Shanghai Medical College of Fudan University

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...

Genetic origin and forensic analysis of han populations from four districts in Shanghai, China, based on Y-chromosome STR and SNP markers

Y-short tandem repeats (STRs) and Y-single nucleotide polymorphisms (SNPs) on the Y chromosome are genetic markers unique to men. They are widely used in identification, forensic medicine and paternal lineage tracing. Because of their strict paternal genetic characteristics, they...

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...

The fluoride channel genes crcB1 and crcB2 contribute to high-level fluoride resistance and virulence in Staphylococcus aureus

Staphylococcus aureus ( S. aureus ) can colonize the oral cavity and cause infections ranging from localized disease to systemic illness. Fluoride is widely used in oral care for caries prevention and can inhibit many oral microorganisms. However, S. aureus exhibits high-level fl...

Development and validation of a multiplex targeted PCR-sequencing assay for opioid pharmacogenes genotyping

Interindividual variability in opioid analgesic efficacy and susceptibility to adverse effects is substantially influenced by genetic polymorphisms in pharmacokinetic and pharmacodynamic pathways. However, simultaneous detection of multiple predefined opioid-related variants with...

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Abstract Despite improved survival rates with dual trastuzumab and pertuzumab therapy, patients with HER2-positive breast cancer frequently experience disease progression due to intrinsic or acquired resistance. Elucidating the underlying mechanisms of resistance and identifying...

Exploratory integration of spatial transcriptomics and MRI phenotypes to characterize metastasis-associated microenvironmental features in ipsilateral breast tumor recurrence

Ipsilateral breast tumor recurrence (IBTR) presents a critical clinical challenge, as it is strongly associated with a high risk of subsequent distant metastasis, the primary cause of mortality. Although the spatial organization of the tumor microenvironment (TME) may contribute...

A Manganese-Chlorella Hydrogel for an Integrated “Remove–Remodel–Repair” Strategy in Pancreatic Cancer Therapy

Abstract Pancreatic cancer faces the challenges of tumor progression and postoperative pancreatic fistula during the perioperative period, which severely affect patient prognosis. In this study, an injectable self-healing multifunctional hydrogel (CMCGel) was developed based on d...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Genomic and transcriptomic landscape of overweight Chinese breast cancer reveals NOTCH2 mutation–mediated endocrine resistance and therapeutic strategies

Abstract Background Obesity (OB) and overweight (OW) are common in patients with breast cancer and are associated with inferior outcomes, yet their impact on tumor molecular architecture remains incompletely understood. This study aimed to define the genomic and transcriptomic fe...

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...

Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer

Abstract Background: Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Methods: Data from pa...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

ABSTRACT Triple‐negative breast cancer (TNBC) derives limited benefit from immune checkpoint blockade, largely owing to primary resistance shaped by the tumor immune microenvironment. Here, baseline transcriptomic profiling of a neoadjuvant chemoimmunotherapy cohort identified ca...

P1.245. Real-Time AI-Based Thoracic Duct Recognition During Thoracoscopic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Thoracic duct injury during thoracoscopic esophagectomy may result in postoperative chylothorax, a serious complication associated with increased morbidity. However, intraoperative id...

Social determinants of health substantially enhance identification of high-risk CKM syndrome progression: a longitudinal prediction study based on data from CHARLS

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomo...

Long-term outcomes of hemithyroidectomy in unexpected hereditary medullary thyroid cancer: a nationwide observational study

Total thyroidectomy (TT) is the standard surgical approach for hereditary medullary thyroid cancer (hMTC). However, it is not rare in clinical practice for patients with hMTC to initially undergo hemithyroidectomy (HT) because the hereditary nature of the disease is not recognize...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Biomarker-Stratified Phase II Trial of Trastuzumab Rezetecan in Advanced Salivary Gland Carcinoma Across Cohorts With High and Low Human Epidermal Growth Factor Receptor 2 Expression

PURPOSE Systemic treatment options for advanced salivary gland carcinoma (SGC) are limited, and prospective data for human epidermal growth factor receptor 2 (HER2)–directed therapy remain sparse, particularly in HER2-low disease. We evaluated trastuzumab rezetecan (SHR-A1811), a...