Southern University of Science and Technology

Novel mutations of PIKFYVE identified in 322 sporadic cataract patients

BACKGROUND: PIKFYVE, a novel pathogenic gene causing congenital cataract, its association with sporadic cataracts has not been systematically investigated. This study aimed to explore PIKFYVE mutation profiles in major sporadic cataract subtypes. METHODS: We enrolled 322 sporadic...

Interactions between Photochemical and Microbial Degradation on the Pyrogenic Soil-Derived Dissolved Organic Matter

Abstract Photochemical and microbial processes act as primary pathways regulating the transformation and fate of pyrogenic dissolved organic matter (pyDOM) in natural environments, yet their interactions remain poorly understood under different heating conditions. Here, we combin...

Catheter-Associated Soft Tissue Infection Caused by Pantoea piersonii in a Totally Implantable Venous Access Port: The First Report from China

Pantoea piersonii (formerly Kalamiella piersonii) is a recently reclassified environmental Gram-negative bacterium belonging to the family Erwiniaceae. Human infections caused by this organism are extremely rare. Here, we report a rare case of implantable venous access port-assoc...

Mechanism-Guided Antimicrobial Peptide Design through Membrane-Surface Fingerprinting and Graph Diffusion

Abstract Antimicrobial peptides (AMPs) are promising antibiotic alternatives, but current AI-based discovery often relies on sequence labels and lacks explicit modeling of peptide–membrane interactions. We developed Membrane-MaSIF, an MD-derived membrane surface matching model de...

Taming the boundary effect: Femtosecond laser slicing of 4H-SiC enabled by side scribing for improved processability

The 4H polytype of silicon carbide (4H-SiC) has excellent properties such as high electron mobility and high saturation electron velocity; it has therefore become an important material for high-power and high-frequency devices. In the slicing step of wafer fabrication, however, c...

Tuning the Frontier Molecular Orbitals of Aromatic Radicals via Chalcogen Substitution and Heterocyclic Stabilization

Abstract Due to the intrinsic electron-donating effect of chalcogen lone pairs to the aromatic rings, well-characterized radicals, including phenoxy and thiophenoxy, demonstrate that sulfur substitution for oxygen generally raises the electron affinity (EA). Here we report a coun...

Capacity Degradation Mechanisms, Recovery Strategies, and Challenges of Flow Batteries

Redox flow batteries, by virtue of their advantages in power/capacity decoupling, high safety, and long cycle life, have become a strategic support for long-duration energy storage systems; however, capacity degradation remains a bottleneck for their commercialization. This revie...

Thin Phophorus‐Oxide‐Assisted Electrically Pumped Mid‐Infrared Light Emission in a Twisted Black Phosphorus Structure with Polarization Switching

ABSTRACT Efficient and polarization‐switchable on‐chip mid‐infrared light sources are desirable for portable and miniaturized systems for applications in gas sensing, free‐space optical communications, and imaging. The polarization‐switchable function can offer a new information...

Regulating H‐Aggregation via a Thiazole‐Modified Acceptor‐Based Packing Reshaper Toward Highly Efficient and Stable Organic Solar Cells

ABSTRACT Organic solar cells (OSCs) based on non‐fullerene acceptors have achieved power conversion efficiencies (PCEs) exceeding 20%. However, their long‐term stability remains limited by uncontrolled molecular aggregation and morphological degradation in bulk heterojunction (BH...

Emerging Hotspots of Cropland Expansion on Steeper Tropical Terrains Intensify Tropical Forest Carbon Loss

Abstract Tropical deforestation driven by agricultural expansion to meet growing food demand poses a rising threat to the global carbon cycle. While previous studies quantified agriculture‐related carbon losses, the role of cropland expansion remains poorly resolved, partly becau...

On stochasticity of zonostrophic instability

This paper concerns the behaviour of reduced models for turbulence–mean-flow interactions, in particular for the modelling of zonostrophic instability, which accounts for the spontaneous generation of zonal flows observed in many planetary and geophysical fluid systems. In modell...

Interlayer charge-transfer states in SnS2/InSe Van der Waals heterostructures realizing mid-infrared photodetection

Abstract Two-dimensional (2D) van der Waals (vdWs) heterostructures offer a versatile platform where engineered interlayer coupling enables optical processes beyond those of individual materials. Their atomically sharp interfaces support charge-transfer states, directional carrie...

I2M: a box-based detection framework for molecular structure recognition from images

Accurate recognition and reconstruction of chemical structures from molecular images is critical in cheminformatics, with applications spanning drug discovery, materials science, and patent analysis. However, much of this chemical matter exists in implicit forms that are not dire...

Multi-stage Warm-up Seismic Full Waveform Inversion Informed by Electromagnetic Data

Abstract Full waveform inversion (FWI) provides high-resolution velocity models by exploiting the complete information embedded in seismic waveforms. However, the advantages of FWI come with cycle skipping when sufficient information is not available to build an accurate initial...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Structure-guided targeting of the LAT1-4F2hc amino acid transporter in cancer and brain disorders

Abstract The heterodimeric amino acid transporter L-type amino acid transporter 1 (LAT1)-4F2hc (SLC7A5-SLC3A2) is a key regulator of large neutral amino acid exchange, linking extracellular nutrient availability to intracellular growth signaling. It is physiologically enriched at...

Multi-scale parallel time-stepping for 3D simulation of time-domain electromagnetic data with arbitrary transmitter waveforms

Abstract 3D time-domain electromagnetic (TEM) simulations typically employ sequential time stepping, requiring early-time calculations before late times, reducing parallelizability compared to frequency-domain methods. To address this issue, a decomposition method is developed to...

Digitally enabled GP-specialist collaborative care helped improve hypertension outcomes and reduced hospital referrals in China

As China deepens health system reform to strengthen primary care by integrating hospital-based specialist services into community settings, empirical evidence is still limited. This quasi-experimental difference-in-differences analysis examined the effect of the digitally enabled...

Stable Quantum Dot Light‐Emitting Diodes Compatible With Household Alternating Current Electricity

ABSTRACT Like other p‐n junction devices, quantum dot light‐emitting diodes (QLEDs) can only operate with direct current (DC), which is incompatible with household 220 V/50 Hz alternating current (AC), and accelerates device degradation due to constant charge injection and accumu...

Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease

Fibroblast growth factor-23 (FGF23) has been linked to adverse cardiovascular phenotypes, yet its prognostic relevance among individuals with prevalent cardiovascular disease and the potential modifying role of kidney function remain unclear. We analyzed 9,119 UK Biobank particip...