Shaqra University

Shared and Distinct T-Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T-Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

Abstract The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristic...

Arduino-controlled pulse electrodeposition for low-cost zinc coating on stainless steel

<title>Abstract</title> Metal corrosion is a major challenge in the manufacturing sector. Pulse electrodeposition (PED) is a promising effective technique for metal corrosion protection; however, the coating quality depends on the PED parameters. This study involved metal corrosi...

Variance-Adaptive Self-Regularizing Ensemble Learning for Robust Predictions in Small-Data Regimes

The small-data regime remains one of the most important and pressing problems in machine learning. With only a few hundred sample points in the training set, conventional ensemble methods are potentially unreliable because they have high variance, low generalization and are sensi...

Oxidative Stress-Associated Apoptotic Responses Induced by Lantana camara L. Flower–Derived Zinc Oxide Nanoparticles in Human Non-Small Cell Lung Cancer (NCI-H460) Cells

Lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the need for safer and more effective therapeutic strategies. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized via a green, biogenic approach using Lantana camara L. flower a...

Synthesis, modelling, biological activity of new thiophene hybridized with pyrazole, and/or pyridine analogues as potential DNA gyrase and topoisomerase IV inhibitors

Promoted by the well-established, valuable biological activity of thiophene-based hybrids, the study displayed the synthesis of two series of thiophene-pyrazole hybrids, 7a-c and thiophene-pyridine hybrids 9a-c, via reacting arylhydrazone with halogenated reagents and nucleophili...

Green synthesis of Ni-doped ZnO nanoparticles using Salvia hispanica and their antibacterial, anticancer and anti-virulence activities

An environmentally benign approach was employed to synthesize nickel-doped zinc oxide (Ni–ZnO) nanoparticles employing Salvia hispanica extract as a biologically derived reductant and capping material. Phytochemical profiling confirmed the abundance of phenolic and flavonoid comp...