Shanghai University

Cell-inspired dual-tandem catalytic nanoreactors drive targeted hearing protection

Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen specie...

Reducing Ion Transport Friction by Mitigated Diluent‐Solvent Interaction for Sodium–Sulfur Battery

ABSTRACT Sodium sulfur batteries have emerged as a promising candidate for large‐scale energy storage, while their practical implementation is severely hindered by sodium dendrite growth, unstable solid‐electrolyte interphase (SEI) films, and the polysulfide shuttle effect. Herei...

Artificial intelligence virtual bone organoids (AIVBOs)

Global population aging has made skeletal disorders a major threat to human health. Solid bone organoids reproduce skeletal physiology and pathology more faithfully than traditional models, yet remain limited in standardisation, real-time monitoring, and high-throughput use. Inte...

Degradation Behavior and Optimization Strategies for Metallic Materials in High-Temperature Hydrogen Service: A Review.

This review systematically examines the degradation behavior of metallic materials exposed to high-temperature hydrogen-rich environments, with particular focus on hydrogen metallurgy applications. The major degradation mechanisms, including hydrogen embrittlement, intergranular...

Observation of Magnetic‐Anisotropy Crossover and High‐Temperature Skyrmions in the Dirac Magnet Fe 3 Ge with a Distorted Kagome Lattice

ABSTRACT Topological materials that simultaneously host robust high‐temperature skyrmions and nontrivial electronic band structures have attracted tremendous interest owing to their distinctive advantages for both fundamental research and prospective technological applications. H...

Novel design and accelerated construction for long-span extradosed cable-stayed bridges

Over the past two decades, the construction of long-span extradosed cable-stayed bridges (CSBs) has experienced rapid growth, with numerous innovative designs and construction methods emerging in recent years. This study presents a comprehensive synthesis of innovative designs an...

Tertiary Amide Deep Eutectic Gel Electrolyte Eliminates Hydrogen Evolution and Enables Safe, Wide‐Temperature Lithium Metal Batteries

ABSTRACT Deep eutectic gel electrolytes (DEEs) based on amide‐Li + Lewis acid‐base coordination are promising for lithium metal batteries, yet they suffer from parasitic hydrogen evolution from reactive N‐H groups, poor interfacial stability, and inherent flammability. Here, we r...

Deep Cavitand Mediated Selective Aerobic Oxidative Cyclization of Thiols to Cyclic Disulfides

Abstract A mild supramolecular template strategy is reported for the selective synthesis of medium- to macrocyclic disulfides via aerobic oxidative cyclization of α,ω-dithiols in aqueous media. The water-soluble deep cavitand CV-1 serves as a multifunctional platform that synergi...

A Comprehensive Assessment Framework for the Sustainable Ecological Carrying Capacity of Chinese Cities Based on Time-Series Uncertainty and Interval-Valued Fermatean Fuzzy Sets

The assessment of sustainable ecological carrying capacity (SECC) serves as a crucial scientific foundation for supporting high-quality urbanization, advancing ecological civilization, and achieving the strategic goals of the “Dual Carbon” initiative. However, existing assessment...

Synergistic Optimization of Plasma-Sprayed Zirconia Coatings: Towards Ultra-High Hardness and Superior Wear Resistance

This study reported on the multi-objective optimization of atmospheric plasma spraying parameters for zirconia coatings by incorporating the response surface method with the desirability method, while simultaneously enhancing microhardness and reducing wear rates. The spraying va...

Fc N-glycosylation heterogeneity of anti-MDA5 IgG is associated with interstitial lung disease severity via regulating FcγR/C1q signaling in MDA5 + dermatomyositis: a cross‑sectional study

<title>Abstract</title> Background To characterize Fc N-glycosylation patterns of disease-specific IgG (DSIgG) in anti-MDA5-positive dermatomyositis (MDA5 + DM) and evaluate their associations with interstitial lung disease (ILD) severity. Methods Eighty-four patients with MDA5 +...

Reliability-Aware Multi-Modal Sentiment Analysis Under Missing and Corrupted Modalities

Multi-modal sentiment analysis integrates linguistic, acoustic, and visual evidence, yet the reliability of these streams varies across samples because of missing observations, masking, measurement noise, and feature corruption. This paper presents a trainable reliability-aware e...

MultidimensionalQuantitative Analysis of BiologicalResponses to DNA Nanoassemblies with Defined Structure and SurfaceChemistry

Abstract DNA nanoassemblies (DNs) have emerged as programmable platforms for biomedical applications; however, a quantitative understanding of how structure and surface chemistry jointly govern their biological behavior remains limited. Here, we establish a multidimensional analy...

Hierarchical Fuzzy Adaptive Control for Cooperative Pursuit‐Evasion Formation in Marine Surface Vehicles

ABSTRACT This paper investigates a formation‐based cooperative pursuit‐evasion (PE) problem for marine surface vehicles (MSVs) under local sensing and partially connected communication topologies. A distributed two‐layer control framework is proposed for the case where each pursu...

Symmetry-Guided Neural Approximation and Convolutional Non-Dominated Sorting on Synthetic Two-Objective Benchmarks Toward Option-Pricing Model Research in Financial Mathematics and Quantitative Economic Analysis

Two-objective optimization requires both reliable front approximation and explainable non-dominated extraction. This study develops a theoretical and computational method that maps sampled objective vectors to rasterized objective-space images and processes their Pareto structure...

Carbon Dots as ElectrostaticallyDriven Base-SelectiveChemical Compilers for Programmable Nucleic Acid Condensation

Abstract Cells execute complex biological functions through programmed biomolecular condensation, yet a general and programmable strategy for nucleic acid condensation in vitro remains challenging. Here, we demonstrate that carbon dots (CDs) function as an electrostatic-driven ve...

Behavioral Effects and Potential Mechanisms of Imidacloprid-and Flupyradifurone-Induced Neurotoxicity in Caenorhabditis elegans

Abstract Neonicotinoid insecticides raise concerns about neurotoxicity in nontarget organisms, motivating evaluation of alternatives such as flupyradifurone (FPF). We compared the neurotoxicity of imidacloprid (IMI) and FPF in Caenorhabditis elegans after 72 h exposure to 0.1–100...

Breathing ferroelectricity, flat-bands and multiple chiral phonons in van der Waals breathing kagome Nb3Cl8

Van der Waals layered Nb3X8 (X=Cl, Br, I) are predicted to integrate multiple intriguing physical properties, notably multiferroicity and flat-bands that are highly promising for novel-principle memories and superconductors. However, direct experimental validations such as the pr...

Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation

To characterize serum metabolic alterations across healthy controls, stable chronic obstructive pulmonary disease (SCOPD), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore candidate discriminatory metabolites for COPD-related comparisons. S...

Dual Drug-Loaded Enzyme-Responsive Liposomes Exert Specific Modulation on Liver Cancer Cells and Tumor-Associated Macrophages In Vitro

Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy and remains a major contributor to global cancer mortality. In situ vaccination (ISV) holds great potential for HCC therapy. Still, its efficacy is severely limited by intrinsic antigen scarcity and the tumo...