Sir Run Run Shaw Hospital

Latent profile analysis of sleep quality among newly employed nurses: a cross-sectional study

<title>Abstract</title> Background Newly employed nurses face unique challenges during role transition, making them particularly vulnerable to sleep disturbances. However, traditional assessments overlook the heterogeneity of sleep problems in this population. This study employed...

Efficacy of Concentrated Growth Factors in Regulating Macrophage Immune Responses and Promoting Wound Healing After Plastic Surgery

OBJECTIVE: To evaluate the clinical effect of concentrated growth factor (CGF) on postoperative wound healing after plastic surgery, and to explore its association with changes in local immune-inflammatory markers and macrophage-related indicators. METHODS: Ninety-six patients wi...

Niche-dependent immunometabolic regulation of tissue repair and regeneration

Tissue repair restores structural integrity and functional homeostasis after injury through coordinated interactions among immune cells, structural compartments, and extracellular matrix remodeling, ultimately culminating in tissue-resident regenerative programs. Increasing evide...

The Impact of 2D Dashboard Spatial Orientation on Gestural Interaction Performance and Ergonomic Concerns in Virtual Reality

Default vertical dashboard orientations in virtual reality (VR) lack systematic ergonomic validation across mainstream gestural interaction paradigms. This study compares four dashboard orientations (horizontal, 60° inclined upward, vertical, 60° inclined downward) under direct h...

In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice

Abstract A systematic proteomic profile of oocytes from early-stage follicles, particularly primordial follicles, is critical to protect female reproductive capacity in the context of chemotherapy, yet progress has been hindered by the rarity of oocyte samples and technical chall...

Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter

Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system...

Aqueous Humor Proteomics Reveals the Molecular Basis for Differential Treatment Responses in nAMD and pmCNV

Purpose: Choroidal neovascularization (CNV) causes vision loss in neovascular age-related macular degeneration (nAMD) and pathologic myopia-related CNV (pmCNV). Despite shared clinical features, they respond differently to treatment. This study compared aqueous humor (AH) proteom...

Influencing Factors of Air Bubble-Induced Pressure Difference in Drainage Tubes: An In Vitro Study

AIM: This study evaluated the effect of the presence of air bubbles in a drainage tube on its pressure difference and analyzed the relationship between air bubble volume, tube diameter, drainage fluid viscosity, and pressure difference. Accordingly, it provides a theoretical basi...

Surgery is associated with improved survival in elderly patients with gastric cancer based on a competing risk analysis of the SEER database

Abstract Background Gastric cancer (GC) is one of the most common malignancies worldwide and occurs with a particularly high incidence in the elderly population. Given the substantial burden of comorbidities and the elevated risk of non–cancer-related mortality in older patients,...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Risk factors for Gram-negative bacterial bloodstream infections: a systematic review and meta-analysis with subgroup analyses for carbapenem-resistant organisms and Acinetobacter baumannii

Abstract Background Gram-negative bacterial (GNB) bloodstream infections (BSIs), particularly those caused by carbapenem-resistant GNB (CR-GNB) and Acinetobacter baumannii (AB), are associated with substantial morbidity and mortality. This study aimed to provide, to our knowledge...

Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance

Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR) in colorectal cancer...

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis

Abstract N 6 -methyladenosine (m 6 A) RNA modification plays critical roles in physiological and pathological processes. Our prior study demonstrated that IGFBP5 expression is upregulated in the ischemic limb, whereas endothelial-specific IGFBP5 knockout (Igfbp5 EKO ) protects ag...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis.

A-FGF16 axis may offer novel therapeutic strategies for ischemic disease.

Associations of dietary inflammatory index with respiratory tract infections among US adults and the mediating roles of systemic inflammation markers

Respiratory tract infections (RTIs) remain a major public health burden among adults, with substantial interindividual heterogeneity in susceptibility. Chronic low-grade systemic inflammation has been proposed as an important host-related determinant of infection risk, and the di...