Shanghai Tenth People's Hospital

“Precision planning for tissue expansion: A three-dimensional scanning-based predictive model to guide surgical timing”

Tissue expansion remains an essential reconstructive technique, yet the timing of expander removal is still largely determined by subjective clinical judgment. We developed a three-dimensional (3D) scanning-based quantitative workflow to objectively monitor expansion progress and...

CD147+ Cancer‐Associated Fibroblasts Promote PD‐L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL‐6 Signaling

BACKGROUND: Targeting CD147 on hepatocellular carcinoma (HCC) cells has demonstrated therapeutic efficacy. Cancer-associated fibroblasts (CAFs) have been identified as critical components of the tumor microenvironment. The role of CD147 in CAFs is still unclear, and this study ai...

UBE2K-FBXO11 complex activates Wnt signaling by stabilizing β-catenin through lysine 63-linked polyubiquitination

Abstract Β-catenin is regulated by phosphorylation and lysine (K)48-linked ubiquitination, which target it for proteasomal degradation. While the degradation machinery of β-catenin, including the destruction complex, has been extensively studied, regulators that stabilize β-caten...

From accuracy to applicability: A consensus-aligned narrative review on bedside ECG- and ultrasound-based PICC tip positioning

Peripherally inserted central catheter (PICC) tip positioning is a technically mature field characterized by heterogeneous evidence. International consensus guidelines consistently recommend bedside intracavitary electrocardiography (IC-ECG) and ultrasound-based strategies as fir...

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) currently lacks effective targeted therapeutics, while interleukin‐22 (IL‐22) as a potential treatment approach faces challenges in the clinical translation due to off‐target risks associated with systemic delivery....

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage. In this study, we developed pH‐responsive ZIF‐90 nanoparticles loaded with puerarin (PU) (ZIF‐90@PU) for microenvironment‐responsive osteoporosi...

Remnant cholesterol predicts adverse clinical outcomes in patients with hypertension: a post hoc analysis of the ALLHAT

Background and purpose: Remnant cholesterol (RC) has been proposed to play a role in regulating the residual cardiovascular risk in individuals with atherosclerotic cardiovascular disease (ASCVD), yet the underlying mechanisms remain elusive. This study aimed to investigate the r...

Formula-dependent LDL-C threshold classification and reporting uncertainty in the UK Biobank

Abstract Objectives Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification near decision thresholds. We assessed formula-dependent LDL-C classification relative to direct LDL-C in UK Biobank...

Identification of annexin A10 as a candidate serum biomarker associated with neurological outcome after cardiac arrest

Accurate early neurological prognostication following cardiac arrest remains a major clinical challenge because of post-resuscitation brain injury. Although biomarkers such as neuron-specific enolase (NSE) and neurofilament light chain (NfL) are widely investigated, limitations i...

Integrated machine learning and clinical validation identify COL21A1 as a potential biomarker for sarcopenia

Sarcopenia is a progressive skeletal muscle disorder characterized by loss of mass, strength, and function. However, reliable molecular biomarkers for early detection remain limited. This study aimed to identify and validate potential biomarkers for sarcopenia through a combinati...

Estradiol-to-testosterone ratio versus testosterone in relation to thromboelastographic clot strength in men with type 2 diabetes: a secondary cross-sectional analysis

Testosterone deficiency is common in men with type 2 diabetes mellitus (T2DM) and has been associated with a procoagulant thromboelastography (TEG) profile. Whether the estradiol-to-testosterone ratio (E2/T) provides information beyond testosterone alone is uncertain. We performe...

Simultaneous broad-spectrum antibacterial and regenerative therapy for diabetic wounds using sonosensitive peptide composite hydrogel

Diabetic wound infections remain highly refractory to treatment due to persistent bacterial colonization, oxidative stress, dysregulated inflammation, vascular insufficiency, and impaired extracellular-matrix remodeling. Current therapeutic strategies remain limited by poor tissu...

Morphology‐Engineered Bismuth‐Porphyrin MOFs for H 2 S Scavenging Mediated Synergistic Photo‐Immunotherapy Against MRSA‐Infected Diabetic Wounds

ABSTRACT Diabetic wounds infected with methicillin‐resistant Staphylococcus aureus (MRSA) pose a significant challenge to clinical healing. Proliferating MRSA not only invades neutrophils to induce immunosuppression but also produces hydrogen sulfide (H 2 S) and forms biofilms to...

Estimated glucose disposal rate and incident cardiovascular disease across ageing cohorts in China, England, and the United States: cross-national consistency and transportability

The estimated glucose disposal rate (eGDR), an insulin-resistance surrogate derived from routine clinical variables, has been associated with cardiovascular disease (CVD). We examined its association with incident CVD, cross-national transportability, and incremental discriminati...

Neonatal Reversible Aortic Constriction Mice Model Unlocks Distinctive Footprints of Young Heart Recovery

BACKGROUND: Left ventricular (LV) reverse remodeling has been linked to long-term prognosis and life quality of pediatric patients with LV outflow tract obstruction. However, a lack of suitable animal model limits further study of LV reverse remodeling in young hearts. This study...

L-arginine alleviates polycystic ovary syndrome restore ovulation and androgen levels by regulating gut microbiota

Abstract Emerging research highlights the crucial role of gut microbiota and its metabolites in managing metabolic disorders, implicating their contribution to the pathophysiology of polycystic ovary syndrome (PCOS). The present study employed a multi-omics research approach enco...

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

ABSTRACT Bone metastases (BoMs) are a major clinical challenge across cancer types, yet mechanistic insights remain limited by small cohorts and insufficient profiling depth. Here, we present a single‐cell RNA sequencing atlas of 95 BoMs, 22 healthy bone marrows (hBMs) and 129 pr...

Structural characteristics of the temporomandibular joint in temporomandibular joint disorder syndrome: a preliminary cross-sectional study based on MRI

Temporomandibular joint disorder syndrome (TMD) is a prevalent oral-maxillofacial condition. The Diagnostic Criteria serve as a widely used diagnostic framework for TMD with high specificity, yet its sensitivity requires further optimization. In contrast, magnetic resonance imagi...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...

Epigenetic repression of IL-1β by C1QBP restricts Dectin-1-mediated host defense against murine invasive candidiasis

Invasive candidiasis, predominantly caused by Candida albicans, threatens immunocompromised individuals with high mortality. Dendritic cell-derived interleukin-1β, orchestrated via Dectin-1-mediated β-glucan recognition, is central to antifungal defense. While the Dectin-1/Syk/CA...