Sir Run Run Shaw Hospital

Nanoporous titanium implant functionalized with sustained strontium release orchestrates immune microenvironment for enhanced osseointegration

Objectives Insufficient osseointegration remains a major limitation of dental and orthopedic implants. This study aimed to develop a strontium-releasing nanoporous titanium surface (TDS) with improved interfacial stability and immunomodulatory capacity to promote implant osseoint...

Enzymatic cross-linking collagen-based bioink for 3D bioprinting of endometrial model with endometrial epithelial organoids

The human endometrium, a dynamic tissue responsive to sex hormones, plays a pivotal role in female reproduction and menstrual cycling, comprising diverse cell populations including epithelial and stromal cells. The development of in vitro endometrial models holds substantial pote...

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

ABSTRACT Dry eye disease (DED), a chronic disorder affecting nearly half the global population, is perpetuated by oxidative stress, inflammation, and tear film instability. Constrained by short precorneal residence and monotherapy, DED therapies necessitate frequent dosing and po...

Efficacy and safety of radiofrequency ablation for high-risk locations of T1aN0M0 papillary thyroid carcinoma: a retrospective cohort study

The 2024 Expert Consensus has broadened the potential indications for thermal ablation in papillary thyroid carcinoma (PTC). This study classified PTC nodule locations to assess the efficacy and safety of radiofrequency ablation (RFA) for T1aN0M0 PTC in high-risk locations (HRL)....

Next-Generation Pharmacotherapy for Uterine Leiomyomas: Combining Metformin and Ulipristal Acetate as Neoadjuvant and Adjuvant Interventions to Minimally Invasive Procedures

Uterine fibroids (leiomyomas) are the most common benign tumors of the myometrium in women of reproductive age. They are a major cause of heavy menstrual bleeding, pelvic pressure and pain, and reduced fertility in women of reproductive age. This scoping review aims to examine th...

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice

Abstract Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

A systems-level dissection of aging and longevity mechanisms powered by an evidence-routed AI knowledge graph

Abstract Aging is a complex biological process influenced by numerous molecular and cellular factors. A systems-level understanding of these mechanisms is essential for identifying key regulatory processes and prioritizing effective interventions. Here, we present a comprehensive...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain

Abstract Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of APA in brain cell types...

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation.

activation in the lung.

Mendelian Randomization and Machine Learning for Anatomical Subtyping of Adolescent Sleep Apnea

Introduction and aims Obstructive sleep apnea (OSA) is associated with dentofacial skeletal and soft-tissue anomalies, but whether these anatomical pathways contribute independently, and whether they define clinically distinct subtypes, remain unresolved. We integrated genetic ca...

Social capital factors in healthcare AI implementation: a qualitative systematic review

Fragmented healthcare systems often hinder the seamless adoption of artificial intelligence (AI). Traditional frameworks frequently view AI adoption as a discrete technical acquisition, overlooking the socially negotiated processes and team-level dynamics crucial for integration....

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Longitudinal associations among exercise atmosphere, physical self-esteem, and aging attitudes in older adults

Physical self-esteem and aging attitudes are two key psychological factors associated with well-being in older adults. While previous research has emphasized the role of exercise in promoting healthy aging, how these factors dynamically interact within varying exercise environmen...

Discovery and initial validation of biomarkers for early detection and monitoring of laryngeal cancer using a blood-based microRNA

Laryngeal cancer (LC) is a common head and neck malignancy for which early detection and disease monitoring remain clinically important. We sought to identify and validate microRNAs (miRNAs) as potential non-invasive biomarkers for LC. Candidate miRNAs were screened through diffe...

Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models

Postural instability and gait difficulty (PIGD) represent a debilitating clinical subtype of Parkinson’s disease (PD) that is largely refractory to dopaminergic replacement therapy. While clinical imaging implies that the cerebellum is involved in these axial deficits, the specif...

Anticipated acceptance of generative AI among older adults with chronic heart failure: a qualitative study guided by UTAUT

Chronic heart failure imposes a substantial disease burden on older adults, who face considerable challenges in post-discharge self-management. Generative artificial intelligence tools offer the potential to provide personalised, real-time health information support. However, how...