South China University of Technology

Toward Secure Code Generation: Bridging Correctness and Security via Task-Adaptive Vulnerability Modeling and Execution-Based Benchmarking

Large language models (LLMs) are increasingly used for program synthesis, yet they often generate code that is functionally plausible but insecure. Progress in secure code generation has been hindered by benchmarks that are small, non-executable, leak mitigation details, or rely...

De Novo Design of Hydrogen-Bonding Networks for Deterministic Bio-Nano Recognition

Abstract Achieving deterministic control over molecular recognition at high-curvature bio-nano interfaces remains a fundamental challenge. For two decades, DNA-mediated single-wall carbon nanotube (SWCNT) sorting has relied on empirical screening, leaving the underlying recogniti...

Evaluation of Leucine in Hydrate-based CO2 Separation Technology for Synthesized Mixture Gas

Abstract To increase the combustion calorific value, reduce the greenhouse effect of CO2, and prevent corrosion to pipelines, impurity gases such as CO2 and N2 in biogas must be effectively removed. This study investigates the effects of leucine (Leu) on the kinetics and gas sepa...

Haploidentical hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for severe aplastic anemia patients aged 40–65: a multicenter retrospective study

Abstract Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic stem cell transplantatio...

Modular Orthogonal Dual-Channel Gold Nanosensor Platform for Ratiometric Imaging of Tumor-Associated Macrophage M1/M2 Polarization

Abstract The phenotypic balance between M1 and M2 tumor-associated macrophages (MΦs) governs tumor immune homeostasis and immunotherapeutic outcomes. However, in situ visualization of this polarization equilibrium remains challenging. Conventional histological and cytological app...

In Situ Photocurable Janus Hydrogels with Magnetically Guided Anisotropic Conductivity for Myocardial Ischemeia–Reperfusion Injury Treatment and Tissue Adhesion Prevention

Abstract Myocardial ischemia–reperfusion (I/R) injury remains a major clinical challenge associated with reperfusion therapy, often leading to adverse cardiac remodeling and heart failure. Although cardiac patches offered a promising therapeutic strategy, the traditional designs...

A low-complexity, tissue-function-guided engineering workflow for AlphaFold 3-assisted affinity maturation of a CD21 diagnostic nanobody

High-affinity antibodies with reliable tissue-staining performance are needed for reproducible immunohistochemistry (IHC), yet affinity maturation workflows often optimize recombinant-antigen binding and treat staining in formalin-fixed, paraffin-embedded tissue as a downstream v...

Code-breaking spatial practices of Pokémon GO players in Shenzhen, China: Fubao industrial park as a laboratory for studying human behaviour in infrastructure space

Abstract This paper studies human spatial practices in an industrial park in Shenzhen, China and asks how people make space for themselves through ‘code-breaking’ behaviours even in strictly coded, programmed, and predetermined special economic zones (SEZs). The study draws upon...

A few-shot learning framework using multimodal rheological features for local prepreg thickness prediction in multilayer PCBs

As multilayer printed circuit boards (PCBs) move toward high-frequency and high-speed applications, back-drilling stub control and impedance matching have become critical for signal integrity. Their accuracy is strongly governed by the micrometer-level stability of prepreg (PP) d...

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

ABSTRACT Adoptive cell therapy (ACT) remains challenging in solid tumors, where poor tumor infiltration, metabolic heterogeneity, and an immunosuppressive tumor microenvironment (TME) constrain therapeutic efficacy. Here, we developed magnetically and metabolically programmed mac...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...

All-dielectric grating quasi-BIC for upconversion luminescence enhancement and cryogenic temperature sensing

Upconversion nanoparticles (UCNPs) are limited in their applications in non-contact temperature measurement and biomedicine due to their low luminescence quantum efficiency. Traditional surface plasmon resonance (SPR) structures are restricted in their performance and practical a...

Extending the technology acceptance model with trust and perceived risk to explain young-old adults’ virtual reality technology adoption

Virtual reality (VR) technology is a valuable tool to address the evolving needs of young-old adults. This study investigated the factors influencing the adoption of VR technology among young-old adults, extending the technology acceptance model by incorporating trust and perceiv...

Undrained capacity of shared triple-bucket anchor foundations under combined horizontal and torsional loading

Shared anchors offer a promising solution for reducing mooring system costs in floating offshore wind arrays. However, their capacity may be reduced by varying resultant horizontal and torsional mooring loads under complex environmental loading. Numerical analyses are conducted t...

Regioselective 1,2-Hydroamination of Conjugated Enynes for Accessing Propargylamines via Dual Photoredox/Cobalt Catalysis

Abstract The photoredox-catalyzed selective addition of N–H bonds across unactivated 1,3-enynes represents a promising and sustainable transformation, enabling efficient access to high-value-added propargylamines. Current state-of-the-art advancements via photoredox catalysis rel...

Surrogate-assisted boundary-oriented multi-objective optimization of semi-rigid steel frame-brace-damper systems

Brace-damper co-design can improve the seismic performance of steel frames, but current optimization practice is limited by three issues: semi-rigid connection flexibility is often neglected; conventional Pareto searches may represent the attainable performance envelope unevenly;...

Exploring the adoption of wearable physical activity monitoring technology amongst older adults in Hong Kong: a grounded theory approach

This study explored the attitudes and experiences of older adults who had used Wearable Physical Activity Monitoring Technology (WPAMT) for at least 30 days, identifying factors influencing continued use and discontinuation. Employing grounded theory, face-to-face interviews with...

Motion sickness incidence estimation incorporating back-measured torso biodynamic response: Modeling and real-vehicle evaluation

Accurate estimation of motion sickness incidence (MSI) is important for vehicle comfort optimization and motion-sickness mitigation. Conventional vibration-based functional models generally use vehicle acceleration directly and therefore do not account for mechanical transmission...

Groundwater regulates the spatial pattern of photosynthesis in the contiguous United States

Abstract Plants can access water stored in aquifers to sustain their activity, releasing moisture into the atmosphere—a critical survival mechanism during drought. Understanding the role of groundwater in regulating photosynthesis is thus key for modelling land-atmosphere interac...

Cross-Rotor Coassembly of AIEgens for Dual-NIR-II Laser-Enhanced Imaging-Guided Phototheranostics

Abstract Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), offers a minimally invasive approach with precise spatiotemporal control for cancer treatment. However, conventional photosensitizers are prone to aggregation-caused quenching, which lower...