Sixth Affiliated Hospital of Sun Yat-sen University

Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1 Colorectal Cancer

As biomarkers separated by the arbitrary 5-tumor-cell cutoff at the tumor invasive front, tumor budding (TB) and poorly differentiated clusters (PDC) are recognized as high-risk factors for lymph node metastasis (LNM) in pT1 colorectal cancer (CRC). Nonetheless, relevant findings...

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

When to stop? assessing the appropriate cycle of ovulation induction with timed intercourse in letrozole- or clomiphene citrate-sensitive polycystic ovary syndrome

To study how many cycles of ovulation induction with timed intercourse were appropriate for PCOS patients sensitive to letrozole or clomiphene citrate. A prospective study. A total of 655 women with PCOS were included who underwent 2633 cycles with ovulation induction followed by...

Three-decade trends in nonalcoholic fatty liver disease across 204 countries and territories

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading chronic liver disease globally, driven by the rising incidence of obesity, type 2 diabetes, and metabolic syndrome. Despite the increasing burden, most studies focus on prevalence rather than incidence, leaving a g...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Effectiveness of anti-TNF therapy after prior ustekinumab exposure in Crohn’s disease: A propensity-weighted cohort study

Abstract Background As ustekinumab is increasingly used earlier in Crohn’s disease (CD), evidence regarding the effectiveness of subsequent anti-tumor necrosis factor (TNF) therapy remains limited. We compared anti-TNF outcomes after prior ustekinumab exposure with first-line ant...

Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer

Emerging evidence implicates insomnia as a potential risk factor in carcinogenesis, potentially involving systemic inflammation, circadian disruption, and microbiome alterations. However, the molecular associations linking insomnia-related features to colorectal cancer (CRC), par...

Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

The conserved non-coding RNA 7SK is a well-established global transcriptional repressor, yet its context-specific functions in cancer and therapy resistance remain paradoxical. Here, we resolve this paradox by uncovering a dual-axis mechanism through which 7SK drives colorectal c...

Prophylactic intra-aortic balloon pump in gastrointestinal cancer surgery: a potential approach to mitigate perioperative ischemic risk in severe coronary artery disease

Patients with severe coronary artery disease (CAD) requiring time-sensitive gastrointestinal cancer surgery face a dual challenge: perioperative myocardial ischemia and surgical bleeding. The optimal management strategy in this setting remains undefined. This single-center retros...

Neural-specific UBAP2L deficiency causes developmental delay and cortical abnormalities in mice

Rare UBAP2L variants have been linked to neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), but the role of UBAP2L in brain development remains unclear. Here, we generated neural-specific conditional knockout mice for Ubap2l using Nestin-Cre system, incl...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Efficacy and safety of upadacitinib for Crohn’s disease in patients in East Asia: a post hoc analysis of randomized phase 3 studies

Abstract Background Upadacitinib is an oral Janus kinase inhibitor approved for the treatment of moderate-to-severe Crohn’s disease (CD). This post hoc analysis reports the efficacy and safety of upadacitinib for CD in patients in East Asia enrolled in the phase 3 clinical trials...

Mitochondrial DNA mutation triggers early-onset intestinal epithelial cell dysfunction during acute colitis

Abstract Background Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial ce...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

siRNA-mediated mismatch repair disruption synergizes with oxaliplatin to restore immune surveillance in microsatellite-stable colorectal cancer

Proficient mismatch repair/microsatellite-stable colorectal cancer (pMMR/MSS CRC), which represents the majority of clinical cases, exhibits low tumor mutational burden and minimal responsiveness to immune checkpoint blockade. Disrupting the MMR system has been shown to resensiti...

TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics analysis was performed on TCGA-CHOL data...

ABHD11-Mediated mtDNA Transcription Restored Mitochondrial Function to Attenuate Cardiomyocyte Ferroptosis After Myocardial Infarction

BACKGROUND: Cardiomyocytes exhibit marked susceptibility to ferroptosis after myocardial infarction (MI), rendering ferroptosis inhibition a promising therapeutic strategy to mitigate ischemic myocardial injury. Although mitochondrial dysfunction is recognized as a core driver of...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Targeted uterine artery infusion of bone marrow-derived mesenchymal stem cells for severe intrauterine adhesions: a randomized controlled trial with exploratory translational analyses

Severe intrauterine adhesions (IUA) represent a profound failure of endometrial regeneration, characterized by excessive fibrosis and vascular insufficiency. Mesenchymal stem cell-based therapies show regenerative potential, but clinical evidence is inconsistent, and optimal deli...

Roles of cerebrospinal fluid metabolites in neuromyelitis optica spectrum disorder: Insights from Mendelian randomization

Neuromyelitis optica spectrum disorder (NMOSD) is a rare multifocal inflammatory disease that primarily affects the optic nerve and spinal cord, leading to visual loss and paralysis. Although current research has identified numerous biomarker changes in the cerebrospinal fluid (C...