St.John's Medical College Hospital

Hyperkinetic Movements in an Infant with Citrullinemia Type 1

Citrullinemia type 1 is a rare inborn error of urea cycle metabolism caused by variants in the argininosuccinate synthase 1 (ASS1) gene, resulting in deficiency of the ASS1 enzyme.Affected children typically present shortly after birth with hyperammonemic encephalopathy, vomiting...

The Role of Family Problems in Self-Harm: A 5-Year Retrospective Chart Review

Family problems are the most cited reason for self-harm behaviors in low- and middle-income countries. However, self-harm is often treated as an individual clinical problem rather than one framed by ecological and psychosocial contexts. This study examined the association between...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Outcome of sepsis due to multidrug-resistant bacterial sepsis in a paediatric oncology unit in India: An eight-year retrospective analysis

Abstract Background Multidrug-resistant organisms (MDRO) cause significant morbidity and mortality in hospitalised patients. This is particularly true in paediatric oncology units, especially in low- and middle-income countries with high prevalence of MDRO, like India. We present...

Small Airway Dysfunction Affects One in Five Indian Adolescents: The Multicity APEAL Study

Summary Small airway dysfunction affected one in five adolescents and varied substantially across four Indian cities. Age, sex and study city, but not ambient PM 2.5 or NO 2 , were independently associated with FEF 25–75 .

Evaluating Cell-Free DNA Quantification and Integrity in Breast Cancer Using Fluorometric, Electrophoretic and PCR-Based Platforms

Abstract Background Cell-free DNA (cfDNA) has emerged as a promising biomarker for cancer detection and monitoring. However, different quantification and integrity assessment methods may yield variable results. This study aimed to compare cfDNA concentration and integrity between...