Institution
Shanghai Ninth People's Hospital
Recent research
- Health & MedicineOpen access
Home enteral nutrition management in postoperative oral cancer patients: an evidence summary
Abstract Background This study aimed to establish a standardized management system for home enteral nutrition (HEN) for patients with postoperative oral cancer and provide scientific guidance for clinical professionals by systematically searching relevant literature and summarizi...
- BiologyOpen access
Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...
- BiologyOpen access
ABSTRACT Periodontitis is a chronic inflammatory disease characterized by persistent inflammation and limited repair at sites of alveolar bone loss. Although excessive reactive oxygen species (ROS) are recognized drivers of periodontal tissue damage, oxidative stress alone does n...
- Biology
AIM: To investigate the mechanism of the autotaxin/lysophosphatidic acid (ATX/LPA) axis in regulating osteoclastogenesis and inflammation in periodontitis. MATERIALS AND METHODS: The expression levels and clinical relevance of the ATX/LPA axis were studied by collecting clinical...
- BiologyOpen access
Custom prosthetic rehabilitation of ocular defects with a digital workflow
Abstract Purpose To use digital technologies, including high-resolution imaging, computer-aided design (CAD), and three-dimensional (3D) printing, to introduce a streamlined process by enabling rapid, reproducible, and cost-effective digital fabrication of orbital prostheses, the...
- Health & MedicineOpen access
Synthetic β-amino acid polymer promoting keratocyte adhesion and corneal regeneration
Corneal damage ranks among the leading causes of visual impairment globally. Given the prevalence of corneal diseases and challenges of donor cornea shortages and immune rejection, there is an urgent need to develop alternative materials for corneal repair. Although decellular co...
- Health & MedicineOpen access
Abstract Background BRAF-mutant (BRAF-MT) colorectal cancer (CRC) represents a clinically aggressive subtype characterized by distinct biological features and significantly worse prognosis compared to BRAF wild-type (BRAF-WT) CRC, with median survival reduced by approximately 40%...
- Health & MedicineOpen access
Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...
- Health & MedicineOpen access
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
ABSTRACT Diabetic foot ulcers are a major complication of diabetes characterized by persistent inflammation and impaired tissue repair, in part driven by aberrant activation of the cGAS‐STING innate immune pathway. Precision immunomodulation in the protease‐rich wound microenviro...
- Health & MedicineOpen access
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with a complex and multifaceted etiology. Although metabolic disturbances have been linked to osteoarthritis in other joints, their role in TMJOA remains unclear. This study aimed to investigate the associat...
- Health & MedicineOpen access
NDUFV1 activation mediates high glucose-induced apoptosis in peritoneal mesothelial cells
Peritoneal mesothelial cells (PMCs) are critical components of the peritoneum, and prolonged exposure to high glucose in peritoneal dialysis fluid can lead to structural and functional impairment of the peritoneal membrane. However, whether such cellular damage is caused by gluco...