Shantou University

Construction and validation of a diagnostic model for interventricular septal hypertrophy based on electrocardiographic parameters and clinical factors

Interventricular septal hypertrophy (IVSH) is considered to be an early-stage alteration of left ventricular hypertrophy and is a major risk factor for a wide range of fatal arrhythmias and heart failure. We aimed to develop and validate a diagnostic model to detect patients with...

48-hour BPRI trajectories and 28-day mortality in vasoactive-supported hypertensive heart disease with heart failure

Hypertensive heart disease (HHD) complicated by heart failure is associated with high mortality in intensive care units. The Blood Pressure Response Index (BPRI), the ratio of mean arterial pressure to vasoactive-inotropic score, integrates hemodynamic targets and treatment inten...

Open public data and stock price delay: evidence from a quasi-natural experiment in China

Stock price delay serves as a key metric of information efficiency in stock markets, and identifying its determinants is essential for promoting market information efficiency. This study examines the effect of open public data (OPD) on stock price delay. Using the staggered adopt...

Unveiling the mechanism of metabolites derived from gut microbiota in the treatment of acute kidney injury via network pharmacology and bioinformatics

Abstract Background Acute kidney injury (AKI) affects a considerable proportion of patients that represents a major challenge for clinical treatment. Gut microbiota metabolites have been reported to attenuate acute kidney injury (AKI), yet their underlying mechanisms remain large...

Geometric nonlinear analysis of Timoshenko beams with variable cross-section using co-rotational formulation

Abstract. The geometrically nonlinear analysis of Timoshenko beams with variable cross-sections remains a challenging task in engineering practice, particularly for structures subjected to large deformations. While co-rotational (CR) formulations have been widely adopted for geom...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor demarcation are critical for effective treatment. Herein, we developed a strategic platform that combines a novel ultrasensitive magnetic...

EFAU-Net: efficient feature-enhanced U-Net for early pregnancy ultrasound segmentation

Early-pregnancy ultrasound images often contain gestational sac, yolk sac, and embryo regions with blurred boundaries, variable shapes, and small target sizes, which makes accurate segmentation difficult. In addition, many existing segmentation networks have high computational co...

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Local flow patterns determine the uneven distribution of atherosclerotic lesions, yet the underlying mechanism remains poorly defined. We previously reported that protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is implicated in atherosclerosis. Its role in flow-dependen...

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...

A Hierarchical Visual Navigation Algorithm for UAVs Integrating Artificial Potential Field and Deep Reinforcement Learning

To address the challenge of rapid and precise obstacle avoidance for unmanned aerial vehicles (UAVs) in complex urban environments, rugged canyons, and other unstructured environments, this paper proposes a vision-based navigation algorithm. By combining the strengths of deep rei...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype usi...

Toward In Situ ProgrammingLigand Desorption/AdsorptionDynamics of Metal Nanoparticles in Electrocatalysis

Abstract Ligand effects represent a long-last dilemma in metal nanocatalysis, as organic ligand coordination inevitably blocks active metal sites while maintaining structure stability of nanoparticles. To tackle this challenge, we demonstrate herein a supramolecular interaction-a...

Development and evaluation of a novel experimental autoimmune prostatitis model induced by a prostate-specific antigen mixture in rats

Objective To develop a novel experimental autoimmune prostatitis (EAP) model in rats using a prostate-specific antigen (PSA) mixture and to determine the optimal dose by evaluating the dose-dependent effects. Methods Male SD rats were divided into control (saline), low-dose (0.1...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Thromboxane A₂ analog U46619 promotes vascular smooth muscle cell apoptosis via Hippo pathway inhibition and its clinical relevance in aortic dissection

Apoptosis of human vascular smooth muscle cells (HAVSMCs) plays a pivotal role in the pathogenesis of aortic dissection (AD). In this study, we first observed in clinical samples that, compared with age- and sex-matched controls, patients with acute Stanford type A AD exhibited s...

Novel investigation on pine oil-diesel blends enriched with hydrogen and alumina nanoparticles used for diesel engines

This study investigates the performance, combustion, and emission characteristics of a diesel engine operating on a novel dual-fuel combination consisting of pine oil–diesel blends enriched with hydrogen and alumina (Al2O3) nanoparticles. A baseline blend of 80% pine oil and 20%...

Comparative efficacy and toxicity of two versus three induction chemotherapy cycles in locally advanced nasopharyngeal carcinoma: a propensity score matching analysis

Abstract Background For patients with locally advanced nasopharyngeal carcinoma (LA-NPC), the optimal number of cycles of induction chemotherapy (IC) remains uncertain. This study aimed to assess the efficiency and toxicity of different cycles of IC in LA-NPC patients. Methods Th...