Shanghai Medical College of Fudan University

Frequency-specific oscillations track parallel processing of linguistic structural and lexical-semantic information from perception to decision

The ability to perceive linguistic features is essential for language comprehension, yet how our brains dynamically recognize, integrate and process distinct linguistic features is still controversial. Here, we employ magnetoencephalography to examine the spatiotemporal organizat...

Virological Events During Immune Checkpoint Inhibitor Therapy: A Multi-Source Evaluation

Background/Objectives: Virological findings during immune checkpoint inhibitor (ICI) therapy may represent viral loss of control, pre-existing infection, tumour biomarkers, or infection after immune-related adverse event (irAE)-directed immunosuppression. Distinguishing these pos...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Identification of Immune-Related Hub Genes as Candidate Biomarkers for Preeclampsia: Integrative Transcriptomic and Machine Learning Approaches

Abstract Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and is increasingly recognized as a disorder involving immune dysregulation. However, reliable candidate biomarkers and key molecular alterations associated with PE remain unclear. We integrated multi...

A generalizable biopsychosocial risk score for stratifying disease vulnerability in healthy populations

Prospective risk stratification of future adverse health outcomes before clinical onset among ostensibly healthy individuals is an important goal of preventive and precision medicine, yet current tools remain largely disease-specific and do not provide an integrated measure of he...

Real-world clinical outcomes of trastuzumab deruxtecan in patients with HER2-low metastatic breast cancer

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) approved for HER2-low metastatic breast cancer (mBC), showing improved survival outcomes in clinical trials. However, real-world evidence on its effectiveness among Chinese patients remains limited. Patients with...

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

Combined Accommodation and Fusional Training Paradigm Versus Prism Correction for Small-Angle Acute Acquired Comitant Esotropia: A Cohort Study

This study explored 6-month ocular alignment and visual function outcomes associated with a combined accommodative and fusional training paradigm and compared them with outcomes observed after prism correction in patients with small-angle acute acquired comitant esotropia. This p...

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

BACKGROUND: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significant obstacle in clinical practice. METHODS: studies were car...

The clinicopathological significance and mechanisms of interstitial foam cells formation in patients with primary membranous nephropathy

Accumulation of foam cells (FCs) in interstitium is frequently observed in membranous nephropathy (MN). However, the pathophysiological significance of those cells remains poorly understood. It is generally accepted that interstitial FCs are derived from macrophages with lipid de...

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

ABSTRACT Acquired resistance to temozolomide (TMZ) remains a major therapeutic challenge in glioblastoma (GBM), with metabolic reprogramming emerging as a critical driver of treatment failure. Procollagen lysyl hydroxylase 1 (PLOD1) is identified as a key regulator of adaptive me...

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...

Coronary CT Angiography‐Derived Plaque and Hemodynamic Characteristics for In‐Stent Restenosis: A Self‐Controlled Study

ABSTRACT Background In‐stent restenosis (ISR) after percutaneous coronary interventions (PCI) remains a significant challenge. Aims This study aimed to investigate the predictive ability of coronary CT angiography (CTA) derived plaque and hemodynamic characteristics for ISR. Meth...

Large language model–assisted preoperative communication reduces patient anxiety and physician workload in prostate cancer: a prospective randomized phase II trial

Abstract This prospective, randomized, single-blinded, phase II trial evaluated whether large language model (LLM)-assisted preoperative communication, compared with standard communication, reduces patient anxiety and improves illness perception and satisfaction while decreasing...

NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity

Recently, 5-methylcytosine (m5C) modification has been identified in HIV-1 genomic RNA. However, the functional role of this RNA modification in the antiviral innate immune response remains unclear. Here, we demonstrate that m5C modification of HIV-1 genomic RNA enables the virus...

Myf5 Progenitors Define the Lineage Identity of Somitic Vascular Smooth Muscle Cells

Vascular smooth muscle cell (VSMC) heterogeneity drives region-specific aortic pathologies, yet the roles of somite-derived lineages remain unclear. Utilizing Myf5 and MyoD lineage tracing alongside a smooth muscle-specific Myf5 conditional knockout model, we show that Myf5-deriv...

Distinct Molecular Landscape and Clinical Subtype of HPV-Positive Esophageal Squamous Cell Carcinoma

Background: This study aimed to investigate the prevalence of human papillomavirus (HPV) infection in Chinese patients with esophageal squamous cell carcinoma (ESCC) and its association with driver gene mutations (EGFR, KRAS, PIK3CA, PTEN), clinicopathological features, and progn...

Eggerthella lenta disrupts the gut vascular barrier to drive colorectal cancer liver metastasis

Distant metastasis is the leading cause of death in colorectal cancer (CRC), and the gut vascular barrier (GVB) is the first obstacle to hematogenous spread. To investigate whether GVB function is directly influenced by metastasis-associated bacteria, we analyzed two cohorts comp...

Preoperative prediction of MSI status in gastric cancer based on CT and radiomics: a multicenter study

To develop a non-invasive prediction model and assess its predictive power of microsatellite instability (MSI) status in gastric cancer (GC). This retrospective study included 1,012 GC patients from three hospitals during January 2019 and January 2023. Patients from hospital C we...

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...