Siriraj Hospital

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

ABSTRACT Aims Measurable residual disease (MRD) is a key prognostic marker for patient survival. This study evaluated concordance between 10‐color flow cytometry and next‐generation sequencing (NGS)–based immunoglobulin heavy chain (IGH) gene assays for MRD detection and to asses...

PARP inhibition induces a redox-dependent dormant reservoir vulnerable to disulfiram in high-grade serous ovarian cancer

Resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in high-grade serous ovarian cancer (HGSOC) is increasingly driven by non-genetic drug-tolerant dormant cell populations, yet the adaptive programs sustaining these cells remain poorly understood. Here, we established a...

Clinical and Immunological Responses to Dermatophagoides farinae Allergen Immunotherapy in Dogs With Atopic Dermatitis

ABSTRACT Background Atopic dermatitis (AD) in dogs is a prevalent allergic disorder associated with environmental allergens, including the house dust mite Dermatophagoides farinae (Df). Hypothesis/Objectives To describe clinical and immunological changes over time in dogs with ca...

Landscape of industry-sponsored oncology trials across the Thai Society of Clinical Oncology (TSCO): a 12-year multicenter analysis

Cancer remains a major global health challenge and is a leading cause of morbidity and mortality in Thailand. Industry-sponsored oncology trials (ISOTs) provide critical access to innovative therapies, including targeted agents, immunotherapies (IO), and antibody–drug conjugates...