Shiraz University of Medical Sciences

Interventions to mitigate fatigue in shift workers: a systematic review

Shift work disrupts circadian regulation, impairs sleep quality, and hinders recovery, increasing occupational safety risks. Most existing reviews focus on single occupations or isolated countermeasures, limiting cross-industry synthesis. This systematic review synthesized workpl...

Comparison of a pH-adjusted intranasal midazolam spray with off-label intranasal use of midazolam injection as preoperative sedation among pediatric patients undergoing inguinal hernia surgery: a randomized clinical trial

Preoperative anxiety in pediatric patients can lead to significant psychological consequences. Midazolam, a fast-acting benzodiazepine, can be administered intranasally. However, the injectable solution, when used intranasally, may cause mucosal irritation. This study aimed to co...

Mechanistic insights into the inhibition of insulin amyloidogenesis and associated toxicity by the p. M14L variant of exenatide

Insulin fibrillation and the subsequent formation of toxic amyloid aggregates are significant challenges in therapeutic development and are associated with cellular proteotoxicity. In this research, we explored how the p.M14L exenatide variant affects the formation of insulin amy...

Unveiling the antiviral activity of Adiantum capillus-veneris L. against influenza A(H1N1)

The influenza virus poses a global health threat, with current management involving antiviral drugs and annual vaccination, although challenges of resistance exist. Herbal medicine, particularly Adiantum capillus-veneris L., traditionally used for respiratory diseases, shows anti...

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

A native dairy-derived Streptococcus thermophilus potentiates docetaxel efficacy by modulating apoptotic and PI3K/AKT/mTOR signaling pathways in MCF-7 breast cancer cells

Docetaxel (DTX) is a widely used chemotherapeutic agent for breast cancer; however, its clinical application is limited by dose-dependent toxicity and chemoresistance. This study investigated the chemosensitizing potential of a native dairy-derived S. thermophilus strain in combi...

Electronic Nicotine Delivery Systems Use Among Students in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis of 60 Studies on Prevalence and Socioeconomic Determinants

Background The rapid global increase in Electronic Nicotine Delivery Systems (ENDS) use among youth is a pressing public health concern. However, comprehensive data for the Eastern Mediterranean Region (EMRO) remains sparse. This study aimed to conduct a systematic review and met...

Treatment failure and associated factors in pediatric Hodgkin lymphoma: a decade of institutional experience from a middle-income country

Despite excellent overall outcomes in pediatric Hodgkin lymphoma (HL), a subset of patients experiences relapse or primary refractory disease, necessitating intensive salvage therapy and exposing them to additional treatment-related toxicity. Data regarding treatment failure and...

Evaluation of phototherapeutic antibacterial activity of LED-illuminated curcumin nanomicelles against multidrug-resistant K. pneumoniae harbouring extended-spectrum β-Lactamase (ESBL) and carbapenemase resistance genes

This study evaluated the antibacterial effect of photodynamic therapy (aPDT) using nanomicelle-encapsulated curcumin photosensitizer (PS) against drug-resistant clinical isolates of Klebsiella pneumoniae and K. pneumoniae ATCC 13883™. In this study, nanomicelle curcumin prepared...

Patient- and care-related factors associated with central line-associated bloodstream infection in adult intensive care units: a retrospective matched case-control study at a tertiary referral center

Central line-associated bloodstream infection (CLABSI) is an important preventable healthcare-associated infection in intensive care units (ICUs). This study evaluated patient- and care-related factors associated with CLABSI and described the causative microorganisms in adult ICU...

Assessing the efficacy of a case-based clinical reasoning workshop for medical students: a randomized controlled trial

Background Clinical reasoning is a core competency in medical education, yet many undergraduate medical students struggle to develop flexible diagnostic thinking and well-organized knowledge structures. Case-based learning has been suggested as an effective approach to support th...

Engineering copper ferrite (CuFe2O4) nanosystems for medicine: a comprehensive review from design to biomedical applications

Abstract Biomedical micro/nanosystems are rapidly advancing toward integration of therapeutic and diagnostic nanoscale agents into unified platforms. Engineers still struggle to precisely control multiple functions in biocompatible designs. Copper ferrite (CuFe 2 O 4 ) nanopartic...

Effect of silymarin on hepatotoxicity in cancer patients undergoing chemotherapy: a systematic review and meta-analysis

Chemotherapy-induced hepatotoxicity frequently occurs in cancer patients and negatively impacts treatment adherence, dose management, and prognosis. Silymarin possesses general hepatoprotective properties. However, clinical evidence regarding its efficacy against chemotherapy-ind...

Patient delay and diagnosis-to-surgery interval in thyroid cancer and its related factors: a cross-sectional study from southern Iran

Thyroid cancer is affecting many people all around the world and is rising in incidence and prevalence. It is also highly treatable if diagnosed and addressed on time. This study aims to investigate the time intervals between symptom onset and seeking medical care, and also the t...

The serum interleukin 17 (IL-17) level and the prognosis of brain aneurysm- a case control study

Abstract Background Rupture of an Intracranial aneurysm (IA) may cause disability and death. Inflammation is a known mechanism in the pathogenesis of IAs, and several proinflammatory agents such as interleukins, tumor necrosis factors, complement, and so on are defined in the pat...

Incidence, pathogenesis, clinical manifestations, and pharmacological management of the 2026 Andes virus outbreak

Hantavirus is considered as a fatal zoonotic pathogen that can be commonly transmitted from rodents to humans. However, the Andes virus (ANDV), a type of New World hantavirus, can also be transmitted from human to human. It is the cause of the 2026 hantavirus outbreak on a cruise...

Adjunctive transcranial direct current stimulation in super-refractory status epilepticus: a prospective case series

Super-refractory status epilepticus (SRSE) is a life-threatening neurological emergency characterized by persistent seizures despite anesthetic therapy, with high associated mortality and limited treatment options. Transcranial direct current stimulation (tDCS) has emerged as a p...

Diagnostic yield and distribution of initial head CT findings in adult trauma patients: a retrospective cross-sectional study from a level I trauma center

Head trauma is a common presentation to the emergency department, and non-contrast head computed tomography (CT) is the choice modality for evaluating suspected traumatic brain injury (TBI). This study evaluated the diagnostic yield and distribution of initial CT findings and fac...

Development and evaluation of an Android-based platform for early MCI screening in an elderly population

Mild cognitive impairment (MCI) is an intermediate stage of cognitive decline fitting between normal cognition and dementia. With the growing aging population, this study aimed to develop and psychometrically validate an Android-based application for early MCI screening in elderl...

Emotion regulation and personality traits associated with resilience among Iranian emergency nurses: a cross-sectional study

Resilience is a critical psychological resource for emergency department (ED) nurses exposed to chronic occupational stress. While personality traits and cognitive emotion regulation strategies have both been linked to resilience, their relative contributions in high-acuity clini...