Shanghai Mental Health Center

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To pro...

A generalizable biopsychosocial risk score for stratifying disease vulnerability in healthy populations

Prospective risk stratification of future adverse health outcomes before clinical onset among ostensibly healthy individuals is an important goal of preventive and precision medicine, yet current tools remain largely disease-specific and do not provide an integrated measure of he...

Deep fusion for multimodal subtype classification of major depressive disorders based on TSCANet

Major Depressive Disorder (MDD) represents a major global health burden, characterized by high recurrence rates and an increased risk of suicide. Traditional clinical diagnoses rely primarily on subjective scales, which limits their objectivity in accurately distinguishing MDD su...

Study on the impact of meditation intervention on the white matter structure in schizophrenia

Schizophrenia is associated with abnormal white matter structural connectivity, and meditation has been investigated as an adjunctive intervention for clinical symptoms. This study examined whether an 8-month meditation intervention was associated with longitudinal changes in cli...

Heterogeneities by Age and Sex in Associations Between Electronic Device Use Frequency and Comorbid Mental Health Symptoms: The Roles of Self-Efficacy and Social Support

Objectives: This study aims to examine age and sex disparities in the relationships between the weekly frequency of electronic device use and mental health comorbidities (anxiety symptoms, depressive symptoms, and stress), and the roles of self-efficacy and social support. Method...

Effects of robot-assisted gait training on walking capacity and gross motor function in children with central nervous system impairments: a systematic review and meta-analysis predominantly based on cerebral palsy studies

Abstract Background Children with cerebral palsy (CP) and other central nervous system (CNS) impairments often have limitations in walking capacity and gross motor function. Robot-assisted gait training (RAGT) is increasingly used in pediatric rehabilitation, but existing evidenc...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

The relationship between biological rhythm disturbances and mixed features in major depressive episodes: a multicenter cross-sectional study

Major depressive episodes (MDEs) with mixed features are associated with greater clinical complexity and may represent an important indicator of bipolarity. Biological rhythm disturbances have been implicated in mood disorders, but their relationship with mixed features during MD...

Occupational creativity and liability to psychiatric disorders: a bidirectional Mendelian randomization study

The long-standing “mad genius” hypothesis proposes a link between creativity and psychiatric illness, but existing genetic evidence has largely relied on genetic correlations and polygenic associations rather than approaches designed to evaluate directional effects. We conducted...

IL-1α and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder

<title>Abstract</title> <bold>Background:</bold> It’s common comorbidity for Major Depressive Disorder (MDD), anxiety, and pain, underpinned by shared chronic inflammatory processes, this study aimed to identify etiological inflammatory biomarkers, focusing on MDD individuals wit...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

Distinctive subcortical connectivity predicts treatment response in first-episode schizophrenia

Background Subcortical regions are widely implicated in the pathological mechanisms and treatment of schizophrenia, and accumulating evidence, including our prior findings, suggests that subcortical functional dysconnectivity is closely associated with treatment response. Accordi...