Sun Yat-sen Memorial Hospital

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Association of hydroxychloroquine use with pregnancy outcomes in euthyroid TPOAb-positive women with unexplained recurrent pregnancy loss: a retrospective cohort study

Recurrent pregnancy loss (RPL) is a multifactorial disease. Approximately 40–60% of cases remain unexplained and are classified as unexplained recurrent pregnancy loss (URPL). Thyroid autoimmunity (TAI), particularly thyroid peroxidase antibody (TPOAb) positivity, has been implic...

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

Abstract Monodisperse oxide nanoparticles have attracted attention for biomedical applications. However, conventional synthetic methods often provide limited control over particle size, morphology, and polydispersity. Herein, we report a bottom-up strategy for synthesizing hollow...

Conceptual Interpretation and Practical Teaching Design of Ideal Work and Lost Work: Comments on Chemical Engineering Thermodynamics Textbooks

Abstract Ideal work and lost work are key contents connecting the second law of thermodynamics and engineering practice, and they pose major teaching challenges in chemical engineering thermodynamics courses. Mainstream textbooks widely use a two-step model including adiabatic re...

Integrating bioinformatics and experiments to identify neddylation-related prognostic features in prostate adenocarcinoma

Targeting neddylation represents a promising treatment strategy for prostate adenocarcinoma (PRAD). This study integrated bioinformatics and experimental approaches to identify neddylation-related prognostic genes in PRAD, with the goal of providing new insights. Public datasets...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Periodontitis and adverse outcomes in atrial fibrillation: prospective evidence from the UK Biobank

Abstract Background Periodontitis (PD), a prevalent chronic inflammatory disease, has been implicated in the pathogenesis of various cardiovascular conditions. Although prior evidence suggests an association between PD and incident atrial fibrillation (AF), its influence on the c...

Site-Selective Fe Incorporation in Layered Polar α-In2Se3: Crystal-Chemical Control of Localized Spin States and Ferroic Responses

Abstract Site-selective transition-metal incorporation provides a crystal-chemical route for tuning local bonding, spin states, and ferroic responses in layered inorganic chalcogenides. Here, Fe-incorporated α-In2Se3 is investigated to clarify how Fe site preference and spatial d...

Deubiquitinase USP48 Promotes Gastric Cancer Peritoneal Metastasis by Stabilizing S100A9 to Drive Neutrophil Extracellular Traps Formation

ABSTRACT Peritoneal metastasis (PM) represents the primary cause of death in patients with advanced gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Neutrophil extracellular traps (NETs) have emerged as key mediators of tumor progression, but how cance...

A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Background Superinfection is a major contributor to mortality in patients with severe fever with thrombocytopenia syndrome (SFTS). However, early identification remains challenging because detection of the pathogen causing the superinfection is often delayed. Objective This study...

Self-Sustaining Ce(IV)/Ce(III) Cycle for Spontaneous Surface Hydroxyl Radical Generation

Abstract Advanced oxidation processes are indispensable for water remediation yet face a fundamental activity–selectivity trade-off, where reactive species are competitively quenched by complex aqueous matrices. While surface-confined chemistry, specifically utilizing surface-ads...

Bis-Nitrene Prevails: Ligand-Controlled Divergence from the Conventional Mononitrene Pathway in Dirhodium Catalysis

Abstract Dirhodium paddlewheel complexes are widely used in C–H amination, yet whether bis-nitrene intermediates participate in catalysis remains an open question. Through systematic DFT calculations at the M06L/dgdzvp/SMD level, we show that both axial and bridging ligands exert...

Mixed-Connectivity GeS4 Framework for Wavelength-Dependent Linear Dichroism in Layered GeS2

Abstract Polyhedral connectivity offers a crystal-chemical route for understanding anisotropic properties in low-symmetry solids. Here, layered monoclinic GeS2 is investigated as a mixed-connectivity tetrahedral system composed of corner-sharing Ge−S−Ge bridges and edge-sharing G...

Modulating Charge Transfer Dynamics in Titanium Metal–Organic Frameworks via Conjugated Linker Engineering for Enhanced Photocatalytic Hydrogen Evolution

Abstract This study synthesized three isostructural 2D Ti-based MOFs (Ti–C═C, Ti–C═N, and Ti–N═N) to investigate how conjugated bridge engineering affects their electronic structure, carrier dynamics, and photocatalytic performance. DFT calculations and spectroscopic analyses rev...

Joint association of five insulin resistance indices and frailty index with incident cardiometabolic multimorbidity in individuals with cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study

Insulin resistance and frailty are closely related to cardiometabolic deterioration, yet their joint contribution to the development of cardiometabolic multimorbidity (CMM) among individuals with early-to-intermediate cardiovascular–kidney–metabolic (CKM) syndrome remains unclear...

The Lark-Loop Technique for Onlay Biceps Tenodesis: A Biomechanical, Histological, and Radiological Study in a Rabbit Model

Background: Arthroscopic cortical surface tenodesis has been established as an effective technique for managing lesions of the long head of the biceps tendon (LHBT). However, traditional suture techniques frequently provide insufficient initial mechanical strength, which may cont...

MicroRNAs in HCC: regulatory roles and therapeutic potential

Hepatocellular carcinoma (HCC) ranks among the malignancies with the highest mortality rates worldwide. Owing to the lack of effective diagnostic and therapeutic strategies, patient prognosis generally remains poor. MicroRNAs (miRNAs) function as both oncogenes and tumor suppress...

Prevalence and characteristics of colonic diverticulosis: a retrospective cross-sectional study in Southern China

Abstract Background Recent literature indicated that the prevalence of colonic diverticulosis in China is increasing. However, there is limited information on colonic diverticulosis in China. Our study aims to determine the prevalence and characteristics of colonic diverticulosis...

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable...

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

ABSTRACT Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monooxygenase Et...