Sun Yat-sen University Cancer Center

Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1 Colorectal Cancer

As biomarkers separated by the arbitrary 5-tumor-cell cutoff at the tumor invasive front, tumor budding (TB) and poorly differentiated clusters (PDC) are recognized as high-risk factors for lymph node metastasis (LNM) in pT1 colorectal cancer (CRC). Nonetheless, relevant findings...

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Peripheral CD4 + T‐Cell Reserve as a Potential Biomarker of CD20 × CD3 Bispecific Antibody Outcomes and BTK Inhibitor–Associated Immune Modulation in B‐Cell Lymphoma

ABSTRACT Bispecific antibodies (BsAbs) targeting CD20 × CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B‐cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. We retrospectively evaluated associations between peri...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Monitoring neutrophil extracellular traps (NETs) related citrullinated histone H3: a novel biomarker of recurrence and metastasis in nasopharyngeal carcinoma

Abstract Objectives Blood-based biomarkers play a crucial role in tumor monitoring. However, for nasopharyngeal carcinoma with recurrence or metastasis (R/M-NPC), there is a notable scarcity of sensitive markers. Citrullinated histone H3 (H3Cit), a key marker of neutrophil extrac...

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...

Placenta-Related PEG10 Inhibits mRNA Decay to Promote Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Abstract Tumors display marked similarities with embryos, exploiting embryonic developmental programs. Beyond the embryo, the placenta also shares features with malignant tumors, such as invasion, immune evasion, and rapid nutrient exchange, highlighting the need for mechanistic...

Applications of the multi-process action control framework in physical activity promotion: a scoping review

The “intention-behavior gap” represents a core bottleneck in the failure of health behavior interventions, with traditional theories offering insufficient explanations for the dynamic mechanisms from intention formation to behavior maintenance. The Multi-Process Action Control (M...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Remimazolam versus sevoflurane for maintenance of anesthesia and postoperative nausea and vomiting in laparoscopic gynecologic oncology surgery: a randomized controlled trial

Postoperative nausea and vomiting (PONV) remains a frequent complication following laparoscopic gynecologic surgery, particularly in female patients with multiple established risk factors receiving volatile anesthetics. Remimazolam, a short-acting benzodiazepine, is an alternativ...

Postoperative radiotherapy for limited-stage high-grade neuroendocrine cervical carcinoma: a retrospective multi-center study from two Chinese institutions

Current treatment guidelines rely on limited retrospective data due to the rarity of high-grade neuroendocrine cervical carcinoma, which lacks consensus on the efficacy of postoperative radiotherapy. To facilitate decision-making support for individual patients, a recursive parti...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...

Structural and Biochemical Analysis of Human Schlafen5 Reveals the Molecular Basis of Its Anti-Tumor Function

Background: Schlafen5 (SLFN5) is an IFN-inducible member of the SLFN protein family involved in immune regulation, viral inhibition and tumor control. Recently, SLFN5 was suggested to inhibit the invasion of many kinds of malignant cells, and its expression positively correlates...

A CCCTC-binding factor (CTCF)-fatty acid desaturase 1 (FADS1) axis regulates oncogenic energy metabolism in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein crucial for 3D genome organization and gene regulation. Previous studies have shown that CTCF overexpression in hepatocellular carcinoma (HCC) is associated with poor prognosis. This study aimed to elucidate th...

A single-cell-informed framework maps context-dependent myeloid damage-response states across cancers

Tumor-infiltrating myeloid cells occupy heterogeneous functional states that are not adequately represented by macrophage abundance or fixed polarization labels. We developed the myeloid damage response index (MDRi), a single-cell-informed framework comprising injury, resolution...

Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies

Chimeric antigen receptor (CAR)-T cell therapy has demonstrated substantial clinical efficacy in pediatric hematologic malignancies; however, its application in pediatric solid tumors remains investigational and is constrained by substantial biological and clinical challenges. Ke...

A multi-temporal MRI radiomics model for early post-ablation recurrence risk stratification in hepatocellular carcinoma

OBJECTIVES: To develop and validate a multi-temporal magnetic resonance imaging (MRI)-based radiomics model for predicting one-year recurrence in hepatocellular carcinoma (HCC) after ablation. METHODS: This retrospective study included 204 patients with HCC who underwent curative...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...