Institution
Sun Yat-sen Memorial Hospital
Recent research
- Climate & Environment
Abstract Conventional membranes for nanopollutant removal are constrained by the permeability–selectivity trade-off inherent in size-exclusion mechanisms. Here, we report a surface-charge-regulated MoS2 membrane engineered by anchoring copper nanoparticles and quaternary ammonium...
- Materials & Energy
Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...
- Materials & EnergyOpen access
A MultitaskLarge Reasoning Model for Molecular Science
Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...
- Health & MedicineOpen access
<title>Abstract</title> Background PARP inhibitors (PARPi) are standard front-line maintenance therapy for advanced ovarian cancer, but the efficacy of PARPi retreatment in later lines remains unclear. This phase Ib/II study evaluated the combination of pamiparib (a PARPi) and su...
- AI & ComputingOpen access
Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...
- Health & MedicineOpen access
A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...
- Health & MedicineOpen access
Endometrial cancer (EC) incidence is rising globally, yet diagnosis still depends on invasive procedures, which limit accessibility and delay early detection. A noninvasive, accurate, and accessible diagnostic assay is urgently needed to enable early EC detection. In this multice...
- Materials & Energy
Abstract Photocatalytic CO2 reduction coupled with alcohol oxidation enables the simultaneous production of solar fuels and value-added chemicals, yet redox-site interference on a single photocatalyst remains a key efficiency limitation. Herein, we install spatially separated red...
- Biology
Abstract APOBEC3B (A3B), a key driver of cancer mutagenesis, has emerged as a promising therapeutic target to be ablated to enhance antitumor immunity while reducing intestinal inflammation. Starting from SMC247 (3, 5-diiodotyrosine), a kelp-derived natural product, we identified...
- Engineering & Technology
ImbibitionTheory and Design for Multiscale MicropillarRandom Arrays
Abstract Efficient liquid transport in micrometer-scale confined spaces is crucial for phase-change thermal management systems, like heat pipes (HPs). While multiscale micropillar random arrays (MMRAs) demonstrate enhanced imbibition performance, their structural randomness has h...
- Materials & Energy
Gamma-Irradiation-EnhancedReduction of 99Tc(VII) and Re(VII) by Natural Pyrite
Abstract Reductive immobilization of 99Tc(VII) to sparingly soluble TcO2-type phases is a key process limiting 99Tc transport in the environment. However, the reactivity of natural pyrite toward 99Tc(VII) under conditions relevant to nuclear waste repositories remains poorly unde...
- Engineering & Technology
Abstract Reliable and accurate physiological mechanosensing requires tactile sensors that maintain linearity across ultrawide ranges, yet most reported devices saturate below 500 kPa due to strain hardening and deformation saturation of elastic microstructures. Balancing this lon...
- Health & MedicineOpen access
To develop and validate a machine learning model integrating habitat imaging features before and after neoadjuvant chemoimmunotherapy (NACI) to predict pathological complete response (pCR) to NACI in head and neck squamous cell carcinoma (HNSCC). A multicenter retrospective study...
- AI & ComputingOpen access
Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...
- BiologyOpen access
Matrix Stiffness-Encoded Mechanical Memory Maintains Proliferative Dominance in Metastatic Tumors
Primary and metastatic lesions share similar biological properties despite existing in different microenvironments. A better understanding of the mechanisms underlying the maintenance of phenotypic homogeneity in heterogeneous microenvironments could help identify strategies for...
- BiologyOpen access
Cancer drug response and resistance: molecular mechanisms and combating strategies
Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...
- Health & MedicineOpen access
The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy
Limited studies compare the clinical applications and diagnostic values of cardiovascular magnetic resonance (CMR) versus echocardiography in individuals with hypertrophic cardiomyopathy (HCM). This study was performed to evaluate the diagnostic value of CMR in patients with HCM....
- BiologyOpen access
Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the r...