St George's, University of London

New insights into the $$b\rightarrow c \bar{u}q$$ puzzle through Top–Bottom synergies

Abstract Anomalies in the non-leptonic $$\bar{B}^0\rightarrow D^{(*)+}K^{(*)-}$$ B ¯ 0 → D ( ∗ ) + K ( ∗ ) - and $$\bar{B}^0_s\rightarrow D^{(*)+}_s\pi ^-$$ B ¯ s 0 → D s ( ∗ ) + π - decays may be an indication of physics beyond the Standard Model, but the large deviations requir...

Recent Trials of Left Atrial Appendage Closure versus Oral Anticoagulants: An Optimistic View

Abstract Thrombus formation in atrial fibrillation mostly occurs in the left atrial appendage (LAA). LAA closure (LAAC) seems logical to reduce thrombo-embolic AF-related stroke. Early device trials, which predominantly compared LAAC against oral anticoagulant (OAC) with warfarin...

Robust optimisation of RC bridge seismic design considering ground motion suite variability

Robust design optimisation (RDO) of performance-based seismic design (PBSD) has been established as a rigorous approach for obtaining optimal solutions that are minimally sensitive to record-to-record (RTR) variability of ground motions used in nonlinear response history analysis...

Integrating road safety and environmental impact via telematics: Modeling traffic accident risk using vehicle emissions

Abstract High‐emission private vehicles disproportionately contribute to urban air pollution and road accidents, both major public health threats and leading causes of death among young adults. Balancing individual driving behavior with collective environmental responsibility nec...

‘It’s a bit like a legend where you have to tell it again and again’: disclosure practices in single father families via surrogacy

Aims/Background Research has shown that children born through surrogacy to heterosexual and gay couples are often told about this at an early age. However, to our knowledge no studies have explored how single fathers approach telling and talking about their route to parenthood wi...

Risks of adverse respiratory outcomes in adults with cancer over the course of survivorship compared with cancer-free individuals: a matched cohort study using linked English electronic health records

Background We aimed to compare the risks of developing new chronic respiratory conditions, or exacerbating existing ones in survivors of 20 common cancers vs. cancer-free individuals. Methods We conducted a population-based matched cohort study using English electronic primary ca...

Development of a Photostable pH Biosensor Based on mStayGold

Fluorescent proteins (FPs) that are pH-sensitive play a crucial role in investigating pH-related cellular processes, such as endocytosis and exocytosis. Existing pH-sensitive FPs generated from Aequorea victoria green fluorescent protein (GFP), such as superecliptic pHluorin (SEP...

Insights Into Public Attitudes for Effective First Responder Communication During a Simulated Mass Casualty Incident

ABSTRACT Effective public communication during Mass Casualty Incidents (MCI) is essential for safeguarding life, maintaining order, and sustaining trust in emergency responders. Yet, high‐pressure, information‐scarce environments make this communication challenging. This mixed‐me...

EmotionaL and Language Recovery in Aphasia (ELLA): Codesigning and Proof-of-Concept Testing a Novel Intervention

Purpose: People with aphasia are at risk of becoming depressed, anxious, and isolated. They want therapy to focus on improving communication, confidence, and finding ways to live well; family members want to be involved in the therapy process. We aimed to codesign and test a nove...

Clinical outcomes of bleomycin electrosclerotherapy (BEST) for the treatment of slow-flow vascular malformations (SFVMs): a UK single-centre experience

BACKGROUND: Bleomycin Electrosclerotherapy (BEST) is an emerging treatment for slow-flow vascular malformations (SFVMs), utilising electroporation to enhance intralesional bleomycin uptake. This study evaluates the safety and clinical outcomes of BEST in reducing symptom severity...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

A controlled trial of a co-designed virtual reality experience to support wellbeing in students

Abstract Increasing rates of mental health problems among university students require innovative interventions. This study evaluated a multi-sensory, virtual reality (VR) intervention aimed at reducing stress and exam anxiety among students at a healthcare university in the UK. P...

More Than Meets the Eye: A Qualitative Exploration of the Experience of Remission in Chronic Skin Disease

This study explores the lived experience of remission in chronic skin disease (CSD), a clinically significant but underexamined phase of the chronic relapse–remission cycle. Although the psychological burden of active CSD is well established, far less is known about how individua...

Understanding the Complexity of Healthcare Staff Responses to Collective Personal and Occupational Stress Using the Adversity-Activated Development Reflection Tool

The adversity-activated development reflection tool (AART) has been used therapeutically to capture personal growth arising during adversity. Our mixed-methods study used this tool to assess adversity-activated growth in 854 mental and community healthcare workers during the COVI...

Expedited research and approval of medicines for drug-resistant bacterial infections in children.

Multidrug-resistant pathogens cause severe infections with substantial morbidity and mortality in neonates, infants and children, as they do in adults. However, the approval of therapies for multidrug-resistant infections in paediatric patients often lags years behind approval fo...