Sir Run Run Shaw Hospital

Polypoid manifestations of mucosal prolapse syndrome: a retrospective analysis of 29 cases

This retrospective study evaluated the clinical, endoscopic, and histopathological features of polypoid manifestations of mucosal prolapse syndrome (MPS). Patients diagnosed with polypoid MPS by endoscopic biopsy between December 2016 and May 2025 at two tertiary hospitals in Chi...

CGA-DTA: interaction-conditioned graph topology and cross-graph attention for drug--target affinity prediction

Drug–target affinity (DTA) prediction supports virtual screening in computer-aided drug discovery, but graph-based models still face two linked limitations. Adaptive-topology methods usually learn drug and protein graphs independently and merge them only at the prediction head, w...

User experiences and community responses to generative artificial intelligence health advice on reddit: topic modeling and content analysis study

Generative artificial intelligence (AI) chatbots are increasingly used for everyday health information seeking, yet little is known about how users interpret AI-generated health advice outside clinical encounters or how online communities respond when that advice is shared. This...

Targeted NAD + Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions

ABSTRACT Regeneration of the injured endometrium requires re‐establishment of a permissive microenvironment that supports coordinated epithelial renewal, angiogenesis, and matrix remodeling. However, this regenerative transition remains incomplete in intrauterine adhesions, sugge...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Joint associations of problematic smartphone use and cyberbullying victimization with depressive and anxiety symptoms among Chinese primary and secondary school students: a large-scale school-based study

Problematic smartphone use (PSU) and cyberbullying victimization (CBV) are independently associated with emotional problems among adolescents. However, whether their co-occurrence is associated with a greater burden of depressive and anxiety symptoms remains unclear. This study e...

The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent malignancy worldwide, encompassing tumors derived from the mucosal epithelia of the oral cavity, pharynx, larynx and other head and neck regions. Most patients are diagnosed at an advanced stage due t...

Recent Advances in Transition‐Metal‐Catalyzed Cyclization Reactions of α‐Diazocarbonyl Compounds

α‐Diazocarbonyl compounds, as a class of versatile organic synthons, occupy a pivotal position in the field of organic chemistry. Their unique structural features endow them with rich reactivity, enabling decomposition under thermal, photolytic, or transition‐metal‐catalyzed cond...

Developing a health values framework for patients with cardiovascular-kidney-metabolic syndrome: a qualitative exploration through the lens of social determinants of health

Abstract Background Despite global calls for the advancement of patient-centered care, care planning often remains poorly aligned with patients’ lived social contexts and core values. This study aimed to understand what matters most to patients with cardiovascular-kidney-metaboli...

FXYD1 participates in regulating sperm motility, capacitation, and acrosome reaction via associations with NKA/NCX1, ion homeostasis, membrane potential, and acrosin activity, with distinct localization in mouse and human sperm

Abstract Background FXYD1 plays a significant role in diverse biological processes and diseases. However, whether FXYD1 regulates sperm function is unknown. Methods We investigated the effects of FXYD1 on motility, capacitation, and the acrosome reaction, as well as the potential...

Potential Mechanisms Linking Excessive Testosterone to PMOS: Insights from Network Toxicology and Machine Learning

Background/Objectives: Polyendocrine metabolic ovarian syndrome (PMOS) is characterized by hyperandrogenism, particularly excessive testosterone, as a core clinical feature and a key pathogenic metabolite, yet its molecular mechanisms remain incompletely understood. Methods: This...

Increasing Global Burden of Inflammatory Bowel Disease and Its Attributable Anemia in Adults Aged 60 Years and Older: A Comprehensive Analysis of the Global Burden of Disease Study 2021

OBJECTIVE: To quantify the global burden of inflammatory bowel disease (IBD) and IBD-attributable anemia in adults aged ≥ 60 years across 204 countries and territories from 1990 to 2021 and their projected trends through 2045 based on the Global Burden of Disease (GBD) 2021 datab...

Antibiotic-loaded PMMA bone cement promotes diabetic wound healing via induced membrane formation: a transcriptomic and mechanistic study

Abstract DFU is a prevalent complication among diabetic patients, significantly impairing their quality of life.PMMA-induced membrane therapy has gained increasing attention as a specialized healing tissue closely linked to bone regeneration. This study aims to explore the impact...

Thermogenic adipose tissue as a therapeutic target: from human heterogeneity to pharmacological translation

Thermogenic adipose tissue, including classical brown adipose tissue (BAT) and inducible beige adipocytes, has re-emerged as a promising therapeutic target in the obesity field. Because BAT can convert chemical energy into heat while also playing a role in regulating systemic glu...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Preoperative C-Reactive Protein–Albumin–Lymphocyte Index and Related Clinical Factors Associated With Postoperative Complications Following Cholecystectomy in Acute Cholecystitis: A Retrospective Study

AIM: Laparoscopic cholecystectomy (LC) is the primary treatment for acute cholecystitis (AC), although various postoperative complications may still occur. Inflammatory composite indices have gained increasing attention in surgical risk assessment; among them, the C-reactive prot...

SOX2-OT potentiates E2F1-HES6 interaction to suppress natural killer cell activity and mediate immunosuppression in lung adenocarcinoma

Lung adenocarcinoma (LUAD) escapes immune surveillance by building an immunosuppressive tumor microenvironment. Within that microenvironment, impaired natural killer (NK) cell function is considered an important mechanism promoting tumor progression and immune escape. However, th...

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2 – JAM3 tight junction structure and the blood–brain barrier integrity

Abstract Primary brain calcification (PBC) is a neurodegenerative disorder characterized by bilateral brain calcification. JAM2 is a PBC causative gene, encoding the tight junction protein JAM2 and critical for blood–brain barrier (BBB) integrity, with an uncertain pathogenic mec...

Exploring parents’ experiences of palliative care in the pediatric intensive care unit (PICU): a meta-synthesis of qualitative research

Abstract Background When the goals of care for a critically ill child in the pediatric intensive care unit (PICU) shift from curative treatment toward palliative care, parents’ experiences are often complex and multifaceted. This review aimed primarily to synthesize qualitative e...

Silk-based materials: Emerging for tendon/tendon-bone regeneration

ABSTRACT: The tendon and tendon-bone interface injuries have long been an issue for clinical practice. Autologous or allogeneic transplantation has been found to be a good method for repairing injuries; however, many factors limit the application of autologous and allogeneic tran...