Shenzhen Second People's Hospital

Baseline anti-PLA2R antibody titer predicts treatment response and renal outcomes in rituximab-treated membranous nephropathy

Abstract Introduction As rituximab (RTX) has become a first-line therapy for idiopathic membranous nephropathy (IMN), identifying baseline predictors of treatment response is crucial for personalized management. This study was conducted to evaluate whether baseline anti-PLA2R tit...

ARID1B promotes DNA end resection via MDC1 and co-transactivation of DNA repair genes with c-MYC in small cell lung cancer

Abstract AT-rich interactive domain-containing protein 1B (ARID1B) has been implicated in DNA damage repair; however, its precise molecular mechanisms and contributions to small cell lung cancer (SCLC) pathogenesis remain incompletely defined. In this study, analysis of clinical...

Native plant effects on soil multifunctionality are mediated by microbial network reorganization in a subalpine spoil dump

Engineering activities have led to a worldwide increase in spoil dumps, posing severe challenges to ecological restoration, particularly in vulnerable ecological regions. Identifying suitable restoration strategies is critical for the rapidly re-establishment soil multifunctional...

Clinical features of cough syncope: a systematic review

Abstract Background Cough syncope (CS) is a rare subtype of syncope that remains underrepresented in evidence-based medicine. We aimed to characterize the clinical features of CS, with the aim of improving recognition and optimizing management strategies. Methods We present five...

Comparison of sevoflurane and propofol on the novel oxygenation index and respiratory mechanics in gynecological laparoscopic surgery: a randomized controlled trial

The novel oxygenation index (NOI), which incorporates mean airway pressure (Pmean) as a key respiratory parameter, is increasingly being investigated for its enhanced ability to reflect patients’ pulmonary function compared to the traditional oxygenation index (OI). This study ai...

PCSK9 inhibitors usage in South China: A Multi-Center Real-World Study

Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective for lipid management in high-risk patients with atherosclerotic cardiovascular disease. Their inclusion in China’s National Reimbursement Drug List and the Hong Kong Hospital Authority Drug Formulary...

Sitagliptin for Acute Graft-Versus-Host Disease Prevention in Alternative Donor Transplantation: A Randomized Phase III Trial

PURPOSE This trial evaluated whether the addition of sitagliptin to antithymocyte globulin (ATG)–based prophylaxis reduces the incidence of acute graft-versus-host disease (aGVHD) after alternative donor hematopoietic stem-cell transplantation. METHODS This prospective, multicent...

Parallel multilayer photoacoustic microscopy of slide-free histology using a droplet-shaped UV beam

Label-free and slide-free histological imaging of surgical tissues is vital for guiding surgical decisions during tumor resection. UV photoacoustic microscopy can be employed to discern atypical cytologic characteristics without using exogenous contrast agents, but the narrow dep...

Engineered exosome MDC@Ex-γ3-CeO₂@PDA for multi-target therapy of sepsis-induced acute lung injury

Sepsis-induced acute lung injury (ALI), with a complex pathogenesis, currently lacks clinically effective multi-target therapeutic strategies. Musca domestica cecropin (MDC), a promising antimicrobial, anti-inflammatory, and endothelial-repairing peptide, is limited by its high m...

Illness Experiences and Supportive Care Needs of Patients With Early‐Onset Colorectal Cancer: A Qualitative Systematic Review

AIMS: To synthesise the holistic illness experiences and supportive care needs of patients with early-onset colorectal cancer across the entire disease trajectory. BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed in indivi...

Cholecystoduodenal Fistula, Gallstone Ileus, and Choledocholithiasis: A Case Report and Literature Review

ABSTRACT Prompt diagnosis using CT is critical in gallstone ileus, as symptoms are often nonspecific. A combined surgical approach—comprising enterolithotomy, cholecystectomy, and fistula repair—effectively addresses both the obstruction and its underlying source, achieving favor...

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

ABSTRACT Peripherally restricted analgesics devoid of central side effects are urgently needed for postoperative pain management. The cannabinoid type‐1 receptor (CB 1 R) expressed on primary sensory neurons represents an attractive peripheral target, yet its specific role and me...

Toxicities of cancer immunotherapy: clinical manifestations, underlying mechanisms, and management

Abstract Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has transformed the treatment landscape of multiple malignancies. However, dysregulated immune activation can cause a wide range of toxicities tha...

Quantitative analysis of intersecting pentagon drawings for interpretable cognitive impairment screening

Background The intersecting pentagon drawing task in the Mini-Mental State Examination (MMSE), also referred to as the Pentagon Drawing Test (PDT), is a brief cognitive screening tool in Alzheimer's disease (AD) and other cognitive disorders. However, conventional manual scoring...

Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI ‐Derived VI ‐ RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study

ABSTRACT Background The associations of tumor location and reader experience with Vesical Imaging‐Reporting and Data System (VI‐RADS) performance remain unclear. Purpose To evaluate the associations of tumor location and reader experience with VI‐RADS performance in detecting mus...

Remnant cholesterol predicts adverse clinical outcomes in patients with hypertension: a post hoc analysis of the ALLHAT

Background and purpose: Remnant cholesterol (RC) has been proposed to play a role in regulating the residual cardiovascular risk in individuals with atherosclerotic cardiovascular disease (ASCVD), yet the underlying mechanisms remain elusive. This study aimed to investigate the r...

Endoscopic “Two-Step Method” for resection of a large tumor at the major duodenal papilla

Rationale: Endoscopic papillectomy is the standard treatment for noninvasive tumors of the ampulla of Vater. However, reports on the endoscopic resection of large tumors at the major duodenal papilla are rare. The “two-step” endoscopic approach described herein represents the fir...

Formula-dependent LDL-C threshold classification and reporting uncertainty in the UK Biobank

Abstract Objectives Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification near decision thresholds. We assessed formula-dependent LDL-C classification relative to direct LDL-C in UK Biobank...

Three-year Comparative Efficacy and Safety of Repeated Low-level Red-light Therapy and Orthokeratology for Myopia Control in Children

Repeated low-level red-light therapy (RLRL) has emerged as a noninvasive intervention for myopia control in children. This study compared the 3-year efficacy and safety of RLRL and orthokeratology (OK). This retrospective study included 86 children treated with RLRL ( n = 40) or...

Extracellular vesicles for next-gen therapeutics and drug delivery

Extracellular vesicles (EVs) are membrane-bound, nano-sized particles released by diverse cell types. They serve as key mediators of intercellular communication by transporting a broad repertoire of proteins, lipids, nucleic acids, and metabolites to recipient cells within a prot...