Sree Chitra Thirunal Institute for Medical Sciences and Technology

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Opioid-Sparing Versus Opioid-Based Analgesia for Craniotomy: A Multicenter Randomized Controlled Trial

Introduction: Pain control remains a challenge after neurosurgery. Opioid-sparing analgesia may provide better pain relief without opioid-related side effects after craniotomy. We aimed to compare analgesia requirement and postoperative pain between opioid-sparing and opioid-base...

Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT India

BACKGROUND: Heart failure with reduced ejection fraction causes high mortality and recurrent hospitalizations in India. We evaluated the effectiveness of the collaborative care model in improving days alive and out of the hospital and overall survival. METHODS: We conducted a par...

Heparin-Ornamented Polycaprolactone–Silk Fibroin Emulsion-Based Nano-/Microfibrous Conduit as a Promising Hemocompatible Tubular Graft

The essential prerequisite of a vascular conduit is to provide a conducive, healthy lumen interface to the flowing blood within it. The persistent problem of late thrombosis, coagulation cascade activation, and vessel occlusion is pertinent in commercial and small-diameter vascul...

Spinal Cord Diffuse Midline Glioma: A Lethal Masquerade

Spinal cord diffuse midline gliomas (DMGs) are rare World Health Organization (WHO) grade IV neoplasms with a poor prognosis. Due to the limited number of reported cases and the absence of standardized treatment protocols, most patients undergo biopsy or subtotal resection follow...