor heterogeneity and metastatic progression. However, their extreme rarity, pronounced heterogeneity, and the complexity of the blood microenvironment se...

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Multi-mode droplet splitting on active-matrix digital microfluidics: quantitative boundaries and optimal sequential generation

Precise generation of microdroplets at picoliters to microliters scale is critical for advancing microfluidics technologies and precision life sciences research. Digital microfluidics enables programable individual droplet, however, there still lacks comprehensive characterizatio...

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...

Highly Sensitive Electrochemical Biosensing Strategy Based on Multiple CRISPR/Cas12a Trans -Cleavage Units

Abstract This study presents the assembly of multiple CRISPR/Cas12a units by target-induced hybridization chain reaction (HCR), which is capable of highly sensitive electrochemical detection of target miRNA. The confinement effect of the HCR/Cas12a system is demonstrated, which s...

Microbial Colony Image Enhancement Algorithm Based on Composite Adversarial D-DCGAN Neural Network

Microbial testing plays a crucial role in medical and biological research, serving as a significant direction in disease prevention and control studies. Traditional manual testing, which involves identifying colonies on Petri dishes is the best method, but it is not only expensiv...

Hierarchical multitask learning for upper extremity rehabilitation assessment using wearable sensors

Upper extremity motor impairment following stroke critically limits patients’ functional independence, making continuous and objective rehabilitation assessment vital for guiding recovery. Current clinical evaluations remain largely subjective, confined to clinical settings, and...

Bayesian Network Meta-Analysis Code and Curated Data for: Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response

This software record contains the custom R scripts and curated study-level tables used to reproduce the revised Bayesian network meta-analysis reported in “Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response.” The workflow...

Bayesian Network Meta-Analysis Code and Curated Data for: Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response

This software record contains the custom R scripts and curated study-level tables used to reproduce the revised Bayesian network meta-analysis reported in “Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response.” The workflow...

Multi-effect synergistic flexible piezoelectric sensor for non-verbal communication of individuals with aphonia

Flexible piezoelectric sensors support wearable human-computer interaction and non-verbal assistive communication for individuals with aphonia, yet simultaneously achieving high sensitivity, fast response, reliable stability, and accurate weak-signal detection remains challenging...

A Thermal-Frequency Locking Method for Permanent Magnet Magnetic Resonance Systems

Abstract Temperature-induced magnetic field drift is a dominant source of slow magnetic field variations in permanent magnet magnetic resonance (PMR) systems, resulting in line broadening, spectral distortion, and imaging artifacts. Conventional methods, such as field-frequency l...

Synthetic β-amino acid polymer promoting keratocyte adhesion and corneal regeneration

Corneal damage ranks among the leading causes of visual impairment globally. Given the prevalence of corneal diseases and challenges of donor cornea shortages and immune rejection, there is an urgent need to develop alternative materials for corneal repair. Although decellular co...