Singapore National Eye Center

Comparison of Biometric Measurements Between Anterior Segment Hyperparallel and Swept-Source Optical Coherence Tomography

Purpose: To evaluate the inter-device agreement between hyperparallel optical coherence tomography (HP-OCT) and swept-source OCT (SS-OCT) in quantitative anterior segment parameters. Methods: Phakic subjects aged ≥40 years were consecutively recruited at a tertiary eye hospital....

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

Surgical outcomes of trabecular micro-bypass minimally invasive glaucoma surgery devices in eyes with high myopia: a 24-month retrospective multicenter cohort study

BACKGROUND: To describe outcomes of two trabecular bypass minimally invasive glaucoma surgery (MIGS) devices in highly myopic (HM) eyes with glaucoma up to 24 months postoperatively. METHODS: A retrospective, observational multicenter study of HM eyes (phakic refractive spherical...

Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema

This analysis evaluated the impact of early intraretinal fluid (IRF) reduction on long-term visual outcomes in patients with diabetic macular edema (DME). This was a treatment-agnostic, post hoc analysis of pooled data from patients with DME in YOSEMITE/RHINE (NCT03622580/NCT0362...

Update on the Physiopathology of Keratoconus

Keratoconus (KC) is a progressive corneal ectasia characterized by stromal thinning, steepening, and biomechanical instability. Although historically considered primarily a structural disorder, current evidence supports a multifactorial pathogenesis involving complex interactions...

Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations

Stromal keratophakia was first introduced by Jose Ignacio Barraquer in the 1960s as a refractive procedure involving the implantation of a stromal lenticule into a lamellar keratectomy bed of a recipient cornea. By increasing central corneal thickness, the added lenticule induced...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...

Evaluation of a novel multi-purpose ophthalmic block simulator amongst ophthalmology trainees

Abstract Purpose Training to perform ophthalmic blocks is often done on actual patients by trial and error. Higher complication rates and poor patient experience occur from a suboptimal block. We assess the efficacy of a novel ophthalmic block simulator via a pilot study. Design:...

Optic nerve head blood flow autoregulation during isometric exercise in primary open‐angle glaucoma assessed by laser speckle flowgraphy

Abstract Purpose To assess optic nerve head blood flow (ONHBF) autoregulation in patients with early‐ to moderate‐stage primary open‐angle glaucoma (POAG) and age‐ and sex‐matched healthy controls using laser speckle flowgraphy (LSFG) and isometric handgrip exercise. Methods In t...

Incidence and Risk Factors for Progression of Pachychoroid Subtype

Importance The incidence and determinants of progression across the pachychoroid subtype remain incompletely characterized, limiting risk stratification and follow-up strategies. Objective To evaluate progression, diagnostic transitions, and associated risk factors in eyes with p...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...