Shanghai Zhangjiang Laboratory

HomocamptothecinPayloads with Enhanced Potency forAntibody-Drug Conjugates

Abstract Camptothecin derivatives, exemplified by DXd, are a dominant class of payloads for antibody-drug conjugates (ADCs). Herein, we describe the design and synthesis of H2, a novel homocamptothecin featuring a simplified hydroxybutyl structure that circumvents the complex ass...

Biocontrol of tomato soilborne diseases by fungivorous nematode Aphelenchoides bicaudatus

<title>Abstract</title> Crop soil-borne diseases caused by pathogens, such as Fusarium spp. and root-knot nematodes, contribute to substantial yield losses worldwide. This study investigated the biocontrol potential of the fungivorous nematode, Aphelenchoides bicaudatus isolate A...

Spinetoram‐based seed‐pelleting with synergistic mixtures enhances control of the diamondback moth

BACKGROUND: The diamondback moth, Plutella xylostella, is one of the most destructive pests of cruciferous crops worldwide. Its high fecundity, stress tolerance and seasonal migration often render traditional spray control ineffective. In this study, we propose an alternative met...

Chromosome-level genome assembly of landrace ‘Huangzhou’ provides insights into high cellulose accumulation in radish

<title>Abstract</title> Radish ( <italic>Raphanus sativus</italic> L.) is an important root vegetable crop with extensive morphological and nutritional diversity. The landrace radish, ‘Huangzhou’ (HZ) radish, origins in Huangzhou area, Hubei province of China, and characterized b...