Southwest Hospital

Cancer Cell Membrane-Biomimetic Nanobubbles Carrying Indocyanine Green for Ultrasound/Fluorescence Bimodal Imaging of Colorectal Cancer

Abstract The aim of this study was to construct cancer cell membrane-coated and Indocyanine green-loaded nanobubbles for targeted ultrasound/fluorescence bimodal imaging of colorectal cancer (CRC). ICG-loaded nanobubbles (ICG-NBs) and CT26 (a murine CRC cell line) cancer cell mem...

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

Hydrogen-Associated CXCL2 Drives Adaptive Inflammatory-to-Proliferative State Transition during Skin Wound Healing

Abstract Background Wound healing is an environmentally adaptive process. It requires a tightly coordinated transition from an inflammatory to a proliferative state, which occurs in response to oxidative and inflammatory stress. Molecular hydrogen (H2) is a widely recognized medi...

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

ABSTRACT Spinal cord injury (SCI) induces secondary brain pathology, but the mechanisms linking spinal and brain injury remain unclear. Here, we identify meningeal lymphatic dysfunction as a contributor to secondary brain pathology after SCI. In mice, meningeal lymphatic vessels...

Identification and validation of biomarkers related to integrated stress response in ischemic stroke based on transcriptomics

Abstract Ischemic stroke (IS) is a prevalent cerebrovascular disorder. Integrated stress response (ISR) plays an important role in multiple cerebrovascular diseases, its specific involvement and associated biomarkers in IS remain incompletely understood. This study aimed to ident...

Proximity of anterior mediastinal tumors to the left innominate vein as a predictor of surgical difficulty in subxiphoid VATS: a retrospective analysis

Subxiphoid video-assisted thoracoscopic surgery (SVATS) is widely used for anterior mediastinal tumor resection, yet proximity to major vessels creates technical challenges. This study quantifies how the vertical distance between the tumor and the left innominate vein (LIV) predi...

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with limited therapeutic options. Berberine exhibits renoprotective potential, yet its precise molecular targets and mechanisms of action in DN remain unclear. Berberine targets were retrieved from TCMSP...

SIRT2-mediated deacetylation of ANT3 at Lys96 promotes cell death

Abstract ANT3 is a key molecule that constitutes the mitochondrial permeability transition pore (mPTP) and mediates cell death. Disruption or conformational changes in ANT3 protein homeostasis can trigger cell death. However, the molecular mechanism of ANT3 protein homeostasis re...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy

Abstract Ultrasound-triggered microbubble destruction (UTMD), a non-invasive technique, has been proposed as a promising means of improving the efficacy of radiotherapy against glioblastoma (GBM); however, the underlying mechanisms remain to be fully clarified. Here, UTMD was sho...

Aconitine accidental poisoning: two case reports and literature review

Abstract Introduction Chinese Herbal Medicine (CHM) is widely integrated into clinical practice across Asia and other regions for disease treatment and health maintenance. Aconitine, a potent diterpenoid alkaloid derived from plants of the Aconitum genus (e.g., Aconitum carmichae...

LIDR-TB: large language model-integrated platform for traceable drug repurposing in tuberculosis

Tuberculosis (TB) remains a global challenge exacerbated by the ongoing emergence of drug-resistant strains. Although drug repurposing offers a cost-effective strategy to expedite therapeutic discovery, its application is impeded by the lack of unified, disease-specific framework...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

From Metabolic Dysfunction to Vascular Remodeling

Subclinical cardiovascular disease (SCVD) encompasses a spectrum of vascular abnormalities that emerge well before the onset of overt cardiovascular events. Although a wide range of metabolic, inflammatory, and vascular markers have been associated with SCVD, current assessment s...

Clinical characteristics and risk factors of recurrence for Pseudomonas aeruginosa -associated fracture-related infection following surgical treatment

Aims Pseudomonas aeruginosa (PA), a prevalent Gram-negative pathogen in fracture-related infections (FRIs), presents huge therapeutic challenges due to biofilm formation and multidrug resistance (MDR). Evidence-based guidelines for PA-associated FRI (PA-FRI) remain limited. The a...

Transepithelial potential as a novel biomarker and therapeutic target for epithelial disease and regeneration

The transepithelial potential (TEP) is a stable, long-range bioelectrical gradient maintained across epithelial barriers, generated primarily by polarized ion transport mechanisms such as the Na⁺/K⁺-ATPase and epithelial sodium channels (ENaC). Ranging from a few millivolts to ov...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Engineered CeO 2−x /Au Nanocomposite Enabled Colorimetric‐Terahertz Bimodal Sensing of Urinary Tract Infection Pathogens

ABSTRACT The integration of rapid on‐site screening with precise quantification is critically important for the diagnosis of urinary tract infections (UTIs). However, current detection methods often struggle to balance between screening efficiency and quantitative accuracy. Herei...