Sichuan University of Science and Engineering

Advancesand Challengesin Nanodelivery Systems forRNA Vaccines

Abstract RNA vaccines have become a transformative technology in infectious disease prevention and cancer treatment, thanks to their rapid development, high immunogenicity, and scalability in production. However, the clinical application of RNA vaccines faces significant challeng...

Non-MonotonicStructural Evolution and Enhanced NonlinearOptical Performance in Li x Ag1– x GaTe2 Solid Solutions

Abstract A series of LixAg1–xGaTe2 (x = 0.1 ∼ 0.6) solid-solution single crystals was grown by the Bridgman method. The inherent instability of LiGaTe2 and the narrow bandgap of AgGaTe2 are simultaneously surmounted, and the structure and nonlinear optical performance are thereby...

Electrochemical Cytosensor with Dual-Site Recognition Fabricated by In Situ Catalase-Encapsulated Metal–Organic Frameworks for Isolation and Detection of Circulating Tumor Cells in Whole Blood

Abstract Circulating tumor cells (CTCs) are critical biomarkers for cancer prognosis and treatment monitoring, yet their detection remains challenging due to low abundance and phenotypic heterogeneity. Herein, we developed a dual-aptamer-conjugated electrochemical cytosensor usin...

High-Capacity and Rapid Radioiodine Capture from Gasand Water by Triazine-Functionalized Collagen Fibers

Abstract Effective elimination of radioactive iodine species from nuclear waste is critical for ecological protection, human health safety, and the sustainable development of nuclear energy. Herein, a collagen fiber-based iodine adsorbent (ACFT) was fabricated via glutaraldehyde-...

Sustainable High-PerformancePolylactide/Poly(butyleneadipate- co -terephthalate) Blend Films via IntegratingInterfacial Compatibilization with Biaxial Stretching

Abstract A sustainable strategy integrating reactive compatibilization with biaxial stretching was developed to produce high-performance polylactide/poly(butylene adipate-co-terephthalate) (PLA/PBAT) blend films. Pentamethylene diisocyanate (PDI) served as a reactive compatibiliz...

A Cross-Variable Time-Series Transformer Architecture Integrating Physical Features for Photovoltaic Energy Forecasting

Accurate photovoltaic (PV) energy forecasting is vital for grid stability and the global low-carbon transition. However, existing data-driven and channel-independent PV energy forecasting models struggle to capture nonlinear meteorological couplings, heterogeneous physical scales...

Aminosugar-FunctionalizedMicrospheres with SuperiorBoron Selectivity and Reusability: Synthesis, Performance, and ChelationMechanism

Abstract Traditional adsorbents often face challenges such as low adsorption capacity, poor selectivity, difficulties in regeneration, and limited stability, rendering them inadequate for boron-containing wastewater treatment. In this study, glycerol methacrylate (GMA) is graft-c...

Root traits are strongly associated with nitrogen uptake efficiency in contrasting rapeseed genotypes

Abstract Screening the higher nitrogen (N) uptake efficiency (NUpE) rapeseed ( Brassica napus L.) genotype (N-efficient-genotype) and exploring the N efficient uptake mechanism could be an ideal way to meet the environmentally use of valuable N and the increasing demand for edibl...

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

ABSTRACT Hyperbilirubinemia, which stems from bilirubin accumulation caused by liver failure, can lead to jaundice, multi‐organ damage, and mortality. Hemoperfusion is the most effective detoxification approach, and its efficacy critically depends on the adsorbent system. However...

Preparation andEvaluation of Biopolysaccharide-BasedTemperature-Resistant Drilling Fluid Additives

Abstract Xanthan gum (XG), valued for its environmental friendliness and multifunctionality, has been extensively utilized in drilling fluids. However, its inadequate thermal stability at elevated bottomhole temperatures encountered in deep drilling operations has constrained its...

Catalytic Regulation of Reaction Networks in High-Concentration 5-Hydroxylmethylfurfural Oxidation

Abstract The selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is a key catalytic transformation for the production of renewable polymers. Although near-quantitative FDCA yields can be achieved under dilute conditions, increasing substrate...

Discovery, Synthesis,and Biological Evaluation of1,3,4,5-Tetrahydro-6 H -pyrano[4,3- c ]isoquinolin-6-one Derivatives as Novel and Highly SelectivePARP1 Inhibitors

Abstract Developing highly selective PARP1 inhibitors is a promising strategy to improve the therapeutic window compared with dual PARP1/2 inhibitors. Through structure-guided design and optimization, we developed (R)-A17, a novel, highly selective PARP1 inhibitor featuring a uni...