Shanghai Medical College of Fudan University

Social determinants of health substantially enhance identification of high-risk CKM syndrome progression: a longitudinal prediction study based on data from CHARLS

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...

P1.245. Real-Time AI-Based Thoracic Duct Recognition During Thoracoscopic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Thoracic duct injury during thoracoscopic esophagectomy may result in postoperative chylothorax, a serious complication associated with increased morbidity. However, intraoperative id...

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomo...

Long-term outcomes of hemithyroidectomy in unexpected hereditary medullary thyroid cancer: a nationwide observational study

Total thyroidectomy (TT) is the standard surgical approach for hereditary medullary thyroid cancer (hMTC). However, it is not rare in clinical practice for patients with hMTC to initially undergo hemithyroidectomy (HT) because the hereditary nature of the disease is not recognize...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Biomarker-Stratified Phase II Trial of Trastuzumab Rezetecan in Advanced Salivary Gland Carcinoma Across Cohorts With High and Low Human Epidermal Growth Factor Receptor 2 Expression

PURPOSE Systemic treatment options for advanced salivary gland carcinoma (SGC) are limited, and prospective data for human epidermal growth factor receptor 2 (HER2)–directed therapy remain sparse, particularly in HER2-low disease. We evaluated trastuzumab rezetecan (SHR-A1811), a...

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Background: Humoral immunity targeting hepatitis B virus (HBV) surface antigen (HBsAg) is critical for viral clearance. However, the phenotypic, repertoire, and metabolic features of HBsAg-specific B cells in chronic hepatitis B (CHB) remain incompletely defined. Methods: HBsAg-s...

Clinicopathologic and prognostic value of HER2 alterations in non-small cell lung cancer

Abstract Background Human epidermal growth factor receptor 2 ( HER2 ) alterations represent emerging therapeutic targets in non-small cell lung cancer (NSCLC). However, the clinicopathological and prognostic values of HER2 mutations, amplification, and over expression remain poor...

Training experience, perceived needs, and preferences for epidemiological investigation and risk assessment training among infection prevention and control practitioners in Shanghai

Infection prevention and control practitioners (IPCPs) play a crucial role in managing infectious diseases within hospitals. In this study, we aim to assess the training experience, perceived training needs, and training preferences of IPCPs in Shanghai regarding epidemiological...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Cancer of unknown primary: the evolution of tissue of origin identification in the artificial intelligence era

Cancer of Unknown Primary (CUP) presents substantial diagnostic and therapeutic challenges owing to its heterogeneous nature and the absence of an identifiable primary tumor site. This review provides a structured search of the pathogenesis, epidemiological characteristics, and l...

Comparative analysis of the CT and MRI features of pancreatic colloid carcinoma

To investigate the CT and MRI features of pancreatic colloid carcinoma (PCC) and to correlate imaging findings with histopathological characteristics. The CT and MRI images and clinical data of 15 patients with PCC confirmed by surgical resection and histopathological examination...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

MRgFUS-enabled nanogel platform for synergstic chemo-immunotherapy in glioblastoma

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis and limited responsiveness to temozolomide (TMZ)-based chemoradiotherapy. Treatment remains hindered by the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), acquired TMZ resistance, a...