Shanxi Provincial People’s Hospital

A cross-sectional analysis and forward projection of China’s gallbladder and biliary-tract cancer burden

Gallbladder and biliary tract cancer (GBTC) remains highly lethal. We examined 32-year epidemiological trends in China and projected outcomes to 2050. Using 2021 Global Burden of Disease (GBD) data, we extracted annual GBTC incident and prevalent cases, deaths, and disability-adj...

From Single-Modal Signal Recognition to Multidimensional Precision Detection: Breakthroughs and Innovations of Multi-Modal Sensors in Tumor Biomarker Detection

The sensitive detection of tumor markers is of great significance for clinical diagnosis. Due to the extremely low abundance of early tumor biomarkers and severe background interference from biological matrices, traditional single-modal atomolar biological testing generally has l...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial

Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s dise...

Effects of laparoscopic radiofrequency ablation combined with a levonorgestrel-releasing intrauterine system in patients with adenomyosis

To compare the 12-month clinical outcomes of laparoscopic RFA alone with those of laparoscopic RFA combined with LNG-IUS in patients with symptomatic adenomyosis. This single-center retrospective cohort study included 70 patients with adenomyosis who had complete 12-month follow-...

A protein-prioritised, colocalisation-informed genetic framework for safety hypothesis generation across inflammatory bowel disease therapeutic pathways

Human genetics can help prioritise target–outcome safety hypotheses before broad therapeutic exposure, but the strength and translational meaning of such signals depend on molecular proxy type, locus specificity and instrument architecture. We developed a protein-prioritised, col...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Development of a recurrence risk prediction model for intracranial atherosclerotic stroke using HR-VWI combined with radiomics

Based on high-resolution vessel wall imaging (HR-VWI) and radiomics, this study constructed a predictive model for stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis (sICAS), and evaluated the performance of the model. This study retrospectively...

Transparent ferroelectric 0.8Bi0.5Na0.5TiO3-0.2SrTiO3 resistors for neural synapse sensors and image recognition

Ferroelectric memristors possess advantages such as low operating voltage, high storage density and sub-micron-scale multi-state storage, making them widely used in fields such as information storage and mimicking biological synaptic functions. Here, the ferroelectric resistive s...

Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation

Background Chronic kidney disease (CKD) has a complex pathogenesis. Exposure to bisphenol A (BPA) is closely associated with its occurrence and development. Although it is known that BPA can affect the gut microbial community and that the gut-kidney axis serves a crucial role in...

Ganoderma Lucidum Polysaccharides Potentiate Low‐Dose Gemcitabine Against 4T1 Breast Tumors, Associated With Immune Activation and Gut Microbiota Remodeling

ABSTRACT Gemcitabine (GEM), a first‐line chemotherapeutic agent, may fail to prevent recurrence in some settings. Traditional Chinese medicine emphasizes Yin–Yang balance and “fuzheng” approaches and may offer complementary strategies. Ganoderma lucidum polysaccharides (GLP) exhi...

Diffuse uterine leiomyomatosis with a mesenteric smooth muscle lesion and a reported family history of uterine leiomyomas: a case report and literature review

Abstract Background Diffuse uterine leiomyomatosis (DUL) is a rare benign smooth muscle disorder characterized by diffuse proliferation of innumerable, poorly circumscribed leiomyomatous nodules throughout the myometrium. Because its clinical and radiologic features overlap with...

The application of nanoparticles green-formulated by Lycium barbarum leaf aqueous extract in the treatment of myocardial infarction

Cardiovascular diseases, including myocardial infarction, remain a main cause of mortality and morbidity worldwide, and raising attention has been directed toward plant-derived bioactive compounds and green nanotechnology for developing safer remedial approaches. This research de...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Smartphone Addiction Modulates Object-Based Attention

Smartphone addiction has been linked to altered attentional functioning. However, it remains unclear whether these alterations are associated with enhanced attentional bias or impaired attentional shifting. Moreover, previous studies have largely relied on self-report measures, a...

Stress hyperglycemia ratio as a risk factor for delirium in older intensive care unit patients: a retrospective cohort study

Delirium is a severe neurocognitive complication in older ICU patients, associated with poor outcomes. The stress hyperglycemia ratio (SHR), reflecting acute hyperglycemia relative to chronic glycemic control, may predict adverse outcomes. This study examined the association betw...

Decision fusion model for predicting WHO/ISUP grade of clear cell renal cell carcinoma based on multi-phase CT radiomics: a multicenter study

The pathological grading of clear cell renal cell carcinoma (ccRCC) plays a critical role in both its diagnosis and treatment. This study aimed to develop a decision fusion model based on multi-phase CT to predict the WHO/ISUP grade of ccRCC. This retrospective study included cli...

The revelation of immune cell interaction and the building of a prognostic model in diffuse large B-cell lymphoma under Hedgehog signaling abnormalities based on single-cell data

The Hedgehog (Hh) signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL) and helps facilitate tumor cell survival and proliferation. Currently, the role of the Hh signaling pathway in the prognosis of DLBCL has yet to be thoroughly investigated. RNA-Seq data and...