Shenzhen Second People's Hospital

Optimal liver segments for hepatic steatosis assessment using ultrasound attenuation imaging with MRI-PDFF as the reference standard

This study aims to identify optimal liver segments for hepatic steatosis assessment using UltraSound Attenuation (USAT) imaging, with MRI-proton density fat fraction (PDFF) as the reference standard. The prospective study included 240 patients who received weight loss counseling...

The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study

Abstract Objectives Observational studies on associations between various diseases and inflammatory bowel disease (IBD) are often limited by confounding and reverse causation. We aimed to assess potential causal relationships between a wide range of diseases and IBD, including Cr...

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

ABSTRACT Afterglow luminescence probes are limited by (i) a lack of new afterglow scaffolds; (ii) a dependence on initial external light activation, and (iii) aggregation‐caused quenching. Herein, we demonstrate for the first time that Ir(III) complexes of general formula Ir(C^N)...

Clinical outcomes and molecular features of CEBPA-mutated MPAL: a multi-center case series

Mixed phenotype acute leukemia (MPAL) is rare and aggressive, with no standard therapy. CEBPA mutations define favorable-risk AML, but their significance in MPAL is unknown. We reviewed eight CEBPA -mutated MPAL patients from five Chinese centers. Four received allo-HSCT in first...

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

ABSTRACT Afterglow luminescence probes are limited by (i) a lack of new afterglow scaffolds; (ii) a dependence on initial external light activation, and (iii) aggregation‐caused quenching. Herein, we demonstrate for the first time that Ir(III) complexes of general formula Ir(C^N)...

Degos Disease Presenting as a Hemorrhagic Brain Mass

The authors received no external funding. Artificial intelligence (AI; DeepSeek-V4-Pro, version v4-pro, released April 24, 2026, DeepSeek Inc.) was used only for language polishing of the manuscript text; no AI was used for image processing, diagnostic interpretation, or figure g...

Efficacy and Safety Assessment of Upadacitinib for SAPHO Syndrome: A Retrospective Study of 35 Patients

OBJECTIVE: This study aimed to evaluate the efficacy and safety of upadacitinib administered over a short-term period in patients with SAPHO syndrome. METHODS: In this 12-week retrospective observational study, eligible SAPHO syndrome patients diagnosed within the past year and t...

Functional characterization of a pore‐forming effector TseMt from the H4 type VI secretion system of Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through c...

Integrated proteomic and metabolomic analysis identifies complement activation and metabolic alterations in the serum of patients with idiopathic membranous nephropathy: an exploratory study

Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults, yet its pathogenesis remains incompletely understood. This exploratory study aimed to characterize serum molecular profiles in IMN patients by integrating proteomics and metabolomics analys...

Gender-specific non-linear relationship between BMI and estimated pulse wave velocity in Brazilian adults: a secondary analysis of cross-sectional data

Abstract Objective Arterial stiffness, commonly assessed through pulse wave velocity (PWV), is an important predictor of cardiovascular events. While body mass index (BMI) has been associated with arterial stiffness, the shape of this relationship and potential gender differences...

Construction and validation of a predictive model for postoperative pneumonia in elderly patients with hip fractures

To identify independent risk factors for postoperative pneumonia (POP) in elderly patients with hip fractures and to develop a nomogram for predicting its occurrence, we conducted a multicenter retrospective cohort study of elderly patients (≥ 60 years) who underwent hip fracture...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Assessment of masticatory muscle activity and mandibular border movement in skeletal class II malocclusion adolescents with mandibular retrognathia

<title>Abstract</title> Objective To investigate masticatory muscle activity and mandibular border movement in adolescents with skeletal class II malocclusion and mandibular retrognathia and explore the influence of mandibular retrognathia on masticatory system function. Methods...

Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes

Aims: To clarify the immunomodulatory mechanisms by which tibial cortex transverse transport (TTT) accelerates wound healing in a type 2 diabetic rat model, with particular focus on the dynamics of subsets of monocytes and macrophages. Methods: A total of 186 male Sprague-Dawley...

Isolated Myeloid Sarcoma of the Thoracic Spine as Initial Presentation of Acute Promyelocytic Leukemia: A Case Report and Literature Review

Introduction: Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia, typically presents with severe bleeding. However, the occurrence of APL with isolated myeloid sarcoma (MS) as the sole initial presentation is extremely rare, lacking typical clinical and labor...

Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study

Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population. We conducted a 6-month prospective cohort...

Measured resting energy expenditure via indirect calorimetry of critically ill patients: A comparison with predictive equations.

BACKGROUND AND OBJECTIVES: Assessing the resting energy expenditure (REE) of critically ill patients is essential for individual nutritional programs. We hypothesized that different evaluated ways for REE can be compared, and REE may be associated with disease severity and clinic...

Unraveling the hormonal causality in postpartum depression: findings from a two-sample Mendelian randomization study

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...